A5101471868- Cervical and Thoracic Myelopathy
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Prostate Cancer Treatment and Research
- Spinal Cord Injury Research
- Head and Neck Cancer Studies
- Hip and Femur Fractures
- Sirtuins and Resveratrol in Medicine
- Conducting polymers and applications
- Ginseng Biological Effects and Applications
- Nerve injury and regeneration
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Parasitic infections in humans and animals
- Traditional Chinese Medicine Analysis
- Bone health and osteoporosis research
- Antimicrobial Peptides and Activities
- Apelin-related biomedical research
- Pregnancy-related medical research
- Pelvic floor disorders treatments
- Viral gastroenteritis research and epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
Wenzhou Medical University
2023-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Suzhou Municipal Hospital
2024-2025
Nanjing Medical University
2022-2025
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Huazhong University of Science and Technology
2021-2023
Tongji Hospital
2021-2023
Qilu Hospital of Shandong University
2018-2023
Yangzhou University
2023
Abstract Background Hip fractures are associated with a high risk of death; among those who survive hip fracture, many experience substantial decreases in quality life. A comprehensive understanding the epidemiology and burden by country, age, gender, sociodemographic factors would provide valuable information for healthcare policymaking clinical practice. The Global Burden Disease (GBD) study 2019 was global-level estimating 369 diseases injuries 204 countries territories. An exploration...
Emerging evidence suggests that long non-coding RNAs (lncRNAs) are significant regulators in the pathological process of ischemic stroke (IS).However, little is known about lncRNAs and their roles IS.In this study, we aimed to screen out differentially expressed revealed underlying mechanisms IS.The results bioinformatic analysis showed lncRNA MEG3 Sema3A were overexpressed IS samples, while miR-424-5p was lower-expressed.Correlation between MEG3/miR-424-5p, miR-424-5p/Sema3A predicted with...
Inflammation plays a pivotal role in the pathogenesis of heart failure (HF). This study was aimed to potential association between complete blood cell count (CBC)-derived inflammatory biomarkers and HF.
The aim of this study was to investigate the cardioprotective effect salvianolic acid B (Sal B) on acute myocardial infarction (AMI) in rats and its potential mechanisms.The AMI model established Sal AMI. Haematoxylin-eosin (HE) staining used evaluate pathological change rats. Immunofluorescence TUNEL were detect autophagy apoptosis cells hearts rats, respectively. Protein expression apoptosis-related, autophagy-related angiogenesis-related proteins examined by Western blot.Sal attenuated...
Abstract Background Drug resistance of pathogens and immunosuppression are the main causes clinical stagnation osteomyelitis. The ideal treatment strategy for osteomyelitis is to achieve both efficient antibacterial bone healing through spatiotemporal modulation immune microenvironment. Methods In this study, a bilayer hydrogel based on genetically engineered polypeptide AC 10 A ARGD was prepared by self-assembly. Ag 2 S QDs@DSPE-mPEG 2000 -Ce6/Aptamer (AD-Ce6/Apt) loaded in top layer (AA)...
Heart failure (HF) and non-alcoholic fatty liver disease (NAFLD) are significant global health issues with a complex interrelationship. This study investigates their shared biomarkers causal relationships using bioinformatics Mendelian randomization (MR) approaches.
This study aimed to analyze the impact of preoperative cervical length before cerclage on extension gestational days in patients with various diagnostic types insufficiency, including obstetric history-based diagnosis, ultrasound-based and physical examination-based diagnosis. 168 were segregated into four categories based length: 0–0.4 cm, 0.5–1.4 1.5–2.4 ≥ 2.5 cm. Kaplan-Meier, linear regression curve Cox analyses used, a focus clinical variables, particularly duration after cerclage. The...
To explore the regulatory function and mechanism of CXCL14 in endometriosis. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to examine expression eutopic ectopic endometrial stromal cells (ESCs) derived from patients with endometriosis situ healthy individuals. Alterations cell proliferation migration capabilities were assessed through Cell Counting Kit-8 (CCK8) transwell assays following silencing or overexpression CXCL14. Mass spectrometry employed identify potential...
Escin, a natural triterpene saponin mixture obtained from the horse chestnut tree (Aesculus hippocastanum), has been used for treatment of chronic venous insufficiency (CVI), hemorrhoids, and edema. However, it is unclear how escin protects against endothelial barrier dysfunction induced by pro-inflammatory high mobility group protein 1 (HMGB1). Here, we report that can suppress (a) HMGB1-induced overexpression aquaporin-1 (AQP1) water channel in cells (b) increases cell permeability. This...
Background: Persistent prostate-specific antigen (PSA) after radical prostatectomy (RP) is associated with increased metastasis and mortality. However, the value of radiomics for predicting persistent PSA unclear. Our study aimed to evaluate diagnostic performance 18F-PSMA-1007 positron emission tomography (PET) multiparametric magnetic resonance imaging (mpMRI) prediction RP. Methods: Retrospective analysis was performed on 141 patients prostate cancer (PCa) who had undergone...
Naringenin (NGN) is a natural flavonoid that exerts antiinflammatory, antioxidant and cardioprotective effects. The present study investigated the effects of NGN on left ventricular hypertrophy in rats with NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension, sought to determine underlying mechanism action. received following by gavage daily for 56 days: L-NAME (50 mg/kg/day) + (100 mg/kg/day), saline, or saline saline. Blood pressure, heart rate body weight were recorded. Left...
The activation of microglia plays a crucial role in neuroinflammation. Previous studies have shown that cerebral dopamine neurotrophic factor (CDNF) has protective effect on neuroinflammation, but the mechanisms involved not been fully studied. AKT is serine-threonine protein kinase widely expressed mammals through which downstream pathway FoxO1/mTOR closely related to cell inflammation, apoptosis, metabolism, etc. Therefore, we examined whether CDNF regulates neuroinflammation this...
Abstract Fatty amide hydrolase (FAAH) is a key degradation enzyme of the endocannabinoid system, mainly responsible for hydrolysis arachidonic acid ethanolamine (AEA). Previous investigations have shown that FAAH involved in series biological processes, such as inflammation, immune regulation, and transmembrane signal transduction neurons. Endogenous cannabinoids cannabinoid receptors been reported to participate regulation bone homeostasis by regulating differentiation osteoblasts...
Spinal cystic echinococcosis, a severely neglected, rare disease, is characterized by high morbidity, disability, and mortality in prevalent regions. Due to the high-risk nature of surgical treatment ineffectiveness conventional drugs, there an unmet need for novel safe effective drugs this disease. In study, we examined therapeutic effects α-mangostin spinal explored its potential pharmacological mechanism. The repurposed drug exhibited potent vitro protoscolicidal effect significantly...
Objective. To determine whether arthrographic distention combined with manipulation for frozen shoulder provides additional benefits. Methods. A total of 180 participants from five clinical centers pain and stiffness in predominantly 1 >3 months entered the study, 165 completed study. The control group was treated alone, treatment underwent after resting 5 minutes following distention. Patients were followed up at one two weeks three six months. For evaluation, shoulder-specific...