A5111208212- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Sinusitis and nasal conditions
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Diabetes Management and Research
- Chronic Myeloid Leukemia Treatments
- Reproductive tract infections research
- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Liver Disease and Transplantation
- Gastrointestinal motility and disorders
- Heavy Metal Exposure and Toxicity
- Cancer Research and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Antifungal resistance and susceptibility
- Acute Lymphoblastic Leukemia research
- interferon and immune responses
- Receptor Mechanisms and Signaling
- IL-33, ST2, and ILC Pathways
- Polydiacetylene-based materials and applications
- Gestational Trophoblastic Disease Studies
- Gastroesophageal reflux and treatments
University of Chicago
2024-2025
Henan Cancer Hospital
2024
Zhengzhou University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Fudan University
2024
First Affiliated Hospital of Dalian Medical University
2024
Dalian Medical University
2024
Guangxi Medical University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2015
Harbin Medical University
2014
Bacterial outer membrane vesicles (OMVs) are promising as antitumour agents, but their clinical application is limited by toxicity concerns and unclear mechanisms. We engineered OMVs with cadherin 17 (CDH17) tumour-targeting nanobodies, enhancing tumour selectivity efficacy while reducing adverse effects. These function natural stimulator of interferon genes (STING) agonists, activating the cyclic GMP-AMP synthase (cGAS)-STING pathway in cancer cells tumour-associated macrophages (TAMs)....
Dlx3, a homeodomain transcription factor, is essential for placental development in the mouse. The Dlx3−/− mouse embryo dies at embryonic d 9.5–10 putatively due to failure. To develop more comprehensive understanding of gene profile regulated by microarray analysis was used determine differences expression within placenta Dlx3+/+ and mice. Array revealed differential 401 genes, 33 genes which signal log ratio values null/wild-type were lower than −0.5 or higher 0.5. corroborate these...
Abstract Background This study evaluated the efficacy and safety of low‐dose anlotinib combined with immune checkpoint inhibitors as second‐line or later treatment for extensive‐stage small cell lung cancer (ES‐SCLC). Methods The included 42 patients ES‐SCLC who were treated programmed death protein 1/programmed death‐ligand 1 at Henan Cancer Hospital between March 2019 August 2022. We retrospectively analyzed data these patients. Indicators assessed progression‐free survival (PFS), overall...
Background and objective Psychological insulin resistance (PIR), which refers to the reluctance of diabetic patients use insulin, is a frequently encountered clinical issue. Needle-free injection (NFI) offers advantages in terms expediting absorption mitigating adverse reactions related injection. To evaluate effects subcutaneous aspart 30 with NFI on PIR dosage type 2 diabetes mellitus (T2DM). Methods Sixty-four T2DM participated this randomized, prospective, open, crossover study. Insulin...
Background: Neutrophils are major effector cells in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the functional status and pathogenic role of neutrophils remain unclear.To perform an integrated transcriptome analysis human CRSwNP at single-cell level to assess activation heterogeneity polyp-infiltrating under different inflammatory conditions.Methods: We used RNA sequencing (scRNA-sequencing) data polyp tissues from 10 eosinophilic (eCRSwNP) 7 noneosinophilic (neCRSwNP)...
Patients with choriocarcinoma (CC) accompanying chemoresistance conventionally present a poor prognosis. Whether ras protein activator like-1 (RASAL1) functions as tumor promoter or suppressor depends on types. However, the role of RASAL1 in process CC and underlying molecular mechanism remain elusive.
Abstract Disclosure: N. Shukla: None. C. Ju: H. Li: He: R. Kulkarni: Advisory Board Member; Self; Novo Nordisk, Biomea Fusion Inc, REDD Pharma. Grant Recipient; Inversago. Chromatin-associated regulatory RNAs (carRNA), which include promoter- and enhancer-associated as well several non-coding repeat elements have been established in the literature important regulators of global gene transcription. However, regulation carRNAs themselves has an enigma. Recent publications from He Lab at...
Abstract Chlamydia trachomatis (Ct) infection can induce host cells to produce numerous cytokines. Cytokines play important roles in inflammatory response. Although inflammation protect the body, persistent lead pathological changes and tissue damages. Further research should determine whether cytokine production directly affects development outcomes of inflammation. This study summarizes Ct related