A5022278084- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Metabolism and Genetic Disorders
- Advanced NMR Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Atomic and Subatomic Physics Research
- Cancer, Hypoxia, and Metabolism
- Congenital Heart Disease Studies
- Diet and metabolism studies
- Medical Imaging Techniques and Applications
- Neonatal Respiratory Health Research
- Traumatic Brain Injury Research
- MRI in cancer diagnosis
- Metabolomics and Mass Spectrometry Studies
- Thermal Regulation in Medicine
- Functional Brain Connectivity Studies
- NMR spectroscopy and applications
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
Children's Hospital of Los Angeles
2016-2025
University of Southern California
2015-2024
Keck Hospital of USC
2020-2022
Pediatrics and Genetics
2022
Los Angeles City College
2018
Cornell University
2017
RELX Group (Netherlands)
2017
Medical University of Vienna
2016
Nationwide Children's Hospital
2015
LAC+USC Medical Center
2014
Neonatal hypoxic–ischemic encephalopathy is an important cause of death as well long-term disability in survivors. Erythropoietin has been hypothesized to have neuroprotective effects infants with encephalopathy, but its on neurodevelopmental outcomes when given conjunction therapeutic hypothermia are unknown.
Abstract The objective of this study was to demonstrate 1 H MR spectroscopy (MRS) changes in cerebral metabolites after acute head trauma. Twenty‐five patients (12 children, 13 adults) were examined with quantitative MRS closed injury. Clinical grade (Glasgow Coma Scale [GCS]) and outcome (Rancho Los Amigos Medical Center Outcome Score [ROS]) correlated neurochemical findings. N‐acetylas‐partate (NAA), a neuronal axonal marker, reduced ( P < .03−.001). In NAA/creatine plus phosphocreatine...
Clinical trials involving patients with Duchenne muscular dystrophy are hindered by the lack of suitable objective end points. The purpose this study was to examine whether muscle lipid infiltration measured three-point Dixon MRI technique has value as a marker disease severity.Disease severity in nine boys (mean age, 8.6 +/- 2.7 years) determined functional ability scale Brooke and associates. Functional scores were compared strength measurements obtained manual testing muscles lower...
Institutional review board approval and informed consent were obtained for this study. This study was HIPAA compliant. The purpose of to visualize the movement cerebrospinal fluid (CSF) noninvasively by using an unenhanced magnetic resonance imaging technique. A time-spatial labeling inversion pulse (SLIP) technique applied label, or tag, CSF in a region interest. tagged clearly visualized at times 1500-4500 msec after both intracranial intraspinal compartments. Noninvasive visualization...
Between birth and late adolescence, the human brain undergoes exponential maturational changes. Using in vivo magnetic resonance spectroscopy, we determined developmental profile for 6 metabolites 5 distinct regions based on spectra from 309 children 0 to 18 years of age. The concentrations N-acetyl-aspartate (an indicator adult-type neurons axons), creatine (energy metabolite), glutamate (excitatory neurotransmitter) increased rapidly between 3 months, a period rapid axonal growth synapse...
Abstract Background In newborns with hypoxic-ischemic encephalopathy (HIE), the correlation between neonatal neuroimaging and degree of neurodevelopmental impairment (NDI) is unclear. Methods Infants HIE enrolled in a randomized controlled trial underwent MRI/MR spectroscopy (MRS) using harmonized protocol at 4–6 days age. The severity brain injury was measured validated scoring system. Using proportional odds regression, we calculated adjusted ratios (aOR) for associations MRI/MRS measures...
A non-invasive (13)C magnetic resonance spectroscopy (MRS) technique is described for the determination of N-acetyl-L-aspartate (NAA) synthesis rate, V(NAA), in human brain vivo. In controls, mean V(NAA) was 9.2 +/- 3.9 nmol/min/g. Canavan disease, where [NAA] increased (p < 0.001) and [aspartate] deceased 0.001), significantly reduced to 3.6 0.1 nmol/min/g 0.001). These rates are close agreement with activity biosynthetic enzyme measured vitro animals, rate urinary excretion NAA subjects...
