A5100694532- Mechanisms of cancer metastasis
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Circular RNAs in diseases
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Cancer, Hypoxia, and Metabolism
- Natural Compounds in Disease Treatment
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Stock Market Forecasting Methods
- Blood Pressure and Hypertension Studies
- Cancer-related cognitive impairment studies
- S100 Proteins and Annexins
- Time Series Analysis and Forecasting
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Metabolism, Diabetes, and Cancer
- Biological and pharmacological studies of plants
Tianjin Medical University
2012-2025
Jiangsu Vocational College of Medicine
2024
Guangdong Provincial People's Hospital
2024
Jinan University
2024
Shanghai Sixth People's Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Jiangnan University
2024
State Key Laboratory of Food Science and Technology
2024
Second Affiliated Hospital of Jilin University
2006-2024
Henan Cancer Hospital
2023
The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection against cerebral ischemic injury by activating receptors. novel receptor G protein-coupled 30 (GPR30) is highly expressed in the brain and acute stroke. However, underlying mechanisms remain unclear.In this study, ovariectomized female mice were subjected to middle artery occlusion (MCAO), E2, G1, ICI182780 administered immediately upon reperfusion. infarction volume, neurological scores, neuronal injuries examined....
Astrocytes possess different morphological characteristics depending on the cerebral region in which they are found. However, none of current astrocytic markers can label all subpopulations successfully. Thus, identifying appropriate marker for a specific scientific investigation is critical. Here, we compared distribution and protein expression three astrocyte markers: NDRG2, GFAP, S100 β , cortex, hippocampus, thalamus. NDRG2- -positive astrocytes were distributed more uniformly than...
Deep learning (e.g., Transformer) has been widely and successfully used in multivariate time series forecasting (MTSF). Unlike existing methods that focus on training models from a single modal of input, large language (LLMs) based MTSF with cross-modal text input have recently shown great superiority, especially limited temporal data. However, current LLM-based usually adapting fine-tuning LLMs, while neglecting the distribution discrepancy between textual tokens, thus leading to...
Abstract Background The prognosis of most hepatocellular carcinoma (HCC) patients is poor due to the high metastatic rate disease. Understanding molecular mechanisms underlying HCC metastasis extremely urgent. role CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate tumor suppressor gene, has not yet been explored in HCC. Methods mRNA protein expression was analyzed MHCC97H, Huh7 L-02 cells. Changes cell adhesion, migration invasion were detected by up- or down-regulating...
Previous studies presumed that the disturbed neurovascular coupling to be a critical risk factor of cognitive impairments in type 2 diabetes mellitus (T2DM), but distinct clinical manifestations were lacked. Consequently, we decided investigate T2DM patients by exploring MRI relationship between neuronal activity and corresponding cerebral blood perfusion. Degree centrality (DC) map amplitude low-frequency fluctuation (ALFF) used represent activity. Cerebral flow (CBF) was Correlation...
Abstract Gastric cancer (GC) is one of the most common malignancy and third leading cancer-related death in China. Long noncoding RNAs (lncRNAs) have been implicated numerous tumors, including GC, however, mechanism many functional lncRNAs still unclear. In this study, we identified abundantly expressed lncRNA, RP11-290F20.3, GC cells patient tumor tissues. We named lncRNA as GC-related lncRNA1 (GCRL1), which could regulate gastric cell proliferation metastasis, both vitro vivo....
Abstract The incidence of ischemic stroke is significantly increased in postmenopausal women. However, the neuroprotective effects estrogen replacement therapy (ERT) against remain controversial and role astrocytes ERT has rarely been explored. In this study, we investigated selective receptor (ER) agonists on activation neuronal apoptosis mice under conditions cell culture oxygen glucose deprivation reperfusion (OGD-R) global cerebral ischemia (GCI). We demonstrated that hippocampal...
The gut microbiome displays genetic differences among populations, and characterization of the genomic landscape in China remains limited. Here, we present Chinese Gut Microbial Reference (CGMR) set, comprising 101,060 high-quality metagenomic assembled genomes (MAGs) 3,707 nonredundant species from 3,234 fecal samples across primarily rural locations, 1,376 live isolates mainly lactic acid bacteria, 987 novel relative to worldwide databases. We observed region-specific coexisting MAGs with...
