A5101516782- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Animal Virus Infections Studies
- Gynecological conditions and treatments
- Ovarian function and disorders
- Viral gastroenteritis research and epidemiology
- Ferroelectric and Piezoelectric Materials
- Viral Infections and Immunology Research
- Food Quality and Safety Studies
- Reproductive Biology and Fertility
- Long-Term Effects of COVID-19
- Endometrial and Cervical Cancer Treatments
- COVID-19 Clinical Research Studies
- Pelvic floor disorders treatments
- SARS-CoV-2 and COVID-19 Research
- Microwave Dielectric Ceramics Synthesis
- interferon and immune responses
- Immunotherapy and Immune Responses
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Physiology in Livestock
- Acute Myeloid Leukemia Research
- Thermochemical Biomass Conversion Processes
- Acoustic Wave Resonator Technologies
- Virus-based gene therapy research
- Computational Drug Discovery Methods
West China Second University Hospital of Sichuan University
2023-2024
Chengdu University
2024
Southwest University
2023-2024
Harbin Veterinary Research Institute
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Sichuan University
2023-2024
Yuhuangding Hospital
2012-2022
Qingdao University
2011-2022
University of Science and Technology Beijing
2022
Xi’an University of Posts and Telecommunications
2022
Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ~ 8,400 potential protein-encoding cDNA contigs from Schistosoma japonicum after sequencing circa 84,000 expressed sequence tags. In tandem, undertook high-throughput proteomics approach to characterize the protein expression profiles of number developmental stages (cercariae, hepatic schistosomula, female and male adults, eggs, miracidia) tissues at...
Vitamin D plays critical role in the female reproductive system. It seems that vitamin is associated with clinical pregnancy outcomes of assisted technologies (ART), but its remains elusive. This study aimed to establish whether vitro fertilization (IVF). The cross-sectional was carried out from January 1st 2017 December 31st 2017. A total 848 patients who had indications for IVF were enrolled. classified by serum 25 (OH) quartiles. outcome parameters compared each group, including normal...
Abstract Background Previous studies have shown that Coronavirus Disease 2019 (COVID-19) patients with underlying comorbidities can worse outcomes. However, the effect of hypertension on outcomes COVID-19 remains unclear. Research question The aim this study was to explore by using propensity score–matching (PSM) analysis. Study design and methods Participants enrolled in were who had been hospitalized at Central Hospital Wuhan, China. Chronic laboratory radiological data reviewed; patient...
Klebsiella pneumoniae is an important gram-negative bacterium that causes severe respiratory and healthcare-associated infections. Although antibiotic therapy applied to treat infections caused by K. pneumoniae, drug-resistant isolates pose a huge challenge clinical practices owing adverse reactions the mismanagement of antibiotics. Several studies have attempted develop vaccines against but there are no licensed available for control infection. In current study, we constructed novel DNA...
In the present study we describe a novel secreted protein, named C12ORF39 (chromosome 12 open-reading framework 39), which contains typical amidation/proteolytic processing signal (Gly-Arg-Arg motif). Interestingly, protein is not hydrolysed, but full-length without peptides. Western blotting indicated that c-Myc-tagged into culture medium in transfected HeLa cells. Quantitative RT-PCR (reverse transcription-PCR) analysis revealed c12orf39 mainly expressed placenta and brain....
Abstract The chemokine CXCL8, also known as the neutrophil chemotactic factor, plays a crucial role in mediating inflammatory responses and managing cellular immune reactions during viral infections. Porcine reproductive respiratory syndrome virus (PRRSV) primarily infects pulmonary alveolar macrophages (PAMs), leading to acute In this study, we explored novel long non-coding RNA (lncRNA), termed lnc-CAST, situated within Cxcl8 gene locus. This lncRNA was found be highly expressed porcine...
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious viral disease that causes substantial economic losses in the swine industry. This study aimed to develop PRRS virus (PRRSV) detection assay using multienzyme isothermal rapid amplification (MIRA) analyze genetic variation of PRRSV Southwest China. A total 13,863 samples, including blood lung tissues from pigs suspected infection, were collected. The MIRA was designed with primers probes targeting conserved regions...
Abstract Background Congenital cytomegalovirus (CMV) infection is the leading cause of sensorineural hearing loss (SNHL), and SNHL most frequent sequela congenital CMV infection. But pathogenic mechanism remains unknown, there no ideal intrauterine animal model to study mechanisms by which develops. Methods We established murine (MCMV) directly injecting virus into placenta on day 12.5 gestation. Then, we observed development MCMV rate fetuses they were born. Furthermore, detected auditory...
