A5101566422- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Circular RNAs in diseases
- Forensic Entomology and Diptera Studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Infectious Diseases and Mycology
- Tryptophan and brain disorders
- SARS-CoV-2 detection and testing
- Nonmelanoma Skin Cancer Studies
- Gut microbiota and health
- Immune Cell Function and Interaction
- Immune cells in cancer
- Wound Healing and Treatments
- Cutaneous Melanoma Detection and Management
- Heavy metals in environment
- Heavy Metal Exposure and Toxicity
Sun Yat-sen University
2021-2025
Kunming Medical University
2025
Peking University
2020-2025
First Affiliated Hospital of Kunming Medical University
2025
Peking University Third Hospital
2024
East China Normal University
2024
Guangzhou Chest Hospital
2016-2023
Beijing University of Chinese Medicine
2017-2023
Southwest Jiaotong University
2022
Xidian University
2021-2022
Abstract Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb bowel disease (IBD). Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress (ECN-pE) for treatment To improve bioavailability ECN-pE gastrointestinal tract, chitosan sodium alginate, effective biofilms, were used coat via...
Tuberculosis (TB) remains a serious global public health problem in the present. TB also affects other sites (extrapulmonary tuberculosis, EPTB), and accounts for significant proportion of tuberculosis cases worldwide. In order to comprehensively understand epidemiology EBTB China, improve early diagnosis treatment, we conducted large-scale multi-center observational study assess demographic data prevalence common EPTB inpatients, further evaluate concurrent with Pulmonary (PTB) associations...
Abstract Buruli ulcer (BU) is an emerging infectious disease that causes disfiguring skin ulcers. The causative agent, Mycobacterium ulcerans , secretes toxin called mycolactone triggers inflammation and immunopathology. Existing treatments are lengthy consist of drugs developed for tuberculosis. Here, we report a pyrazolo[1,5-a]pyridine-3-carboxamide, TB47, highly bactericidal against M. both in vitro vivo. In the validated mouse model BU, TB47 alone reduces burden footpads by more than 2.5...
Abstract Background Bivalent genes, of which promoters are marked by both H3K4me3 (trimethylation histone H3 on lysine 4) and H3K27me3 27), play critical roles in development tumorigenesis. Monomethylation 4 (H3K4me1) is commonly associated with enhancers, but H3K4me1 also present at promoter regions as an active bimodal or a repressed unimodal pattern. Whether the co-occurrence bivalent marks plays regulatory role largely unknown. Results We report that process lineage differentiation,...
AimsA high proportion of all patients with tuberculosis (TB) present extrapulmonary TB (EPTB), including concurrent EPTB involving more than one lesion site. However, previous reports only characterized lesions single-site cases. This study aimed to investigate epidemiological characteristics and association rules cases in China.MethodsAn observational multi-centre 208,214 was undertaken China from January 2011 December 2017. Multi-variable logistic regression analysis used identify...
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent of keratinocyte-derived malignancies with actinic keratosis (AK) as a precancerous lesion. To comprehensively delineate underlying mechanisms for whole progression from normal skin to AK invasive cSCC, we performed single-cell RNA sequencing (scRNA-seq) acquire transcriptomes 138,982 cells 13 samples six patients including AK, in situ (SCCIS), and their matched tissues, covering comprehensive clinical courses cSCC. We...
Tiansi Liquid is a traditional Chinese herbal medicine used to treat depression; however, the underlying mechanisms remain unclear. Here, we examined effect of in rat model hydrocortisone-induced depression using behavioral testing, 16S rRNA high-throughput pyrosequencing and high-performance liquid chromatography-mass spectrometry-based metabolomics tryptophan (TRP)⁻kynurenine (KYN) pathway. significantly improved sucrose preference exploratory behavior depressive rats. The richness...
MicroRNAs (miRNAs) can function as oncogenes or tumor suppressor genes and are involved in multiple processes cancer development progression. For example, miR-192 is dysregulated human cancers, including osteosarcoma (OS). However, the pathophysiological role of its relevance to OS cell growth invasion has not yet been clarified. This study aimed investigate expression elucidate molecular mechanisms by which acts a this disease. The qRT-PCR data identified significant down-regulation 20...
Abstract To determine what exacerbate severity of the COVID-19 among patients without comorbidities and advanced age investigate potential clinical indicators for early surveillance, we adopted a nested case−control study, design in which severe cases (case group, n = 67) moderate (control diagnosed with comorbidities, ages ranging from 18 to 50 years who admitted Wuhan Tongji Hospital were matched based on age, sex BMI. Demographic characteristics, risk factors associated symptoms analysed....
Abstract Background World Health Organization recommends countries introducing new drug and short treatment regimen for resistant tuberculosis (DR-TB) should develop implement a system active pharmacovigilance that allows detection, reporting management of adverse events. The aim the study is to evaluate frequency severity events (AEs) bedaquiline-containing in cohort Chinese patients with multidrug-resistant (MDR)/extensively drug-resistant (XDR)-TB based on safety monitoring (aDSM) New...
Objective: This study aimed to investigate the optimization of expanded flaps for repair large facial defects, while also providing insights and strategies prevention management complications. Methods: A retrospective was conducted with 5 patients who underwent skin soft tissue defects head face flap at First Affiliated Hospital Kunming Medical University between October 2018 May 2021. Patient data were collected, including age, diagnosis, lesion area, photographs, together details type,...
Background: Extrapulmonary tuberculosis (EPTB) is a significant health problem which can lead to severe morbidity and mortality. In clinical practice, EPTB have variety of nonspecific manifestations be concurrent with other types EPTB. As information pertaining scarce, research efforts are needed find explore the association networks rules Materials Methods: An observational multicenter study was carried out at 21 hospitals from 15 provinces in China Jan 1, 2011, Dec 31, 2017. All adult...
Abstract With the rapid advancements in autonomous driving, pure vision-based solutions have garnered significant attention. However, existing vision sensors are limited by their specific spectral operating ranges and complexity of processing hybrid optical/electrical signals. In this study, we present a fully circuit-emulated system that employs fusion solution for integrating image sensing, fusion, edge extraction, decision-making functionalities. This utilizes featuring...