Abstract Objectives The hypoxia-inducible factor 1-α (HIF1α), a key molecule in mediating bone-vessel crosstalk, has been considered promising target for treating osteoporosis caused by gonadal hormones. However, senile osteoporosis, with accumulated senescent cells aged bone, distinct pathogenesis. study aimed at revealing the unknown role of HIF1α thus broadening its practical application osteoporosis. Materials and methods Femurs tibias were collected from untreated mice various ages (2...

Non-thermal atmospheric plasma (NTAP) modification to induce a hydrophilic titanium (Ti) surface with less carbon contamination, has been demonstrated boost the osteogenic responses. In this study, we investigated underlying bone formation mechanism of NTAP-Ti, and involvement PI3K/Akt signaling pathway in regulating activities on NTAP-Ti surfaces. NTAP was employed for Ti activation, PI3K inhibitor, LY294002, applied suppression pathway. We systematically quantitatively detected cell...

Abstract Background: Human umbilical cord mesenchymal stem cells (hUCMSCs) are promising seed in bone tissue engineering. circRNA and N6-methyladenosine (m6A) RNA methylation play important roles osteogenic differentiation. Here, we investigated the potential relevance of a critical circRNA, hsa_circ_0003376 (circCTTN), methyltransferase-like 3 (METTL3) differentiation hUCMSCs. Methods: Expression circCTTN after hUCMSC induction was detected by qRT-PCR. Three databases (RMBase v2.0, BERMP,...

The study aims to analyze morphological variations and spatial distribution patterns of Krascheninnikovia compacta (Losinsk.) Grubov communities across 12 sampling areas at different elevations in the Tibetan antelope breeding grounds western Kunlun Mountains. Additionally, it projected future climatically suitabie habitats K. under climate change scenarios, aiming elucidate its community characteristics, dynamics, impacts global warming on growth. Integrated GIS, remote sensing, unmanned...

When subjected to extreme loads and ultra-low cycling conditions, the primary mode of failure in a ball screw is that excessive plastic contact deformation raceway surface exceeds acceptable limits. Consequently, traditional fatigue life theories based on pitting are not applicable this context. This study evaluated load distribution within screw, considering factors such as nut position length. The surfaces analyzed using Thornton’s elastoplastic theory. Furthermore, paper integrates...

The effect of a variety doping additives on the hydration resistance calcined materials in MgO–CaO system was investigated. Samples were prepared from lightly flotation magnesite that mixed with dolomite, as well analytically pure CaO and MgO; then, samples doped contained cations various valences (monvalent to tetravalent). Both rate powdering measured. important role higher‐valence improving revealed. This behavior is believed be due formation vacancies solid solutions or MgO cations. Ti...

Abstract In this paper, magnesia porous ceramics were prepared by particle‐stabilized foams assisted foam‐gel casting. Secondly, the performance of slurry and was investigated. The obtained powder manifested high adsorption amount excellent hydrophobicity, due to strong ability sodium dodecyl benzene sulfonate (SDBS) on particles. When SDBS concentration is .3 wt%, surface tension expansion ratio 45 mN·m −1 1.68, respectively. shape pore sphere cell structure, with uniform distribution pores...

The motion errors of hydrostatic lead screws can be smaller than the pitch due to averaging effect oil films, which is so-called on (AEPE). This paper investigates factors influencing AEPE under low speeds and a constant external load. An equivalent model with continuous helical recesses established, axial nut are obtained by combining dichotomy finite difference methods. results show that (a) caused screw have additivity, little influence errors, (b) when only has cumulative equal average...

The active controlled hydrostatic bearing is becoming more and popular because of its accuracy, safety, as well low vibration noise. In this paper, we present a design approach for thrust system, where the analytical nonlinear state space equation system established first, then three kinds control inputs are investigated compared to each other. It found that, by selecting supply pressure input, could obtain an affine which be linearized feedback linearization method, robustness enhanced...

With the application of sleeve bearing in high speed, super-high speed and narrow-gap conditions, emergence non-metallic materials, conventional no-slip boundary condition can be broken down. Critical shear stress is a main parameter numerical computation wall slip. The four modified Reynolds equations for two-dimensional spiral oil wedge established based on critical model, which circumferential axial slip surface are considered. angle used to compute component velocity. results show...

Poplar looper (Apocheima cinerarius Erschoff) is a destructive insect infesting Euphrates or desert poplars (Populus euphratica) in Xinjiang, China. Since the late 1950s, it has been plaguing Tarim Basin Xinjiang and caused widespread damages. This paper presents an approach to detection of poplar infestations on assessment severity using time-series MODIS NDVI data via wavelet transform discriminant analysis, middle lower reaches Yerqiang River as case study. We first applied time series...

To evaluate the clinical performance of two proposed onlay designs.Molars with occlusal and/or mesial/distal defects after root canal treatment were classified by design into three groups. Onlays without shoulders control group (Group C, n = 50). The designed onlays Group O (n 50) and mesio-occlusal/disto-occlusal MO/DO 80). All had an thickness approximately 1.5-2.0 mm, a shoulder depth width 1 mm. In Groups C O, box-shaped retention was 1.5 mm in depth. proximal box connected dovetail...

Hydration resistance of synthesized MgO–CaO clinker was improved by surface modification using oleic acid, stearic or complex acids as modifiers, with phosphoric acid a reference. Unmodified and modified samples were evaluated powdering test, weight change flowability test. The remarkable effects the modifiers on hydration manifested, modifier caused most significant effect. mechanism involved formation calcium‐containing films surfaces particles, which protected them from hydration. also...

This article investigates the axial static and dynamic characteristics of capillary-compensated hydrostatic lead screws with discontinuous helical recesses considering influence pitch errors nut. The mathematical model is based on Reynolds equation, including rotational lubricant inertia flow continuity equation. finite difference method perturbation technique are applied. results show that cause inequality recess pressures same flank surface nut thread; load capacity not significant within...

Hydrostatic lead screws possess superior motion characteristics and often run under high speeds variable loads. This paper presents research on the transient of capillary compensated hydrostatic with continuous helical recesses The model is based Reynolds equation, equation Euler takes pitch errors into account. simulation results show that: (a) displacement curves nut thread calculated lower static loads can be obtained approximately by translating curve no load, (b) higher loads, present...