A5100411098- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Esophageal Cancer Research and Treatment
- Diabetes Management and Research
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Tuberculosis Research and Epidemiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infectious Diseases and Tuberculosis
- Urinary Bladder and Prostate Research
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Pelvic floor disorders treatments
- Ear and Head Tumors
- Cancer Immunotherapy and Biomarkers
- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Peptidase Inhibition and Analysis
- Ion Transport and Channel Regulation
- Iron Metabolism and Disorders
- Breast Lesions and Carcinomas
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Southern Medical University Shenzhen Hospital
2021-2025
Southern Medical University
2025
Nanjing Drum Tower Hospital
2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2024
Chongqing Medical University
2022-2024
Tongde Hospital of Zhejiang Province
2023-2024
The role of defective glucose transport in the pathogenesis noninsulin-dependent diabetes (NIDDM) was examined Zucker diabetic fatty rats, a model NIDDM. As human NIDDM, insulin secretion unresponsive to 20 mM glucose. Uptake 3- O -methylglucose by islet cells less than 19% controls. β cell transporter (GLUT-2) immunoreactivity and amount GLUT-2 messenger RNA were profoundly reduced. Whenever fewer 60% GLUT-2-positive, response absent hyperglycemia exceeded 11 plasma We conclude that NIDDM...
Cardiac progenitor cells are an attractive cell type for tissue regeneration, but their mechanism myocardial remodeling is still unclear.This investigation determines how chronological age influences the phenotypic characteristics and secretome of human cardiac (CPCs), potential to recover injured myocardium.Adult (aCPCs) neonatal (nCPCs) were derived from patients aged >40 years or <1 month, respectively, functional was determined in a rodent infarction model. A more robust vitro...
AimsA high proportion of all patients with tuberculosis (TB) present extrapulmonary TB (EPTB), including concurrent EPTB involving more than one lesion site. However, previous reports only characterized lesions single-site cases. This study aimed to investigate epidemiological characteristics and association rules cases in China.MethodsAn observational multi-centre 208,214 was undertaken China from January 2011 December 2017. Multi-variable logistic regression analysis used identify...
GLUT2 underexpression has been reported in the +-cells of Zucker diabetic fatty rats and db/db mice, models spontaneously occurring NIDDM with antecedent obesity. To determine whether a nonobese rodent model exhibit same abnormalities GLUT2, we studied Goto-Kakizaki rats. In these mildly animals glucose-stimulated insulin secretion was reduced at all ages examined from 8 to 48 wk. normal control Wistar rats, immunostainable present on insulin-positive cells pancreatic islets. Only 85% were...
A cDNA termed reg was recently isolated by differential screening of a library prepared from regenerating islets pancreatic remnants rats subjected to 90% pancreatectomy and nicotinamide treatment. This led speculation that this gene may be involved in expansion β-cell mass. In the current study we have measured expression after implantation resection solid insulinoma tumor into rats, manuevers known, respectively, reduce reexpand volume β-cells islet. Animals with an implanted became...
Malnutrition is associated with adverse outcomes in patients diabetic kidney disease (DKD). However, it uncertain which nutritional assessment tools are most effective predicting the of DKD. This retrospective study was conducted at a single center and included 367 diagnosed DKD based on biopsy results between August 2009 December 2018. Four indices, namely Prognostic Nutritional Index (PNI), Geriatric Risk (GNRI), Triglycerides (TG) × Total Cholesterol (TC) Body Weight (BW) (TCBI),...
Background Diabetic bladder dysfunction (DBD) is a common urinary complication in diabetic patients, significantly affecting their overall well-being and quality of life, placing considerable burden on healthcare resources. Early prevention crucial; however, the absence simple effective tool to predict DBD onset remains significant challenge. This study aims identify risk factors for patients with type 2 diabetes mellitus (T2DM) develop predictive nomogram clinical application. Methods...
Langerhans cell histiocytosis (LCH) is a rare disease, most prevalent in children. Ultrasound noninvasive, cheap, and widely available technique. However, systematic elucidation of sonographic features LCH treatment related follow-up are relatively few, resulting overall underestimation the clinical value ultrasound diagnosing monitoring LCH. This study aimed to observe Cell Histiocytosis comparing with other imaging examinations, evaluate changes ultrasonography Forty-four children...
