A5100442315- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Acute Ischemic Stroke Management
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Diabetes Management and Research
- Neonatal and fetal brain pathology
- Drug Transport and Resistance Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Diet, Metabolism, and Disease
- Genetics and Neurodevelopmental Disorders
- Stroke Rehabilitation and Recovery
- Metabolism and Genetic Disorders
- Anesthesia and Neurotoxicity Research
- Digital Media and Visual Art
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Surgical site infection prevention
- Molecular Sensors and Ion Detection
- Lipid metabolism and disorders
- Sirtuins and Resveratrol in Medicine
Hebei Medical University
2012-2025
Second Hospital of Hebei Medical University
2010-2025
First Affiliated Hospital of Dalian Medical University
2024
Dalian Medical University
2024
Anqing City Hospital
2023
Nanjing Medical University
2023
Baoding People's Hospital
2023
Creative Commons
2023
Yang Hospital
2023
Capital Medical University
2023
Nuclear factor E2-related 2 (Nrf2) is a cap-n-collar basic leucine zipper (CNC-bZIP) transcription that well established as master regulator of phase II detoxification and antioxidant gene expression strongly expressed in tissues involved xenobiotic metabolism including liver kidney. Nrf2 also abundantly adipose tissue; however, the exact function adipocyte biology unclear. In current study we show targeted knock-out mice decreases tissue mass, promotes formation small adipocytes, protects...
The umbilical cord is a vital pathway for the fetus, which can bring oxygen/nutrition and take away waste products to maintain normal growth. Clinical studies found that abnormal coiling nuchal conditions of may be associated with fetal growth restriction. Although hemodynamic environment due morphology suspected account growth, specific influence on hemodynamics remains not fully understood. In this context, study aims investigate effects variation index (UCI) in order better address issue....
Among patients with chronic epilepsy, 70‑80% have cognitive impairment. To investigate the relationship between adiponectin (ADPN) and level in epilepsy its mechanism, 20 epileptic healthy controls were included for assessment of level. An ELISA was used to evaluate serum ADPN rat model established treated AdipoRon, an receptor (AdipoR) agonist, which binds AdipoR1 AdipoR2. The Morris water maze test assess function rats, expression levels synapsis‑associated proteins postsynaptic density...
Lamotrigine (LTG) is a broad-spectrum antiepileptic drug that widely used in clinic. However, the effect of LTG on cognition and neurodegeneration during epilepsy treatment remains controversial. In this study, we compared cognitive effects sodium valproate pentylenetetrazole (PTZ)-kindled animal model, dose dependency was tested for LTG.PTZ-kindled animals were divided into following groups: control group, treated with 3.5 mL/kg 0.9% chloride; low-dose 12.5 mg/kg LTG; middle-dose 25...
<h3>Importance</h3> A significant proportion of very preterm infants (<32 weeks' gestation) are discharged against medical advice (DAMA) from neonatal intensive care units in China. There is minimal information available on the potential outcomes providing complete before discharge these infants. <h3>Objective</h3> To describe DAMA if they receive based estimates derived a group propensity score–matched who not DAMA. <h3>Design, Setting, and Participants</h3> This cohort study enrolled...
Abstract A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unclear whether a causal role in humans. To investigate this potential relationship, Mendelian randomisation study was conducted using International League Against Epilepsy data as the discovery set FinnGen replication set. It discovered three antidiabetic drug target genes,...
The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammatory pathway is implicated in the development of epilepsy and can be suppressed by activation silent information regulator 1 (SIRT1). However, expression correlation NLRP3 SIRT1 drug-resistant (DRE) remain unknown. This study evaluated histopathology cerebral cortex from nine patients with DRE eight cavernous haemangioma undergoing surgical treatment. It analysed NLRP3, interleukin-1β (IL-1β), caspase-1 using...
Bronchial artery aneurysm (BAA) is an uncommon disease, and spontaneous rupture of ectopic BAA can be difficult for diagnosis life-threatening. This case study describes a 52-year-old man who presented with acute onset right chest pain, mild tachycardia, hypertension. The initial myocardial infarction was made, the patient given nitroglycerin prior to admission our hospital. However, patient's symptoms deteriorated. An enhanced computed tomography scan revealed ruptured 25-mm diameter...
Background: To explore the risk factors for hypoglycemia in patients with type 2 diabetes mellitus (T2DM) after intensive insulin therapy and blood glucose monitoring strategy.
 Methods: A total of 172 T2DM diagnosed from March 2019 to 2021 were randomly divided into training (n=115) test sets (n=57), given therapy. After treatment, set was (n=35) non-hypoglycemia groups (n=80). Univariate multivariate logistic regression analyses performed. Then 120 instantaneous scanning system...
The objective of this study was to develop and validate a predictive model for the risk poor neurological status in in-hospital patients with acute ischemic stroke (AIS) after intravenous thrombolysis.This 2-center retrospective included AIS treated at Advanced Stroke Center Second Hospital Hebei Medical University Baoding No.1 Central between January 2018 2020). function day 7 onset used as endpoint study, which evaluated using National Institute Health Scale (NIHSS) score.A total 878 were...
Background and objective Psychological insulin resistance (PIR), which refers to the reluctance of diabetic patients use insulin, is a frequently encountered clinical issue. Needle-free injection (NFI) offers advantages in terms expediting absorption mitigating adverse reactions related injection. To evaluate effects subcutaneous aspart 30 with NFI on PIR dosage type 2 diabetes mellitus (T2DM). Methods Sixty-four T2DM participated this randomized, prospective, open, crossover study. Insulin...