A5033461362- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Pediatric Hepatobiliary Diseases and Treatments
- Pregnancy and preeclampsia studies
- Liver Disease and Transplantation
- Evacuation and Crowd Dynamics
- Liver Diseases and Immunity
- Neonatal Respiratory Health Research
- Prostate Cancer Treatment and Research
- Genomics and Rare Diseases
- Gestational Diabetes Research and Management
- Infection Control in Healthcare
- Birth, Development, and Health
- Acute Kidney Injury Research
- Global Maternal and Child Health
- Traffic control and management
- Maternal Mental Health During Pregnancy and Postpartum
- Preterm Birth and Chorioamnionitis
- Cardiovascular Issues in Pregnancy
- Bariatric Surgery and Outcomes
- Genetics, Bioinformatics, and Biomedical Research
- Artificial Intelligence in Healthcare
- Elbow and Forearm Trauma Treatment
Chinese PLA General Hospital
2019-2024
Chinese People's Liberation Army
2022-2023
Beijing Ditan Hospital
2019-2023
Capital Medical University
2019-2023
State Council of the People's Republic of China
2021
American Journal Experts (United States)
2020
Xingtai People's Hospital
2020
Hebei Medical University
2020
302 Military Hospital of China
2016-2018
National Institute for Communicable Disease Control and Prevention
2018
Abstract Background and Aims Functional cure is difficult to achieve using current antiviral therapies; moreover, limited data are available regarding treatment outcomes in children. This retrospective study aimed assess the frequency of functional among children undergoing for active chronic hepatitis B (CHB). Methods A total 372 aged 1–16 years, with CHB were enrolled underwent either nucleos(t)ide analog monotherapy or combination therapy interferon-α (IFN-α) 24–36 months. All attended...
Abstract Background ABCB4 gene-related cholestatic liver diseases have a wide spectrum of clinical and genetic variations. The correlation between genotype phenotype still unclear. This study retrospectively analyzed the pathological characteristics 23 patients with diseases. Next-generation sequencing was used to identify causes. Results included (15 children 8 adults) were diagnosed as progressive familial intrahepatic cholestasis type 3 (PFIC3), drug-induced injury (DILI), cirrhosis...
Background . Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension preeclampsia. It widely accepted that the placenta plays crucial role in development Our aim explore effect metformin on Study Design We examined control diet-fed (isocaloric diet) pregnant mice (CTRL group), fed high-fat diet (HF high-fat-diet-fed treated (HF-M group). The HF were six weeks before pregnancy establish preeclampsia-like model; then,...
There is a lack of data supporting the notion that antiviral treatments can benefit children with chronic hepatitis B (CHB) having high viremia and normal or mildly elevated serum alanine aminotransferase (ALT) levels. We aimed to analyze efficacy in CHB explore factors associated functional cure.Forty-eight ALT levels were screened this real-world study. Thirty-two received either interferon-alpha (IFN-α) monotherapy, IFN-α therapy nucleoside analog (NA) add-on, NA combination therapy. The...
This study aimed to compare the diagnostic accuracy of transient elastography (TE) and biopsy for detection liver fibrosis in children with chronic hepatitis B (CHB).This single-center prospective included 157 CHB aged 0-6 years. All patients underwent stiffness measurement (LSM) by TE biopsy, separated an interval less than 1 week.The LSM, aspartate aminotransferase-platelet ratio index (APRI), fibrosis-4 (FIB-4) were positively correlated activity grade stage children. The areas under...
Osteosarcoma (OS) is a progressive primary bone tumor that originates from immature stromal spindle cells. After chemotherapy, the serum-related indexes which are related to prognosis.The aim of this study investigate correlation between changes in serum cyclooxygenase-2 (COX-2), basic fibroblast growth factor (bFGF), vascular endothelial (VEGF), transforming factor-beta (TGF-β), and tumor-specific (TSGF) levels prognosis patients with osteosarcoma before after treatment.Data 75 OS...
Alagille syndrome (ALGS) is a multisystem genetic disorder frequently characterized by hepatic manifestations. This study analyzed the clinical, pathological, and molecular features of ALGS to improve efficiency clinical diagnosis.
To evaluate the differences in agreement between wedged hepatic venous pressure (WHVP) and portal (PVP) at different gradient (HVPG) levels to identify specific HVPG thresholds where WHVP can reliably estimate PVP, thus enhancing accuracy of risk stratification treatment decision-making for hypertension (PHT) patients. A multicenter study 616 patients with PHT from three centers was stratified into five groups by their HVPG: < 12 (group A), ≤ 16 mmHg B), 20 C), 24 D), ≥ E). Concordance...
