A5052536733- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer, Stress, Anesthesia, and Immune Response
- Pregnancy and preeclampsia studies
- Inflammatory mediators and NSAID effects
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
- Pelvic floor disorders treatments
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Tea Polyphenols and Effects
- Peptidase Inhibition and Analysis
- Reproductive Biology and Fertility
- Galectins and Cancer Biology
- Ovarian function and disorders
- COVID-19 Impact on Reproduction
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Reproductive Health and Technologies
- Prostate Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2018-2025
Olgahospital
2020-2023
Klinik für Frauenheilkunde
2017-2022
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2017-2022
München Klinik
2021
Roland Mills United (Germany)
2018
Preliminary empirical data indicates a substantial impact of the COVID-19 pandemic on well-being and mental health. Individuals with minoritized sexual gender identities are at higher risk experiencing such negative changes in their well-being. The objective this study was to compare levels among cis-heterosexual individuals during pandemic. Using obtained cross-sectional online survey between April 20 July 20, 2020 (N = 2332), we compared (WHO-5) across subgroups (cis-individuals...
(1) Background: Biomarkers might play a significant role in predicting the clinical outcomes of patients with ovarian cancer. By analyzing lipid metabolism genes, future perspectives may be uncovered; (2) Methods: RNA-seq data for serous cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. non-negative matrix factorization package programming language R was used to classify molecular subtypes genes limma performed functional enrichment analysis. Through...
Macrophages are dynamic cells susceptible to the local microenvironment which includes tumor-associated macrophages (TAMs) in cancers. TAMs a collection of heterogeneous macrophages, including M1 and M2 subtypes, shaped by various activation modes labeled with markers different tumors. CCL22+-infiltrating thought be significantly associated prognosis cervical cancer patients. Moreover, CCL22 is an established marker M2a macrophages. Although phenotypic identification well mice human cultured...
The chemokine CCL22 recruits regulatory T (T-reg) cells into tumor tissues and is expressed in many human tumors. However, the prognostic role of cervical cancer (CC) has not been determined. This study retrospectively analyzed clinical significance expression FOXP3 230 patients. Immunohistochemical staining analyses were performed with a tissue microarray. Double immunofluorescence staining, cell coculture, ELISA used to determine expressing mechanisms. higher number infiltrating CCL22+...
(1) Background: The tumor microenvironment is involved in the growth and proliferation of malignant tumors process resistance towards systemic targeted therapies. A correlation between gene expression profile prognosis ovarian cancer patients already known. (2) Methods: Based on data from Cancer Genome Atlas (379 RNA sequencing samples), we constructed a prognostic 11-gene signature (SNRPA1, CCL19, CXCL11, CDC5L, APCDD1, LPAR2, PI3, PLEKHF1, CCDC80, CPXM1 CTAG2) for Fédération Internationale...
Abstract Introduction The COVID-19 pandemic drastically altered the way of life around world. Due to social distancing measures, contact restrictions and fears infection, has changed significantly. These measures along with stressors associated current worldwide situation, will inevitably have an effect on people's interpersonal personal behaviors. Aim This study evaluates nationwide German lockdown had sexual behavior cis men. Methods An anonymous web-based questionnaire was conducted among...
The aim of this retrospective study was to analyze the prognostic value cytoplasmic versus nuclear expression vitamin D receptor (VDR) in breast cancer (BC) tissue samples and relate results clinicopathological parameters. VDR assessed 319 primary patients using Remmele Stegner immunoreactive scoring (IRS) system. Follow-up data were obtained from Munich Cancer Registry. correlation with overall survival (OS) disease-free (DFS) calculated univariate multivariate analyses. Correlation...
One in fifty infants is conceived through assisted reproductive technologies (ART). To date, data on the cardiovascular morbidity of ART individuals ambiguous. This study investigated vascular function young subjects using 24 hour ambulatory blood pressure monitoring (24 h ABPM). and spontaneously controls matched age as well sex were enrolled. A profile including pulse wave analysis was executed all participants. Blood readings assessed every 15 min during daytime 30 nighttime. The...