To investigate the clinical features, complications, diagnosis and management of congenital hepatic hemangiomas(CHHs). 12 neonates CHH admitted to our hospital in past 10 years were retrospectively analyzed, manifestations, auxiliary examination results, treatment methods, efficacy andprognosis reviewed. In this study, with CHHs reported. Among them, 8 cases underwent surgical recovered well postoperatively. 3 received routine pharmacological treatment, gradually recovering. Only one case,...
Arterial old-long-segment thrombus is a difficult-to-handle complication in brachio-cephalic fistula, leading to totally chronic occlusion, fistula dysfunction, and potential upper limb ischemia. This case study presented the successful clinical experience of using Fogarty adherent clot catheter remove an (15 cm) brachial artery, which was guided by ultrasound. The procedure resulted long-term patency arteriovenous with no early or delayed complications. highlighted effectiveness, safety,...
Abstract To identify the factors associated with serum total bilirubin (STB) and determine whether STB is independently diabetic retinopathy (DR) or kidney disease (DKD), 1,665 Chinese patients type 2 diabetes (T2DM) (248 outpatients newly diagnosed T2DM [NDM] 1,417 inpatients previously [PDM]) were studied. Clinical biochemical information was collected, a single nucleotide polymorphism (rs6704078) of UGT1A1 gene genotyped in 1,059 individuals. Multiple linear regression showed that...
BACKGROUND Endoscopic submucosal dissection (ESD) is a standardized therapeutic approach for early carcinoma of the digestive tracts. In this regard, process histopathological diagnosis requires standardization. However, uneven development healthcare in China, especially eastern and western creates challenges sharing diagnostic process. AIM To optimize ESD specimen sampling, embedding slide production, to provide complete accurate pathological reports. METHODS We established practical...
Background: Extrapulmonary tuberculosis (EPTB) is a significant health problem which can lead to severe morbidity and mortality. In clinical practice, EPTB have variety of nonspecific manifestations be concurrent with other types EPTB. As information pertaining scarce, research efforts are needed find explore the association networks rules Materials Methods: An observational multicenter study was carried out at 21 hospitals from 15 provinces in China Jan 1, 2011, Dec 31, 2017. All adult...
<h3>Importance</h3> A significant proportion of very preterm infants (<32 weeks' gestation) are discharged against medical advice (DAMA) from neonatal intensive care units in China. There is minimal information available on the potential outcomes providing complete before discharge these infants. <h3>Objective</h3> To describe DAMA if they receive based estimates derived a group propensity score–matched who not DAMA. <h3>Design, Setting, and Participants</h3> This cohort study enrolled...
To investigate the predictive value of systemic immune-inflammation-index (SII) and Pan-Immune-Inflammation-value (PIV) for axillary lymph node (ALN) metastasis in patients with breast cancer.We retrospectively collected data 247 invasive from Affiliated Hospital Jiangnan University. The state was confirmed by pathological diagnosis. Clinicopathological (age, ER, PR, HER2, Ki67 expression levels, diapause status, weight, histological grade, vascular invasion, node) were compared between...
Amylin is a 37-amino acid peptide synthesized in the pancreatic beta-cell and cosecreted with insulin. In situ hybridization of nondiabetic rat pancreas shows that insulin amylin RNA are both localized within islet Langerhans similar distribution. After 12 days insulin-induced hypoglycemia (mean blood glucose 3.0 +/- 0.4 mM [54 8 mg/dl]), fell greater than 95%. However, maintenance euglycemia by simultaneous infusion did not suppress or RNA. Fasting suppressed secretion from isolated,...
The urinary C-peptide/creatinine ratio (UCPCR) is low in patients with type 1 diabetes mellitus, but it has not been well characterized 2 mellitus (T2DM). We aimed to measure the UCPCRs T2DM and explore relationships among UCPCR, insulin resistance (IR), chronic vascular complications of diabetes.A cross-sectional study was performed 1299 Chinese hospitalized T2DM. Binary logistic regression used evaluate between UCPCR. K-means analysis allocate participants subgroups five six variables (age...
BACKGROUNDThe first line treatment regimen for esophageal cancer is still surgical resection and the choice of scheme depends on surgeon.Now efficacy comparison hybrid minimally invasive esophagectomy (HMIE) open (OE) controversial. AIMTo compare perioperative postoperative outcomes HMIE OE in patients with cancer. METHODSPubMed, EMBASE, Cochrane Library databases were searched related articles.The odds ratio (OR) or standard mean difference (SMD) a 95% confidence interval (CI) was used to...