A5100758537- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis B Virus Studies
- Bone fractures and treatments
- Traumatic Brain Injury Research
- Acute Ischemic Stroke Management
- Asthma and respiratory diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cancer, Stress, Anesthesia, and Immune Response
- Liver Disease Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Cancer Treatment and Pharmacology
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
Capital Medical University
2015-2025
Capital University
2013-2025
Soochow University
2020-2025
Regeneron (United States)
2024-2025
Yunnan University
2024
Fujian Medical University
2021-2024
Beijing Chao-Yang Hospital
2015-2024
Beijing Obstetrics and Gynecology Hospital
2020-2024
Shanghai Sixth People's Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
Under the framework of graph-based learning, key to robust subspace clustering and learning is obtain a good similarity graph that eliminates effects errors retains only connections between data points from same (i.e., intrasubspace points). Recent works achieve performance by modeling into their objective functions remove inputs. However, these approaches face limitations structure should be known prior complex convex problem must solved. In this paper, we present novel method eliminate...
Abstract Nitrocellulose (NC) membranes, as porous paper-like substrates with high protein-binding capabilities, are very popular in the field of point-of-care immunoassays. However, generating robust hydrophobic structures NC membranes to fabricate microfluidic paper-based analytical devices (μPADs) remains a great challenge. At present, main method relies on an expensive wax printer. In addition, easy adhere during printing process due electrostatic adsorption. Herein, we developed facile,...
Abstract Background Epithelial-mesenchymal transition (EMT) plays a crucial role in small airway fibrosis of patients with chronic obstructive pulmonary disease (COPD). Increasing evidence suggests that the urokinase plasminogen activator receptor (uPAR) is involved pathogenesis COPD. Increased uPAR expression has been implicated promotion EMT numerous cancers; however epithelial cells COPD remains unclear. In this study, we investigated degree and lung epithelium patients, verified effect...
Network pharmacology-based identification of key pharmacological pathways Yin–Huang–Qing–Fei capsule acting on chronic bronchitis Guohua Yu,1,2,* Yanqiong Zhang,2,* Weiqiong Ren,3 Ling Dong,1 Junfang Li,2,4 Ya Geng,2,5 Yi Zhang,2 Defeng Li,2 Haiyu Xu,2 Hongjun Yang2 1School Chinese Materia Medica, Beijing University Medicine, 2Institute China Academy Medical Sciences, Beijing, 3The First Affiliated Hospital Hunan Traditional Changsha, 4School Tianjin Tianjin, 5School Basic Shandong Jinan,...
Targeting the capsid protein of hepatitis B virus (HBV) and thus interrupting normal formation have been an attractive approach to block replication HBV viruses. We carried out multidimensional structural optimizations based on heteroaryldihydropyrimidine (HAP) analogue Bay41-4109 (1) identified a novel series inhibitors that demonstrated promising cellular selectivity indexes, metabolic stabilities, in vitro safety profiles. Herein we disclose design, synthesis, structure-activity...
Abstract Background Treatment options for Chinese patients with locally advanced or metastatic squamous‐cell non‐small‐cell lung cancer (sqNSCLC) after failure of first‐line chemotherapy are limited. This study (ORIENT‐3) aimed to evaluate the efficacy and safety sintilimab versus docetaxel as second‐line treatment in sqNSCLC. Methods ORIENT‐3 was an open‐label, multicenter, randomized controlled phase 3 trial that recruited stage IIIB/IIIC/IV sqNSCLC platinum‐based chemotherapy. Patients...
In this paper, we recast the subspace clustering as a verification problem. Our idea comes from an assumption that distribution between given sample x and cluster centers Omega is invariant to different distance metrics on manifold, where each defined probability map (i.e. soft-assignment) Omega. To verify so-called invariance of distribution, propose deep learning based method which simultaneously learns compact representation using neural network assignment by minimizing discrepancy...
Described herein are the discovery and structure–activity relationship (SAR) studies of third-generation 4-H heteroaryldihydropyrimidines (4-H HAPs) featuring introduction a C6 carboxyl group as novel HBV capsid inhibitors. This new series HAPs showed improved anti-HBV activity better drug-like properties compared to first- second-generation HAPs. X-ray crystallographic study analogue 12 (HAP_R01) with Cp149 Y132A mutant hexamer clearly elucidated role played for increased binding affinity,...
Nanomedicines have significant advantages in enhancing the oral bioavailability of drugs, but a deeper understanding underlying mechanisms remains to be interpreted. Hence, present study aims explain uptake and trafficking mechanism for 6-MP nanomedicines we previously constructed.6-MP loaded poly(lactide-co-glycolide) (PLGA) (6-MPNs) were prepared by multiple emulsion method. The transcytosis 6-MPNs was investigated Caco-2 cells, monolayers, follicle associated epithelium (FAE) monolayers...
Background: UK pediatric asthma prevalence is among the highest in Europe, and although clinical economic burden of adults well described, childhood data lacking. We assessed children to better understand impact asthma. Methods: This was a retrospective, case-matched, longitudinal analysis using Clinical Practice Research Datalink GOLD database linked patient-level (Hospital Episode Statistics Office for National datasets) selected patient (aged 6– 11 years) records 2017. Severe exacerbation...
To estimate the current prevalence rate of urinary incontinence (UI) and to identify risk factors in Chinese women, we conducted a population-based survey 3058 women Beijing, China, 2009. The UI was estimated be 22.1%, with stress (12.9%) being more prevalent than urgency (1.7%) mixed (7.5%). rates UI, increased age, highest recorded participants aged ≥70 years. However, most commonly seen 50 69 Risk for included aging, lower education background, older age menarche, menstrual disorder,...