Nuclear factor E2-related 2 (NRF2) plays an anti-inflammatory role in several pathological processes, but its function lipopolysaccharide- (LPS-) induced goat endometrial epithelial cells (gEECs) is still unknown. We designed a study to investigate the of NRF2 LPS-induced gEECs. LPS was found increase expression and nuclear abundance gEECs dose-dependent manner. knockout (KO) not only increased proinflammatory cytokines (TNF-α, IL-1β, IL-6 IL-8) also TLR4, p-IκBα/IκBα, p-p65/p65 proteins....
Lactic acid bacteria (LAB) belong to a significant group of probiotic that provide hosts with considerable health benefits. Our previous study showed pigs abundant LAB had more robust immune responses in vaccination experiment. In this study, 52 isolate strains were isolated from the superior responses. Out these, 14 higher antibacterial efficacy chosen. We then assessed features strains, including such as autoaggregation, coaggregation, resistance, bile salt and adhesion capability, well...
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which classified into Ere-type and the less studied Est-type. In this study, we provide biochemical confirmation of EstX, an Est-type esterase that initially identified as unknown protein 1980s. EstX is capable hydrolyzing four 16-membered ring macrolides, encompassing both veterinary (tylosin, tidipirosin, tilmicosin) human-use (leucomycin A5)...
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly variable with genetic diversity. This study comparatively examines the pathogenicity immunological impact of two emergent PRRSV strains, SD53 HuN4, in piglets. Our results indicate that strain induces milder clinical syndromes less severe tissue damage than despite similar replication rates. Hematological tests showed perturbations peripheral blood cell profiles after infection, suggesting systemic impact. The...
Experiments on two-dimensional rectangular prisms with various side ratios (B/D=2, 3, and 4, where B is the along-wind dimension, D across-wind dimension) rounded corners (R/D=0%, 5%, 10%, 15%, R corner radius) are reported in this study. The tests were conducted low-turbulence uniform flow to measure wind pressures surfaces of 12 models for Reynolds numbers ranging from <TEX>$1.1{\times}10^5$</TEX> <TEX>$6.8{\times}10^5$</TEX>. aerodynamic force coefficients obtained by integrating pressure...
The present study investigated the effects of endometrial stem cell (EnSCs) transplantation combined with estrogen in repair injury. A total 30 patients intrauterine adhesions (IUA) and healthy individuals were selected. Expression epidermal growth factor (EGF) platelet-derived (PDGF)-BB tissue was assessed. Additionally, expression levels epithelial membrane antigen (EMA), cytokeratin (CK), integrin α-6 (CD49f), Thy-1 glycoprotein (THY-1), collagen type 1 (Col I), fibroblast (5B5) vimentin...
Objective Chronic endometritis (CE) contributes to impaired endometrial receptivity and is closely associated with poor in vitro fertilization (IVF) outcomes. However, the mechanisms underlying CE are unclear. Here, we investigated role of hypoxic microenvironment vascularization peri-implantation endometrium infertile women CE. Methods This retrospective study involved 15 fertile 77 patients diagnosed based on CD138+ ≥1/10 high-power fields (HPFs). The were divided into Group 1 (CD138+...
This study aimed to investigate the impact of hydrosalpinx fluid (HF) on early human embryonic development. A total 33 patients who underwent laparoscopic surgery for were selected, and HF specimens obtained from these subjected bacterial culture, Chlamydia antigen detection, biochemical analysis, cytokine detection. Meanwhile, embryos derived three pronuclei (3PN) cultured in various concentrations. There was no significant difference chemical components physical characteristics between...
To investigate the distribution and genetic variation in four vertically transmitted duck pathogens, including hepatitis B virus (DHBV), circovirus (DuCV), A 3 (DHAV-3), avian reoviruses (ARV), we conducted an epidemiology study using PCR RT-PCR assays on a population. We found that DHBV was most prevalent (69.74%), followed by DuCV (39.48%), then ARV (19.92%) DHAV-3 (8.49%). Among 271 samples, two, three or viruses were detected same indicating coinfection of vertical transmission agents is...
Summary Objective: We conducted the research in order to explore impact of hydrosalpinx fluid (HSF) on endometrium. Method: HSF group: 261 patients with scheduled undergo laparoscopic surgery 3 7 days after menstruation our center. Hysteroscopy would also be performed observe endometrial morphology during surgery. Sixty (60) randomly selected for biopsy detect inflammatory cytokines TNF-a and IL-2 mRNA. Non-HSF 210 no evidence due chronic salpingitis or pelvic adhesion. IVF-ET treatment was...
BACKGROUND:Endometrial regeneration is essential for normal endometrial function; however, it unclear whether and how menstrual blood-derived stem cells (MenSCs) platelet-derived growth factor (PGDF) are associated with this phenomenon. The present study explored topic. MATERIAL AND METHODS:EM-E6/E7/hTERT were divided into 5 groups: control group, NC PDGF MenSCs PDGF+MenSCs group. effects of on cell proliferation, invasion, microvascular formation epithelium investigated by CCK-8, Transwell,...