A5101871436- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Head and Neck Surgical Oncology
- Intensive Care Unit Cognitive Disorders
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Vagus Nerve Stimulation Research
- Anesthesia and Neurotoxicity Research
- Inflammation biomarkers and pathways
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- RNA Research and Splicing
- Circadian rhythm and melatonin
- Protein Tyrosine Phosphatases
- Infant Health and Development
- MicroRNA in disease regulation
- Ureteral procedures and complications
- Autophagy in Disease and Therapy
- Pediatric Urology and Nephrology Studies
- Management of metastatic bone disease
Army Medical University
2023-2025
Xinqiao Hospital
2023-2025
Army Medical College
2023
Air Force Medical University
2006-2022
Xijing Hospital
2006-2022
Second Affiliated Hospital of Zhejiang University
2018
First Affiliated Hospital of Xi'an Jiaotong University
2017
The objective of this study was to investigate whether serum anion gap (AG), which may serve as an indicator for multiple organic dysfunctions in the condition hypoxia, could be utilized a reliable prognostic marker short-term mortality and potential therapeutic target patients with acute respiratory distress syndrome (ARDS). A retrospective cohort conducted using data from Medical Information Mart Intensive Care (MIMIC-IV) electronic database (version 2.2), including 11,227 confirmed ARDS....
Abstract Background Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying regulation of microglial phenotypes after stroke remains unclear. Methods Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days reperfusion, effects activation and suppression triggering receptor expressed on myeloid cells 2 immunocyte (n = 5), neurobehavioral scores 7), infarct volumes 8), neuronal apoptosis 7)...
Abstract Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury. Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes (mtCB1R) and involved regulating functions under physiological conditions. However, whether mtCB1R affords neuroprotection against I/R injury remains unknown. We used mouse models of I/R, primary cultured hippocampal neurons exposed oxygen-glucose deprivation/reoxygenation (OGD/R) Ca 2+ -induced purified...
Abstract Background Tandem C2 domains, nuclear (TC2N) is a domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem family, and acts as an oncogenic driver in several cancers. Previously, we preliminarily reported TC2N mediates PI3K-Akt signaling pathway inhibit tumor growth of breast cancer (BC) cells. Beyond that, its precise biological functions detailed molecular mechanisms BC development progression are not fully understood. Methods Tumor tissues 212 patients...
Abstract We investigated whether glutamate receptor subunit 2 (GluR2) is involved in EA pretreatment-induced neuroprotection via cannabinoid CB1 receptors (CB1R) after global cerebral ischemia mice. Two hours electric acupuncture (EA) pretreatment, (GCI) was induced by bilateral common carotid artery occlusion (BCCAO) for 20 min. The GluR2 expression examined the hippocampus reperfusion. Cell survival, neuronal apoptosis, Bax/Bcl-2 ratio and neurological scores were evaluated at 24 h BCCAO...
Electroacupuncture (EA) pretreatment alleviates cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR). We attempted to investigate whether the phenotypic conversion of microglia was involved in therapeutic effect EA ischemia α7nAChR. Adult male Sprague Dawley (SD) rats were subjected middle artery occlusion (MCAO) after or α7nAChR agonist N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride (PHA-543,613 hydrochloride) and antagonist...
Abstract Recent studies have demonstrated microRNAs (miRNAs) and proteins are beneficial to axon regeneration, which may be involved in Electroacupuncture (EA) therapy against stroke. In this study, we aimed determine the pivotal role of PirB EA-produced rehabilitation ischemic stroke; screen investigate potential miRNAs directly regulating expression. The results showed EA treatment enhanced regeneration new projections from corticospinal tract at 28 d after cerebral reperfusion injury...
Abstract Background Tandem C2 domains, nuclear (TC2N) is a protein that has been characterized to contain C2A domain, C2B and short C-terminus with WHXL motif. In previous studies, we have uncovered the oncogenic role mechanisms of TC2N in lung cancer: achieves this by inhibiting p53 signaling pathway activating NF-kappaB pathway. Beyond that, its precise function tumorigenesis not fully understood. Methods TC2N-engineered mice model was used assess effect knockout on normal urethane-induced...
