A5100696778- Pesticide Residue Analysis and Safety
- Analytical Chemistry and Chromatography
- Diabetic Foot Ulcer Assessment and Management
- Analytical chemistry methods development
- Insect and Pesticide Research
- Oxidative Organic Chemistry Reactions
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Metabolomics and Mass Spectrometry Studies
- Aerodynamics and Fluid Dynamics Research
- Marine Sponges and Natural Products
- Antibiotics Pharmacokinetics and Efficacy
- Transportation Planning and Optimization
- Pharmacological Effects and Assays
- Occupational Health and Safety Research
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Advanced Chemical Sensor Technologies
- Enzyme Catalysis and Immobilization
- Wind and Air Flow Studies
- Food Quality and Safety Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Sichuan University
2010-2025
West China Hospital of Sichuan University
2010-2025
China National Center for Food Safety Risk Assessment
2016-2025
Anhui Medical University
2014-2025
First Affiliated Hospital of Anhui Medical University
2014-2025
Fujian Electric Power Survey & Design Institute
2023-2025
Ministry of Education of the People's Republic of China
2025
Shihezi University
2025
Shanghai Dianji University
2024
Neonicotinoid insecticides are ubiquitous in food and the environment due to their wide use. Growing evidence suggests adverse effects of neonicotinoids many species, including mammals. Some studies have reported urinary concentrations human biological monitoring, but potential risks on health based long-term chronic exposure any general population been rarely tackled. In this study, dietary Chinese adult was studied basis composite samples collected from 5th (2009–2012) 6th (2015–2018)...
Behavior Based Safety (BBS) is one effective method on accident prevention widely applied by Europe and American countries since1980s, however little research application carried out in China. The experiment course of BBS was designed this paper for China construction enterprise based situation. Index (SI) change trend chart established SI used to evaluate safety behavior trend. results showed that made remarkable performance the trial employee's enhanced 15% than base line during...
Oxetane synthase (TmCYP1), a novel cytochrome P450 enzyme from Taxus×media cell cultures, has been functionally characterized to efficiently catalyse the formation of oxetane ring in tetracyclic taxoids. Transient expression TmCYP1 Nicotiana benthamiana using 2α,5α,7β,9α,10β,13α-hexaacetoxytaxa-4(20),11(12)-diene (1) as substrate led production major derivative, 1β-dehydroxybaccatin IV (1 a), and minor 4β,20-epoxide baccatin I b). However, feeding decinnamoyltaxinine J (2), 5-deacetylated...
Lysine 2,3-aminomutase (LAM) catalyzes the interconversion of l-lysine and l-β-lysine, by a radical mechanism initiated reversible, reductive homolytic scission C5'−S bond in S-adenosylmethionine (SAM) to form methionine 5'-deoxyadenosyl at active site. LAM is member superfamily enzymes which [4Fe-4S]+ cluster with unique, noncysteinyl coordinated Fe provides electron required cleavage SAM. Little known inserted into SAM, it not whether all family employ same mechanism. Selenium X-ray...
The phosphatidylinositol 3-kinase (PI3K) pathway plays an important role in many biological processes, including cell cycle progression, growth, survival, actin rearrangement and migration, intracellular vesicular transport. However, the involvement of PI3K regulation mitotic death remains unclear. In this study, we treated HeLa cells with inhibitors, 3-methyladenine (3-MA, as well a widely used autophagy inhibitor) wortmannin to examine their effects on fates using live imaging. Treatment...
Fifteen new guaiazulene-based terpenoids designated anthogorgienes A–O (1–15) were isolated from a Chinese gorgonian Anthogorgia sp., together with eight known analogues (16–23). The structural patterns classified into monomers, dimers, and trimers, which supposed to be generated precursor guaiazulene followed by side-chain nucleus oxidation oxidative rearrangement. structures of compounds elucidated on the basis extensive spectroscopic (IR, MS, 1D 2D NMR) data analysis. A possible...