Cervical cancer is primarily caused by the infection of high-risk human papillomavirus (hrHPV). Moreover, tumor immune microenvironment plays a significant role in tumorigenesis cervical cancer. Therefore, it necessary to comprehensively identify predictive biomarkers from immunogenomics associated with prognosis. The Cancer Genome Atlas (TCGA) public database has stored abundant sequencing or microarray data, and clinical offering feasible reliable approach for this study. In present study,...
The aim of this study was to evaluate the prognostic impact that hormone receptor (HR) expressions have on two different breast cancer (BC) entities-multifocal versus unifocal BC. As prognosis determining aspects, we investigated overall survival (OS) and disease-free (DFS) by univariate multivariate analysis. To underline study's conclusions, additionally considered histopathological grading tumor node metastasis (TNM) staging. A retrospective analysis performed survival-related events in a...
Preliminary research shows a substantial impact of the COVID-19 pandemic on women's sexual health, whereby empirical work well-being minoritized identities is still rare.The objective this study was to explore health in heterosexual, lesbian and bisexual cis women during first wave Germany.An anonymous nationwide online survey conducted among lockdown Germany from April 20th July 20th, 2020. The questionnaire distributed via e-mail, chats social-media platforms.Demographic variables...
Circulating tumour cells (CTCs) have been found to be a prognostic marker for reduced disease-free survival (DFS), distant DFS, breast cancer-specific survival, and overall (OS) before the start of systemic treatment. Determination CTCs with CellSearch System (Veridex, Raritan, NJ, USA) is valuable but time-consuming costly method. Therefore, aim this study was evaluate cytokine profiles as CTC involvement.Patients chosen were defined women cancer who agreed participate in phase I SUCCESS...
Background Over the past decades, assisted reproductive technologies (ART) have gained remarkable influence in treatment of infertility and account for more than 2 % births European countries nowadays. Accumulating evidence suggests ART to cause cardiovascular alterations, including left ventricular (LV) dysfunctions, within its offspring. The aim this study was assess LV systolic function subjects conceived through comparison spontaneously peers. Methods For assessment morphology function,...
Over 8 million individuals worldwide have been conceived through assisted reproductive technologies (ART). There is conflicting evidence on the cardiovascular health of ART offspring. This study aimed to investigate vascular function in a cohort children, adolescents and young adults compared spontaneously peers.Anthropometric variables, diet quality, level physical activity sedentary behavior were assessed. An extensive evaluation was conducted. Blood pressure as well endothelial evaluated....
The aim of this study was to assess the prognostic value steroid hormone receptor expression, counting retinoid X (RXR) and thyroid receptors (THRs), on two different breast cancer (BC) entities: multifocal/multicentric versus unifocal. overall disease-free survival were considered as prognosis determining aspects analyzed by uni- multi-variate analysis. Furthermore, histopathological grading TNM staging (T = tumor size, N lymph node involvement, M distant metastasis) examined in relation...
The aim of this study was to assess the security, value, and efficacy second-generation AdVance male sling XP (Boston Scientific®), after implementation in 2010 with advantageous modifications structure needle shape, a prospective multicenter long-term follow-up study.In total, 115 patients were included. Exclusion criteria earlier incontinence (UI) surgery, nocturnal UI, former radiotherapy, or night-time incontinence. We also excluded functional urethra <1 cm preoperatively performed...
Maternal immunological rejection of the semi-allogenic fetus is discussed as one significant factors involved in early pregnancy loss. An array cytokines secreted by both maternal and fetal cells generating a delicate immune tolerance. Interleukin-7 (IL-7) to play key role pro-inflammatory processes, but there still limited insight into pathophysiological input on placentation embryonic development loss.Cytokine level differences were identified with quantitative real-time PCR placental...
The present study aimed to investigate the influence of patients' and urologists' gender when choosing a urologist. With rising population diversity through immigration generational differences, patient-centered healthcare has recently moved focus European systems. As in urology often concentrates on sensitive topics, involves gender-specific diseases, research decision-making processes is high importance. Understanding choices real life would provide patients, physicians alike, with means...
Subjects conceived through assisted reproductive technologies (ART) potentially suffer from impaired left ventricular (LV) function due to premature vascular aging. This study aimed evaluate whether subtle differences in LV diastolic can be observed echocardiographically between young ART subjects and their spontaneously peers. The echocardiographic assessment included the measurement of dimensions, mitral inflow velocities, myocardial velocity at early diastole (E', cm/s) wall...