A5100733932- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Mesoporous Materials and Catalysis
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- IL-33, ST2, and ILC Pathways
- Polyoxometalates: Synthesis and Applications
- Extracellular vesicles in disease
- RNA modifications and cancer
- Zeolite Catalysis and Synthesis
- Diverticular Disease and Complications
- RNA Interference and Gene Delivery
- Catalytic Processes in Materials Science
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Mycobacterium research and diagnosis
- Cancer-related gene regulation
East China University of Science and Technology
2025
ShenZhen People’s Hospital
2019-2025
Jinan University
2018-2025
Southern University of Science and Technology
2020-2025
Army Medical University
2019-2024
Xinqiao Hospital
2019-2024
Shenzhen Second People's Hospital
2019-2024
Harbin Institute of Technology
2012-2021
Second Hospital of Shandong University
2021
University of South China
2018
Plant-derived exosome-like nanoparticles (PDENs) have been paid great attention in the treatment of ulcerative colitis (UC). As a proof concept, we isolated and identified Portulaca oleracea L-derived (PELNs) from edible L, which exhibited desirable nano-size (~ 160 nm) negative zeta potential value (-31.4 mV). Oral administration PELNs effectively suppressed expressions pro-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-1β) myeloperoxidase (MPO), increased levels anti-inflammatory cytokine...
Probiotics have been proposed as a potential strategy for managing ulcerative colitis (UC). However, the underlying mechanisms mediating microbiota-host crosstalk remain largely elusive. Here, we report that Limosilactobacillus reuteri (L. reuteri), probiotic, secretes cytoplasmic membrane vesicles (CMVs) communicate with host cells, alter physiology, and alleviate dextran sulfate sodium (DSS)-induced colitis. First, L. reuteri-CMVs selectively promoted proliferation of beneficial bacterium...
Hoch geordnete, mesoporöse SiO2-Strukturen wurden durch Hydrothermalsynthese mit Fluoralkan/Alkan-Tensid-Mischungen als Templaten erhalten. Aufgrund der hohen Reaktionstemperatur ist die Silicatkondensation vollständig, und Produkte sind besonders stabil. JLU-20 z. B. (siehe TEM-Bild einer calcinierten Probe) hat eine vollständig kondensierte Porenwand einem Q4/Q3-Verhältnis von 6.5.
Highly ordered mesoporous silica materials are hydrothermally synthesized at high temperature by using fluorocarbon–hydrocarbon surfactant mixtures as templates. Because of the synthesis, obtained show complete condensation, which give rise to ultra-stabile structures. JLU-20 for example (see TEM image calcined JLU-20) has a fully condensed mesopore wall with very Q4/Q3 ratio 6.5.
Network pharmacology-based identification of key pharmacological pathways Yin–Huang–Qing–Fei capsule acting on chronic bronchitis Guohua Yu,1,2,* Yanqiong Zhang,2,* Weiqiong Ren,3 Ling Dong,1 Junfang Li,2,4 Ya Geng,2,5 Yi Zhang,2 Defeng Li,2 Haiyu Xu,2 Hongjun Yang2 1School Chinese Materia Medica, Beijing University Medicine, 2Institute China Academy Medical Sciences, Beijing, 3The First Affiliated Hospital Hunan Traditional Changsha, 4School Tianjin Tianjin, 5School Basic Shandong Jinan,...
Long non-coding RNAs (lncRNAs) are important regulators of many cellular processes, and their aberrant expression and/or function is associated with different diseases, including cancer. However, the identification functional lncRNAs in gastric cancer still a challenge. In this study, we describe novel lncRNA, linc00483, that upregulated tumorigenesis, tumour size, metastasis poor prognosis our linc00483 promoted cell proliferation, invasiveness vitro vivo. Mechanistically, acts as sponge to...
Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism yet to be elucidated. The aim of present study was clarify possible mechanisms. Dextran sulfate sodium‑induced colitis mice were treated with curcumin via gavage for 7 days. effects disease activity index (DAI) and pathological changes colonic tissue in determined. Interleukin (IL)‑6, IL‑10, IL‑17 IL‑23 expression levels measured by ELISA. Flow cytometry used detect ratio mouse spleen regulatory T cells...
Abstract Background Tandem C2 domains, nuclear (TC2N) is a domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem family, and acts as an oncogenic driver in several cancers. Previously, we preliminarily reported TC2N mediates PI3K-Akt signaling pathway inhibit tumor growth of breast cancer (BC) cells. Beyond that, its precise biological functions detailed molecular mechanisms BC development progression are not fully understood. Methods Tumor tissues 212 patients...
Irritable bowel syndrome (IBS) is a common chronic non-organic disease of the digestive system. Berberine (BBR) has been used to treat patients with IBS, but underlying therapeutic mechanism little understood. We believe that BBR achieves its effect on IBS by preventing stress intestinal inflammation and visceral hypersensitivity reducing motility.To test hypothesis subclinical mucosa motility.IBS was induced in rats via water avoidance (WAS). qRT-PCR histological analyses were evaluate...
Long non-coding RNA (lncRNA) LINC00460 is an onco-lncRNA in a variety of cancers, including pancreatic cancer (PC). This study aimed to investigate the regulatory mechanisms PC.The tumor and adjacent normal tissues were collected from 73 PC patients. The expression LINC00460, miR-503-5p, ANLN was detected using qRT-PCR. We then analyzed proliferation, migration, invasion, apoptosis/cell cycle cells by performing MTT/EdU, transwell, flow cytometry assays, respectively. xenograft model...