A simple, rapid, sensitive, selective, and environmentally friendly method, based on a dispersive micro solid-phase extraction approach (dispersive SPE) coupled with liquid chromatography–high-resolution mass spectrometry (LC-HRMS), was established for the analysis of sulfonamides in honey milk. An efficient nontargeted screening strategy designed to discover identify known unknown milk using full-MS/all ion fragmentation (AIF) acquisition mode. The experimental parameters conditions SPE...
In the present study, a green and efficient extraction method using deep eutectic solvents as solvent was developed for extracting four major active compounds narirutin, naringin, hesperidin neohesperidin from Aurantii Fructus.A series of tunable were prepared investigated by mixing choline chloride or betaine to different hydrogen-bond donors, betaine/ethanediol found be most suitable solvent. To achieve best yield, primary factors affecting efficiency, such acceptor/hydrogen-bond donor...
Presently, the potential health risks of neonicotinoid insecticides (neonics) are now receiving much attention, but no data regarding exposure infants to neonics via human breast milk intake have been reported. In this study, a nationwide survey was conducted during period 2017–2019, wherein 97 pooled samples were collected from 3570 lactating women 23 provinces in China. Nationally, acetamiprid-N-desmethyl most predominant compound, accounting for 61.2% total amount neonics, followed by...
Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita among predominant causes of fatal food poisoning China. In treatment mushroom poisoning, an early definite diagnosis is necessary for a successful outcome, which has prompted development protocols fast confirmatory determination amatoxins human biological fluids. For this purpose, simple, rapid sensitive multiresidue UPLC-MS/MS method simultaneous α-amanitin, β-amanitin, γ-amanitin, phalloidin (PHD) phallacidin...
Fipronil, as an emerging phenylpyrazole insecticide, is ubiquitous in the environment and food due to its broad spectrum persistent characteristics, but research on pathways of human exposure fipronil associated health risk relatively unclear. In this regard, we summarize potential exposures through ingestion inhalation, well results biomonitoring studies. This scientific information will contribute future assessment subsequent characterization risks. Additionally, Perspective highlights...
Trichoderma spp., which widely exist in nature, are always used as plant growth-promoting stimulants. However, there is little reporting about the combined use of strains to promote growth plants. We explored two different (Trichoderma atroviride LX-7 and citrinoviride HT-1) a mixture on effects pakchoi. In this study, vitro-promoting traits were determined, six treatments used: T. LX-7, HT-1, mixtures these (1:1, 1:2 2:1) no inoculation seed germination pot experiment. The results showed...
AimsA high proportion of all patients with tuberculosis (TB) present extrapulmonary TB (EPTB), including concurrent EPTB involving more than one lesion site. However, previous reports only characterized lesions single-site cases. This study aimed to investigate epidemiological characteristics and association rules cases in China.MethodsAn observational multi-centre 208,214 was undertaken China from January 2011 December 2017. Multi-variable logistic regression analysis used identify...
What is the potential of applying non-invasive preimplantation genetic testing (niPGT) for chromosome abnormalities in blastocysts reported with a mosaic trophectoderm (TE) biopsy?niPGT cell-free DNA blastocyst culture medium exhibited good diagnostic performance putative blastocysts.Advances niPGT have demonstrated reliability as resource assessment, but information on embryos scarce because mosaicism may interfere niPGT. In addition, high incidence context PGT and viability raise questions...
Campylobacter is a major cause of bacterial foodborne diarrhea worldwide. Consumption raw or undercooked chicken meat contaminated with the most common causative agent human infections. Given high prevalence contamination in poultry and recent rise multi-drug-resistant (MDR) strains, an effective intervention method reducing bird colonization food-processing needed. In this study, Campylobacter-specific lytic phage CP6 was isolated from feces. strongly infected MDR isolates retail meats. It...
Abstract Aims Pedal medial arterial calcification (MAC) is frequently observed in individuals with diabetic foot ulcers (DFUs). However, the impact of pedal MAC on DFUs remains uncertain. The main aim this study was to evaluate association between amputation and mortality outcomes. Methods A prospective, observational cohort conducted at West China Hospital from January 2012 December 2021. Logistic regression analyses, Kaplan–Meier survival method, Cox proportional hazards models were...