A5034412293- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Cardiac Arrest and Resuscitation
- Ubiquitin and proteasome pathways
- Disability Education and Employment
- Viral-associated cancers and disorders
- Traumatic Brain Injury Research
- Click Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- 14-3-3 protein interactions
- Sarcoma Diagnosis and Treatment
University of Michigan
2019-2024
Michigan United
2024
Michigan Center for Translational Pathology
2024
Essen BioScience (United States)
2013
Boston University
2012
Iowa State University
2006-2009
Grinnell Newburg Community School District
2008
Little is known about the factors that shape employment-related decisions of individuals with intellectual and/or developmental disabilities. Findings from qualitative interviews individuals, their family members, and employment-support professionals four community rehabilitation providers throughout Massachusetts were reported. Recognizing value participatory action research, we also included a co-researcher disability who participated in all facets research process. revealed collection...
Peripheral T-cell lymphomas are clinically aggressive and usually fatal, as few complete or durable remissions achieved with currently available therapies. Recent evidence supports a critical role for lymphoma-associated macrophages during lymphoma progression, but the specific signals involved in cross-talk between malignant T cells their microenvironment poorly understood. Colony-stimulator factor 1 receptor (CSF1R, CD115) is required homeostatic survival of tissue-resident macrophages....
Families and clinicians have limited validated tools available to assist in estimating long-term outcomes early after pediatric cardiac arrest. Blood-based brain-specific biomarkers may be helpful aid outcome assessment. To analyze the association of blood-based brain injury biomarker concentrations with 1 year The Personalizing Outcomes After Child Cardiac Arrest multicenter prospective cohort study was conducted intensive care units at 14 academic referral centers US between May 16, 2017,...
Neoplasms originating from thymic T-cell progenitors and post-thymic mature subsets account for a minority of lymphoproliferative neoplasms. These derived neoplasms, while molecularly genetically heterogeneous, exploit transcription factors signaling pathways that are critically important in normal biology, including those implicated antigen-, costimulatory-, cytokine-receptor signaling. The factor GATA-3 regulates the growth proliferation both immature T cells has recently been most common...
Interleukin (IL)-2-inducible T cell kinase (ITK) is essential for receptor (TCR) signaling and plays an integral role in proliferation differentiation. Unlike the ITK homolog BTK, no inhibitors of are currently US Food Drug Administration (FDA) approved. In addition, recent studies have identified mutations within BTK that confer resistance to both covalent non-covalent inhibitors. Here, as alternative strategy, we report development BSJ-05-037, a potent selective heterobifunctional degrader...
Purpose: This paper describes a participatory research process in which six youth with disabilities (Youth Panel) participated the development and evaluation of manualized advocacy training, Project TEAM (Teens making Environment Activity Modifications). teaches how to identify environmental barriers, generate solutions, request accommodations. Method: The Youth Panel conducted their after university researcher implemented three groups trainees. designed administered survey focus group...
Importance Morbidity and mortality after pediatric cardiac arrest are chiefly due to hypoxic-ischemic brain injury. Brain features seen on magnetic resonance imaging (MRI) spectroscopy (MRS) may identify injury aid in outcome assessments. Objective To analyze the association of lesions T2-weighted MRI diffusion-weighted N-acetylaspartate (NAA) lactate concentrations MRS with 1-year outcomes arrest. Design, Setting, Participants This multicenter cohort study took place intensive care units at...
Abstract Purpose: Many peripheral and cutaneous T-cell lymphoma (CTCL) subtypes are poorly responsive to conventional chemotherapeutic agents associated with dismal outcomes. The zinc finger transcription factor GATA-3 the transcriptional program it instigates oncogenic highly expressed in various neoplasms. Posttranslational acetylation regulates DNA binding target gene expression. Given widespread use of histone deacetylase inhibitors (HDACi) relapsed/refractory CTCL, we sought examine...
Angiogenesis, the formation of new vessels from preexisting vessels, involves multiple cell types acting in concert to cause endothelial proliferation, migration, and differentiation into microvascular arrays. Under pathologic conditions, microenvironment changes result altered blood vessel production. Historically, vitro angiogenesis assays study individual aspects process tend be variable, difficult quantify, limited clinical relevance. Here, we describe a kinetic, quantitative, co-culture...
Peripheral T-cell lymphomas (PTCL) are agressive that develop from mature T cells. The most common PTCLs genetically, molecularly, and clinically diverse generally associated with dismal outcomes. While Notch signaling plays a critically important role in both the development of immature cells their malignant transformation, its PTCL is poorly understood, despite increasingly appreciated function regulating proliferation differentiation Here, we demonstrate receptors Delta-like family...
The reciprocal relationship between malignant T cells and lymphoma-associated macrophages (LAM) within the tumor microenvironment (TME) is unique, as LAMs are well poised to provide ligands for antigen, costimulatory, cytokine receptors that promote T-cell lymphoma growth. Conversely, functional polarization homeostatic survival of LAM. Therefore, we sought determine extent which a therapeutic vulnerability in these lymphomas, identify effective strategies their depletion. We utilized...
The literature has indicated that faculty and administrators are often uncertain about how to foster effective mentoring relationships with undergraduate students. This study analyzed the functions of in College Agriculture Life Sciences at Iowa State University regarding process. Six (informal contact, role modeling, direct assistance, demonstration, assistance professional development plans, observation feedback) were identified literature. A previous questionnaire was used measure extent...
<div>AbstractPurpose:<p>Peripheral T-cell lymphomas are clinically aggressive and usually fatal, as few complete or durable remissions achieved with currently available therapies. Recent evidence supports a critical role for lymphoma-associated macrophages during lymphoma progression, but the specific signals involved in cross-talk between malignant T cells their microenvironment poorly understood. Colony-stimulator factor 1 receptor (CSF1R, CD115) is required homeostatic...
<p>BHLHE40 and KLF6 are transcriptionally activated by GATA-3, their expression impaired upon HDAC inhibition</p>
<p>HDACi alters GATA-3 target genes expression in independent datasets</p>
<p>ChlP-seq occupancy binding peaks at GATA-3 target genes in vehicle/HDACi treated H9 cells</p>
<p>BHLHE40 and KLF6 are transcriptionally activated by GATA-3, their expression impaired upon HDAC inhibition</p>