Abstract In the brain, acetate is exclusively oxidized by glia. To determine contribution of glial metabolism to tricarboxylic acid cycle (TCA), 1‐ 13 C‐acetate was infused in six studies three normal adult subjects and one epileptic receiving valproic for seizure control. Ten grams 99% C labeled were intravenously as a 3.3% w/v solution over 60 min, during which vivo MR spectra brain acquired. As expected, label rapidly enriched cerebral bicarbonate, glutamate glutamine 5 . The mean rate...
<b>Objective: </b> To determine cerebral energy status in patients with Huntington9s disease(HD) and Parkinson9s disease (PD). <b>Methods: The study included 15 DNA-proven, symptomatic HD five medically treated, idiopathic PD, all of whom were candidates for neurotransplant treatment, as well 20 age-related normal subjects. Quantitative noninvasive, MRI-guided proton MRS was performed single volumes putamen basal ganglia (BG), occipital gray matter, posterior parietal white matter; addition,...
Abstract Rapid measurements of in vivo proton spin‐lattice relaxation times ( T 1 ) human tissues were performed by magnetic resonance imaging a 1.5 whole‐body super‐conducting MR scanner. The employ serial TurboFLASH (Snapshot‐FLASH) with scan for single experiment below 4 s. Using centric phase encoding order, an appropriate fitling the ‐parameter from images minimum motion artifacts is possible. Comparative ‐determination multipoint inversion recovery and spin‐echo technique was on...
Recent studies suggest a close local link between bone marrow adiposity and endosteal formation. Using magnetic resonance imaging, we examined whether the relation amount of fat cortical is present at multiple sites along diaphyses long bones young old males females.The relations values for area percent in each 5-mm section midthird both femoral shafts were determined using imaging eight healthy (aged <25 yr), nine >55 yr) men women.Strong inverse correlations observed all 34 femurs; r -0.54...
Medulloblastomas in children can be categorized into 4 molecular subgroups with differing clinical characteristics, such that subgroup determination aids prognostication and risk-adaptive treatment strategies. Magnetic resonance spectroscopy (MRS) is a widely available, noninvasive tool used to determine the metabolic characteristics of tumors provide diagnostic information without need for tumor tissue. In this study, we investigated hypothesis metabolite concentrations measured by MRS...
Childhood posterior fossa group A ependymomas demonstrate integrated metabolic and epigenetic pathways that can be disrupted by metformin.
Families and clinicians have limited validated tools available to assist in estimating long-term outcomes early after pediatric cardiac arrest. Blood-based brain-specific biomarkers may be helpful aid outcome assessment. To analyze the association of blood-based brain injury biomarker concentrations with 1 year The Personalizing Outcomes After Child Cardiac Arrest multicenter prospective cohort study was conducted intensive care units at 14 academic referral centers US between May 16, 2017,...
Objective. The purpose of this study was to use proton magnetic resonance spectroscopy (MRS) as a metabolic assay describe biochemical changes during the evolution neuronal injury in infants after shaken baby syndrome (SBS), that explain disparity between apparent physical and neurological deficit SBS. Methodology. Three [6 months (A), 5 weeks (B), 7 (C)] with SBS were examined repeatedly using localized quantitative MRS. Examinations performed on days 13 1, 3, 5, 12 19 (C) posttrauma....
PURPOSE: To retrospectively investigate whether quantitation of taurine (Tau) concentrations with proton magnetic resonance (MR) spectroscopy in vivo improves the differentiation primitive neuroectodermal tumors (PNET) from other common brain pediatric patients. MATERIALS AND METHODS: The institutional review board approved this clinical data; it was not necessary to obtain parental consent. This study HIPAA compliant. Single-voxel added preoperative MR imaging work-up 29 patients (12 boys...
Therapeutic hypothermia has emerged as the first empirically supported therapy for neuroprotection in neonates with hypoxic-ischemic encephalopathy (HIE). We used magnetic resonance spectroscopy ( 1 H-MRS) to characterize effects of on energy metabolites, neurotransmitters, and antioxidants. Thirty-one HIE were studied during after rewarming. Metabolite concentrations (mmol/kg) determined from thalamus, basal ganglia, cortical grey matter, cerebral white matter. In phosphocreatine increased...