The social force model (SFM) is able to reproduce many crowd phenomena and laws based on Newtonian mechanics. However, the interaction forces used in depend relative geometric positions of pedestrians, ignoring impact velocity a dynamic crowd, which causes unrealistic simulation. This paper proposes novel method make pedestrians behave more realistically using perception. modified analyzes personal space, considers impacts velocities introduces better prediction interactions information not...
Background The hospital environment, particularly the intensive care unit (ICU), contributes to transmission of several nosocomial pathogens, which can survive in this setting for a longer period time and, turn, contaminate surfaces or medical tools. Thus, appropriate disinfection these areas and devices are crucial controlling preventing further infection. In study, we examined effect different concentrations chlorine-containing disinfectants (500mg/L, 1000mg/L, 2000mg/L) on ICU...
Objective To study the effect of antiviral therapy during pregnancy on frequency natural killer (NK) cells in peripheral blood women with HBV DNA positive chronic hepatitis B (CHB). Method In total 124 female subjects were divided into four groups: 11 healthy non-pregnant (Normal group), 26 immune tolerance period virus (HBV) infection (CHB 41 pregnant CHB without treatment (Untreated and 46 receiving (Treated group). The NK detected by flow cytometry. Result [15.30 (12.80, 18.40)] was...
Abstract Liver disease is an important that seriously threatens human health. It accounts for the highest proportion in various malignant tumors, and its incidence rate mortality are on rise, affecting Modern imaging has developed rapidly, but application of image segmentation liver tumor surgery still rare. The processing technology represented by artificial intelligence (AI) can greatly improve efficiency surgery, reduce surgical complications, cost surgery. Hepatocellular carcinoma most...
Objective: To investigate the curative effect of antiviral therapy and related factors influencing affect in children with immune-tolerant phase chronic hepatitis B. Methods: From May 2014 to April 2015, 46 B, aged 1 16 years were enrolled as treatment group. All cases treated group either received interferon alpha (3-5 MIU/m(2), once daily) lamivudine combination (if HBV DNA decreased < 2 log(10)) or repeatedly interferon-alpha alone >2 for 12 weeks. Interferon was discontinued at 72 weeks...
In big data analysis with the rapid improvement of computer storage capacity and development complex algorithms, exponential growth massive has also made science technology progress each passing day. Based on omics such as mRNA data, microRNA or DNA methylation this study uses traditional clustering methods kmeans, K-nearest neighbors, hierarchical clustering, affinity propagation, nonnegative matrix decomposition to classify samples into categories, obtained: (1) The assumption that...
Objective To explore the correlation between postpartum hepatitis and changes of plasmacytoid dendritic cells’ (pDC) function frequency in B e antigen (HBeAg)-positive pregnant women with chronic virus (HBV) infection. Methods Pregnant HBV infection receiving antiviral treatment (treated group) or not (untreated were enrolled demographic information was collected before delivery. Clinical biochemical, virological serology, pDC functional molecular expression tested delivery at 6, 12, 24...
<title>Abstract</title> <bold>Aim:</bold> To evaluate the differences in agreement between wedged hepatic venous pressure (WHVP) and portal (PVP) at different gradient (HVPG) levels to provide new guidance for clinical diagnosis management of hypertension (PHT). <bold>Methods:</bold> A multicenter study 785 patients with PHT from three centers was stratified into five groups by their HVPG: <12 (group A), 12 ≤ HVPG < 16 mmHg B), 20 C), 24 D), ≥24 E). Concordance analyzed using Pearson’s...
Background: Chronic hepatitis B (CHB) in children presents a significant global health challenge, with liver inflammation and fibrosis being critical concerns for disease progression long-term outcomes. Methods: This retrospective study analyzed 1629 pediatric CHB patients from the Fifth Medical Center of Chinese PLA General Hospital, spanning January 2000 to December 2021. Liver biopsies were performed assess severity fibrosis, which graded using Scheuer scoring system. Key clinical...
Genetic factors underlie a substantial proportion of paediatric liver diseases. Hereditary diseases have considerable genetic heterogeneity and variable clinical manifestations, which bring great challenges to molecular diagnoses. In this study, we investigated group patients with varying degrees dysfunction using hierarchical testing strategy.We first applied panel encompassing 166 known causal genes disease. We then used exome sequencing (ES) in those whose cases remained undiagnosed...
The number of studies describing the use metformin in gestational diabetes mellitus (GDM) is increasing, and considered an acceptable economic alternative to insulin many countries. Because can pass through placenta, it necessary continuously assess maternal fetal impact compared with pregnancy.