AimsVildagliptin promotes beta cell survival by inhibiting apoptosis. It has been suggested that chronic ER (endoplasmic reticulum) stress triggers The objective of the study is to explore whether pro-survival effect vildagliptin associated with attenuation endoplasmic reticulum in islets db/db mice.MethodsVildagliptin was orally administered mice for 6 weeks, followed evaluation apoptosis caspase3 activity and TUNEL staining method. Endoplasmic markers were determined quantitative RT-PCR,...
Lung cancer is the most commonly diagnosed type of and leading cause cancer-associated death worldwide. MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules ∼20–25 nucleotides in length. Single nucleotide polymorphisms a class genetic variation human genome, which when present miRNA genes associated with risk developing cancer. This study aimed to identify whether (miR)-608 polymorphism rs4919510 influenced incidence lung cancer, explore underlying mechanisms miR-608 pathogenesis...
Glutamate is a prominent neurotransmitter responsible for excitatory synaptic transmission and taken up by sodium-dependent amino acid transporters (EAATs) on astrocytes to maintain homeostasis. Here, we report that N-myc downstream regulated gene 2 (NDRG2), known tumor suppressor, required facilitate astroglial glutamate uptake protect the brain from excitotoxicity after ischemia. NDRG2 knockout (Ndrg2−/−) mice exhibited an increase in cerebral interstitial reduction into astrocytes. The...
Diabetic wounds exhibit retarded and partial healing processes. Therefore, patients are exposed to an elevated risk of infection. It has been verified that Angelica dahurica (Hoffm.) Benth. Hook. f. ex Franch. Sav ( A. ) is conducive for wound healing. However, the pharmacological mechanisms yet be established. The present study uses network pharmacology in vivo experimental validation investigate underlying process makes faster diabetes patients. 54 potential targets act on were identified...
Diabetic Cardiomyopathy (DCM) is a heart condition that arises specifically from diabetes mellitus, characterized by cardiac dysfunction in the absence of coronary artery disease or hypertension. The prevalence DCM rising tandem with global increase diabetes, necessitating development early diagnostic markers and therapeutic targets. This study integrates bioinformatics analysis experimental validation to identify potential biomarkers for DCM. We performed gene expression data mining Gene...
According to reports from China, esophageal cancer ranked sixth in terms of morbidity and accounted for 6.26% all cases China. This study aimed establish an effective prognostic nomogram non-adjuvant therapy patients with stage I III cancer. We took up 2010 2015 the Surveillance, Epidemiology, End Results (SEER) database used R language software perform Kaplan-Meier survival curve multivariate Cox regression analysis. Furthermore, we established predict 3- 5-year cancer-specific rate. The...
Coal-series kaolin flotation decarburization efficiency is greatly influenced by weathering. This study investigated the mechanisms which three typical types of weathering (short-term natural weathering, low-temperature oxidation and freeze–thaw weathering) affect surface characteristics floatability low-rank coal. Zeta potential measurements, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy contact angle analysis were performed to investigate these...
ABSTRACT Aim To explore the influence of serum total bilirubin to cholesterol (TBIL/TC) ratio on progression chronic kidney disease (CKD) in people with type 2 diabetes. Materials and Methods The present retrospective discovery cohort investigated 4282 patients. exposure was baseline TBIL/TC ratio. outcome first time progressing CKD, defined by a drop estimated glomerular filtration rate (eGFR) category, along reduction eGFR at least 25% compared value. Hazard ratios (HRs) for CKD were...
Introduction Alcohol-induced damage to bone microstructure leads alcoholic osteoporosis (AOP). While prior studies have demonstrated alcohol’s negative impact on density, the mechanisms by which alcohol induces through immune pathways, gut microbiota dysbiosis, and metabolic alterations remain insufficiently characterized. Given that is primarily absorbed in upper gastrointestinal tract, this research, we aimed elucidate role of spatial distribution disorders metabolites pathogenesis...
N-myc downstream-regulated gene 2 (NDRG2), a novel tumour suppressor and cell stress-related gene, is involved in many metabolic processes, such as hormone, ion fluid metabolism. We investigated whether NDRG2 any glucose-dependent energy metabolism, well the nature of its correlation with breast carcinoma.The correlations between expression glucose transporter 1 (GLUT1) clinical carcinoma tissues were analysed. The effects on uptake assessed cancer cells xenograft tumours. consequences...