A5069004549- Science, Research, and Medicine
- Classical Antiquity Studies
- Byzantine Studies and History
- Historical, Religious, and Philosophical Studies
- Ancient Mediterranean Archaeology and History
- Classical Philosophy and Thought
- German Literature and Culture Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Biology and Fertility
- Genetics, Aging, and Longevity in Model Organisms
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Reproductive System and Pregnancy
- Archaeology and Historical Studies
- Birth, Development, and Health
- Historical, Literary, and Cultural Studies
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Sperm and Testicular Function
- Digital Humanities and Scholarship
- Genomics and Chromatin Dynamics
- Libraries and Information Services
- Biotechnology and Related Fields
LMU Klinikum
2025
Ludwig-Maximilians-Universität München
2025
Leipzig University
2012-2024
Universität Hamburg
2023-2024
University Medical Center Hamburg-Eppendorf
2023-2024
Max Planck Institute for Mathematics in the Sciences
2022
University of Lisbon
2022
Max Planck Institute for Mathematics
2022
Hertie Institute for Clinical Brain Research
2020
University of Tübingen
2020
Obese women tend to give birth overweight offspring who have a predisposition metabolic disease and obesity. This effect has now been reversed in mice by infusing pregnant mothers with adiponectin, hormone that helps manage metabolism [1]. The effects of maternal obesity on the fetus seem be mediated mainly through placenta, include increased transport nutrients across placenta as result elevated insulin signaling, leading excess fetal growth. There hints which is produced fat cells, might...
Objective To investigate accumulation of disability in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein‐antibody‐associated disease (MOGAD) a changing treatment landscape. We aimed to identify risk factors for the development milestones relation duration, number attacks, age. Methods analyzed data from individuals with NMOSD MOGAD German Neuromyelitis Optica Study Group registry. Applying survival analyses, we estimated computed time as defined by...
A study in mice points to a new approach preserving fertility female cancer patients. Chemotherapy can wreak havoc on DNA. The drugs damage the DNA of oocyte pool, resulting induction cell-death program and culling primordial oocytes, which provide lifetime’s supply eggs. consequence therapy women is often reduction ovarian reserve, impaired early menopause. Approaches preservation currently rely mainly freezing oocytes or tissue prior chemotherapy. But reproductive biologists have been...
Numerous studies have found that spontaneous, de novo mutations underlie a substantial proportion of cases cognitive disorders, from autism to intellectual disability (also known as mental retardation).But few these examined the source such mutations-do they come mother or father?An analysis copy number variations (CNVs) in large sample people with now pins most on father.What's more, certain CNVs were more often offspring older fathers.The findings bolster notion DNA replication during...
In earlyCaenorhabditis elegansembryos, production of new mRNAs is inhibited in the germ lineage. This inhibition requires germline factor PIE-1, and correlates with absence blastomeres a phosphoepitope on RNA polymerase II (RNAPII-H5). We show that PIE-1 uniformly distributed oocytes newly fertilized eggs, becomes localized asymmetrically late one-cell stage. To begin to dissect mechanisms required for localization RNAPII-H5 expression, we have examined distribution maternal-effect mutants...
The aim of this retrospective study was to analyze the prognostic value cytoplasmic versus nuclear expression vitamin D receptor (VDR) in breast cancer (BC) tissue samples and relate results clinicopathological parameters. VDR assessed 319 primary patients using Remmele Stegner immunoreactive scoring (IRS) system. Follow-up data were obtained from Munich Cancer Registry. correlation with overall survival (OS) disease-free (DFS) calculated univariate multivariate analyses. Correlation...
The cause of brain dysfunction during sepsis and septic encephalopathy is still under ongoing research. Sepsis induced changes in cerebral protein expression may play a significant role the understanding encephalopathy. aim present study was to explore proteome alterations rats. Fifty-six male Wistar rats were randomly assigned group (coecal ligature puncture, CLP) or control (sham). Surviving killed 24 48 hours after surgery whole-brain lysates used for two-dimensional gel electrophoresis...
Backgrounds: To establish nerve ultrasound reference data in 8 to 17 years-old children and adolescents compare those younger children, adults age-matched with polyneuropathies. Methods: High-resolution of the nerves was performed 117 healthy at 20 predefined landmarks neck extremities both sides. Mean values, side-to side differences intraneural ratios as well upper limits have been calculated. In a second step comparison 25 same age range proven hereditary acquired neuropathies lysosomal...
During the course of sepsis, heart and liver dysfunction occurs in 20-30 % patients. Both septic cardiomyopathy have a high mortality underlying molecular pathophysiology remains unclear. The present study investigated changes both cardiac protein expression after cecal ligature puncture (CLP) model rat sepsis during post-induction time 12, 24, 48 hours. After approval by local institutional review board, 62 male Wistar rats were assigned to three sham groups (n=16) (n=46). Rats control...