Propofol, dexmedetomidine, midazolam, and remimazolam are widely used for sedation during bronchoscopy. The purpose of this network meta-analysis was to compare the safety efficacy these four sedative drugs PubMed, Embase, Cochrane Libary, Wed Science databases were systematically searched collect randomized controlled trials (RCTs) propofol, bronchoscopy from inception database December 25, 2023. search strategy we (sedative subject terms or free terms) AND (bronchoscopy terms), without...
Our previous studies have shown that electroacupuncture (EA) enhances neurobehavioral functional recovery after ischemic stroke, however, the underlying regulatory mechanisms remain unclear. MicroRNAs (miRNAs) are abundant in brain and involved post-transcriptional gene regulation. During cerebral ischemia reperfusion, miRNAs perform numerous biological functions central nervous system related to regeneration repair of damaged nerves. also expression miRNA-132 (miR-132) is obviously...
Under pathological conditions, acupoint sensitization is the phenomenon of acupoints transforming from stable state to dynamic state. Evidences suggest that hyperpolarization-activated current (Ih), conducted by hyperpolarization-activated/cyclic nucleotide-gated (HCN) channel, greatly contributes peripheral and central sensitization. However, role Ih in has not been explained. In present study, changes excitability, density HCN channel dorsal root ganglion (DRG) nociceptive neurons were...
Acupuncture is widely used for knee osteoarthritis (KOA) treatment in clinical practice. In the present study, we aimed to set a standard KOA animal model electroacupuncture (EA) study and provide an acupuncture recipe further studies. Rats intra-articularly administered monosodium iodoacetate (MIA, 0.3, 1 or 3 mg respectively, n=12 each) were evaluated pain-like behavior: paw withdrawal mechanical threshold, weight bearing deficit, joint pathological changes (OARSI score) until 28 days...
Chemokine CX3CL1 and its receptor CX3CR1 in the lumbar spinal cord play crucial roles pain processing. Electroacupuncture (EA) is recognized as an alternative therapy treatment due to efficacy safety. However, analgesic mechanism of EA remains unclear. The aim this study was investigate whether suppressed complete Freund's adjuvant (CFA)-induced via modulating CX3CL1-CX3CR1 pathway.Inflammatory induced by intraplantar injection CFA left hind paw Sprague-Dawley rats. with 2 Hz for 30 mins...
Electroacupuncture (EA) administration before or after cerebral ischemia has been shown to afford protection against ischemic injury. However, the underlying mechanism of EA-mediated is still unclear. Functional microRNAs (miRNAs) are believed play important roles in neuroprotection and synaptic plasticity during ischemia. In a previous study, we identified 20 miRNAs that expressed penumbra significantly changed EA treatment. Here, used bioinformatic analysis predict biological functions...
The concept of “acupoint sensitization” refers to the functional status acupoint switches from silent active under pathological conditions. In clinic, sensitization provides important guidance for acupoints selection in different diseases. However, mechanism behind this phenomenon remains unclear. We generated a model knee osteoarthritis (KOA) by intra-articular injection monosodium iodoacetate (MIA) into left rats. paw withdrawal mechanical threshold (PWMT) and total number mast cells as...
Controlling aggression is a vital skill in social species such as rodents and humans has been associated with the medial prefrontal cortex (mPFC). In this study, we showed that during aggressive behavior, activity of GABAergic neurons prelimbic area (PL) mPFC was significantly suppressed. Specific activation PL curbed male-to-male inhibited conditioned place preference (CPP) for aggression-paired contexts, whereas specific inhibition brought about opposite effect. Moreover, projections from...
Objective: To evaluate the clinical application and effect of preseting Double-J ureteric stent in percutaneous nephrolithotripsy. Method: 74 cases renal calculi treated with PCNL our hospital during June 2014 to February 2017 were retrospectively analyzed. Of cases, 54 was male, 20 female. All aged 27 78, mean age (49.5±12.3) years old. The diameter stone 59 mm, (29.4±4.3) mm.Our Surgical methods first putingFr6 double J tube abnormal ureteral advance lithotomy position, then...
Abstract As the common complications observed in surgical elder patients, perioperative neurocognitive disorders (PND) cause a series of serious health problems. However, there are no effective treatments, and exact mechanisms still largely unknown. In this study, transcriptome sequencing was performed to investigate differentially expressed genes (DEGs)in hippocampus C57BL/6J aged mice with or without PND. Compared Mock group, expression 352, 395, 772 changed significantly PND group at day...