A5068806701- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Acupuncture Treatment Research Studies
- Acute Lymphoblastic Leukemia research
- Mechanisms of cancer metastasis
- S100 Proteins and Annexins
- Acute Myeloid Leukemia Research
- Pregnancy and Medication Impact
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Connexins and lens biology
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Vagus Nerve Stimulation Research
- Autoimmune and Inflammatory Disorders Research
- Endometriosis Research and Treatment
- Single-cell and spatial transcriptomics
Beijing University of Chinese Medicine
2022-2024
First Affiliated Hospital of Xi'an Jiaotong University
2018-2023
LMU Klinikum
2020-2023
Ludwig-Maximilians-Universität München
2020-2023
Klinik für Frauenheilkunde
2020
Qingdao University
2018-2019
Yuhuangding Hospital
2019
Affiliated Hospital of Qingdao University
2019
Nanjing University of Chinese Medicine
2015-2018
People's Hospital of Xinjiang Uygur Autonomous Region
2017
The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection against cerebral ischemic injury by activating receptors. novel receptor G protein-coupled 30 (GPR30) is highly expressed in the brain and acute stroke. However, underlying mechanisms remain unclear.In this study, ovariectomized female mice were subjected to middle artery occlusion (MCAO), E2, G1, ICI182780 administered immediately upon reperfusion. infarction volume, neurological scores, neuronal injuries examined....
Astrocytes possess different morphological characteristics depending on the cerebral region in which they are found. However, none of current astrocytic markers can label all subpopulations successfully. Thus, identifying appropriate marker for a specific scientific investigation is critical. Here, we compared distribution and protein expression three astrocyte markers: NDRG2, GFAP, S100 β , cortex, hippocampus, thalamus. NDRG2- -positive astrocytes were distributed more uniformly than...
Abstract Diabetes-associated cognitive impairment (DACI) can increase the risk of major cardiovascular events and death. Neuronal functionality is highly dependent on mitochondria emerging evidence has shown that mitochondrial transplantation a potential effective strategy reduce brain injury associated disorders. Platelets are abundant in blood be considered readily available source small-size mitochondria. These cells easily acquired from peripheral with minimal invasion via simple...
Dementia is a serious complication in patients with diabetes-associated cognitive dysfunction (DACD). In this study, we aim to explore the protective effect of exercise on DACD diabetic mice, and role NDRG2 as potential guarder for reversing pathological structure neuronal synapses.Seven weeks standardized at moderate intensity was carried out using an animal treadmill vehicle + Run STZ groups. Based quantitative transcriptome tandem mass tag (TMT) proteome sequencing, weighted gene...
Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition of high-mobility group box 1 release mechanism. This study investigated whether the signal transducer α7nAChR and NLRP3 inflammasome are involved in EA stimulus. In adult male Sprague-Dawley rats, focal was induced by middle artery occlusion (MCAO) models for 1.5 h. The expression...
The aim of this study was to investigate the cardioprotective effect salvianolic acid B (Sal B) on acute myocardial infarction (AMI) in rats and its potential mechanisms.The AMI model established Sal AMI. Haematoxylin-eosin (HE) staining used evaluate pathological change rats. Immunofluorescence TUNEL were detect autophagy apoptosis cells hearts rats, respectively. Protein expression apoptosis-related, autophagy-related angiogenesis-related proteins examined by Western blot.Sal attenuated...
Vitamin D plays critical role in the female reproductive system. It seems that vitamin is associated with clinical pregnancy outcomes of assisted technologies (ART), but its remains elusive. This study aimed to establish whether vitro fertilization (IVF). The cross-sectional was carried out from January 1st 2017 December 31st 2017. A total 848 patients who had indications for IVF were enrolled. classified by serum 25 (OH) quartiles. outcome parameters compared each group, including normal...
Premature ovarian insufficiency (POI) refers to a hypergonadotropic hypoestrogenism and the condition of pre-onset function failure. Epimedium is common traditional Chinese herbal medicine that widely used relieve POI in China. To systematically explore pharmacological mechanism epimedium on therapy, network pharmacology approach was conducted at molecular level.In this study, we adopt method, which mainly includes active ingredients prescreening, target prediction, gene enrichment analysis...
Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic worldwide. Si-Wu-Tang (SWT), traditional Chinese medicine decoction has shown therapeutic effects on various diseases. However, the hepatoprotective and underlying mechanism of SWT MAFLD remain unclear. Methods First, methionine-choline-deficient (MCD) diet-fed mice model was used lipidomic analysis transcriptomic were performed. The contents total iron ions, ferrous lipid peroxidation...
Abstract Previous studies of bone marrow-derived stem cell transdifferentiation into neurons have not involved purified populations and determined their exact phenotype prior to differentiation. The present study investigates whether highly mouse adult hematopoietic cells (HSCs), characterized by lineage marker depletion expression the surface markers Sca1 c-Kit (Lin− Sca1+ c-Kit+ [LSK]), can be stimulated adopt a neuronal fate. When HSCLSK were cultured in vitro differentiation medium...
Abstract Recent studies have demonstrated microRNAs (miRNAs) and proteins are beneficial to axon regeneration, which may be involved in Electroacupuncture (EA) therapy against stroke. In this study, we aimed determine the pivotal role of PirB EA-produced rehabilitation ischemic stroke; screen investigate potential miRNAs directly regulating expression. The results showed EA treatment enhanced regeneration new projections from corticospinal tract at 28 d after cerebral reperfusion injury...
Electroacupuncture (EA) pretreatment alleviates cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR). We attempted to investigate whether the phenotypic conversion of microglia was involved in therapeutic effect EA ischemia α7nAChR. Adult male Sprague Dawley (SD) rats were subjected middle artery occlusion (MCAO) after or α7nAChR agonist N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride (PHA-543,613 hydrochloride) and antagonist...
Diamond–Blackfan anemia (DBA) is a congenital red cell aplasia in which 25% of the patients have mutation ribosomal protein S19 (RPS19) gene. No models exist for RPS19-deficient DBA and molecular pathogenesis unknown. To establish an vitro inducible model DBA, human erythroid leukemic lines, TF-1 UT-7 cells, were cotransduced with lentiviral vector expressing green fluorescent (GFP) gene small interfering RNA (siRNA) against RPS19 controlled by tet operator regulatory element another...
Diamond–Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by specific deficiency in erythroid progenitors. Since some patients with DBA develop reduction thrombocytes and granulocytes age, we asked whether multipotent hematopoietic progenitors from had normal proliferative capacity liquid expansion cultures. CD34+ cells derived showed deficient proliferation culture containing IL-3, IL-6, SCF. Single CD38− exhibited recruitment limiting dilution assay SCF, Tpo,...