A5107967182- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- AI in cancer detection
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Digital Imaging for Blood Diseases
- Immune Cell Function and Interaction
- Renal and related cancers
- Renal cell carcinoma treatment
- Migration, Aging, and Tourism Studies
- Viral-associated cancers and disorders
- Breast Cancer Treatment Studies
- Chronic Kidney Disease and Diabetes
- Immunotherapy and Immune Responses
- Eosinophilic Disorders and Syndromes
- Vascular Tumors and Angiosarcomas
- Erythrocyte Function and Pathophysiology
- Chemokine receptors and signaling
- Breast Lesions and Carcinomas
- Multiple Myeloma Research and Treatments
New York Medical College
2024-2025
Westchester Medical Center
2024
McLaren Health Care
2023
Comprehensive Urology
2023
Beth Israel Deaconess Medical Center
2009-2020
Harvard University
2009-2020
University of Michigan
2015-2020
Michigan Medicine
2019
University Medical Center
2015
Northwestern University
2015
Increased numbers of S100A4 + cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities cancer been examined, functional role stromal metastasis is largely unknown. To study contribution metastasis, we used transgenic mice that express viral thymidine kinase under control promoter to specifically ablate cells. Depletion significantly reduced colonization without affecting primary tumor growth. Multiple bone marrow transplantation studies...
Paper diagnostics have successfully been employed to detect the presence of antigens or small molecules in clinical samples through immunoassays; however, detection many disease targets relies on much higher sensitivity and specificity achieved via nucleic acid amplification tests (NAAT). The steps involved NAAT recently begun be explored paper matrices, our group, among others, has reported paper-based extraction, amplification, DNA RNA targets. Here, we integrate these into a single...
Endothelial-to-mesenchymal transition (EndMT) is a cellular transdifferentiation program in which endothelial cells partially lose their identity and acquire mesenchymal-like features. Renal capillary can undergo EndMT association with persistent damage of the renal parenchyma. The functional consequence(s) kidney fibrosis remains unexplored. Here, we studied effect Twist or Snail deficiency on fibrosis. Conditional deletion Twist1 (which encodes Twist) Snai1 Snail) VE-cadherin+ Tie1+...
Abstract Context.—Numerous immunohistochemical stains have been shown to exhibit exclusive or preferential positivity in breast myoepithelial cells relative their luminal/epithelial counterparts...
Peripheral T-cell lymphomas are clinically aggressive and usually fatal, as few complete or durable remissions achieved with currently available therapies. Recent evidence supports a critical role for lymphoma-associated macrophages during lymphoma progression, but the specific signals involved in cross-talk between malignant T cells their microenvironment poorly understood. Colony-stimulator factor 1 receptor (CSF1R, CD115) is required homeostatic survival of tissue-resident macrophages....
Cervical cancer is one of the leading causes death in women. Screening at early stages using popular Pap smear test has been demonstrated to reduce fatalities significantly. Cost effective, automated screening methods can significantly improve adoption these tests worldwide. Automated involves image analysis cervical cells. Gaussian Mixture Models (GMM) are widely used processing for segmentation which a crucial step analysis. In our proposed method, GMM implemented segment cell regions...
Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new therapeutic strategies. We others have previously established bortezomib, a selective proteasome inhibitor, an important potential treatment CML. Here we show that the combined regimens bortezomib with mitotic inhibitors, microtubule-stabilizing agent Paclitaxel PLK1 inhibitor BI2536, efficiently kill TKIs-resistant -sensitive...
BCR-ABL is a key mediator in the pathogenesis of all cases chronic myelogenous leukemia (CML) and subset precursor B-acute lymphoblastic (Ph+ALL). Previous animal cell-based studies have shown that expression members Forkhead family tumor suppressors, including FoxO3, suppressed BCR-ABL-expressing cells. Furthermore, it has been reported proteasomal degradation pathway plays an important role suppression FoxO BCR-ABL-transformed In this study, patient diagnosed with Ph+ALL refractory to...
Partial tandem duplication (PTD) of the KMT2A (MLL) gene is detected in approximately 5-10% cases acute myeloid leukemia (AML)[1][1]–[5][2] and within showing normal karyotype, confers a worse prognosis.[2][3],[6][4],[7][5] In these patients, duplications are variable size
One of the objectives in development effective cancer therapy is induction tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cells via TAT cell-delivery system, shows remarkably potent cytoxicity variety lines and inhibits tumor growth vivo, whereas sparing normal tissues. This fusion was named killerFLIP as its sequence derived from C-terminal domain c-FLIP, an anti-apoptotic protein. Using structure activity analysis, determined...
To the Editor.—The potential for a laboratory-acquired SARS-CoV-2 infection, causing COVID-19 disease, from accidental exposure grows as pandemic progresses, making biosafety of samples during transportation and laboratory diagnosis vital. Therefore, Centers Disease Control Prevention's (CDC) recommendation to transport diagnostic specimens in viral media (VTM) that preserve viability infectivity virus is unexpected.1 Additionally, some health care professionals personnel may not be aware...
We describe the case of a 44-year-old woman with primary Burkitt lymphoma heart who presented abdominal bloating and epigastric discomfort secondary to tamponade physiology caused by large pericardial effusion. The fluid contained number highly atypical lymphocytes moderate basophilic cytoplasm, rare punched-out vacuoles, vesicular nuclear chromatin, nucleolus, marginated chromatin that FISH were positive for 8;14 translocation. She had no other sites disease. was treated four alternating...
An estimated 1.2 to 2.3 million Hindus live in the United States. End-of-life care choices for a subset of these patients may be driven by religious beliefs. In this article, we present Hindu beliefs that could strongly influence devout person's decisions about medical care, including end-of-life care. We provide four case examples (one sacred epic, one historical example, and two cases from current practice) illustrate notions surrounding pain suffering at end life. Chief among those is...
How pathologists communicate an error is complicated by the absence of a direct physician–patient relationship. Using 2 examples, we elaborate on how other physician colleagues routinely play intermediary role in our day-to-day transactions and communication pathologist to patient. The concept “dual-hybrid” mind-set its representing pathologists’ viewpoint adequately considered. In dual-hybrid mind-set, can align with patients’ philosophy like patient, consider smallest deviation from norm...
A 77-year-old man with history of Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma without bone marrow involvement which was treated involved field radiation in complete remission for 7 years. He presented April 2010 a fall and right knee pain. Magnetic resonance imaging (MRI) June showed meniscal tear abnormal signal the tibial plateau. Persistent pain prompted biopsy proximal tibia. Hematoxylin eosin stain dense infiltrate intermediate to large-sized...
We report an index case of histiocytic sarcoma arising in a 70-year-old patient with long-standing chronic lymphocytic leukemia/small lymphoma (CLL/SLL). The presented 2017 painful, enlarging swelling the left neck. He had remote history cutaneous squamous cell carcinoma no sign recurrence, and his CLL/SLL was thought to be remission. Computed tomography showed mild splenomegaly multifocal lymphadenopathy including 3-cm neck mass. Biopsy mass associated sarcoma. Flow cytometry demonstrated B...
Chronic myeloid leukemia (CML) is typically characterized by leukocytosis including left-shifted neutrophilia, basophilia, eosinophilia, and variable thrombocytosis. However, extremely rare cases of CML patients without significant thrombocytosis (aleukemic phase CML, or CML-ALP) have been reported. Due to its rarity limited awareness, knowledge gaps persistent in terms the pathologic diagnosis, disease progression, optimal patient management outcomes. In this multi-institutional study, we...