A5100431923- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Lipid metabolism and disorders
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Pharmacological Effects of Natural Compounds
- Liver Diseases and Immunity
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Hedgehog Signaling Pathway Studies
- Machine Learning in Bioinformatics
- MRI in cancer diagnosis
- Sirtuins and Resveratrol in Medicine
- Additive Manufacturing and 3D Printing Technologies
- Growth Hormone and Insulin-like Growth Factors
- Endoplasmic Reticulum Stress and Disease
- Gene expression and cancer classification
Peking University People's Hospital
2021-2025
Peking University
2021-2025
Beihua University
2025
Chinese People's Armed Police Force
2024
Liaoning University
2014-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
Chinese People's Armed Police General Hospital
2024
Shanghai University of Traditional Chinese Medicine
2019-2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023
Shuguang Hospital
2019-2023
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of chronic ranging from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH). However, the molecular mechanisms NASH progression remain incompletely understood. White adipose tissue (WAT) has emerged as an important endocrine organ and contributes not only initial stage NAFLD, but also its severity. In current study, through transcriptomic analysis we identified increased expression Sparcl1, secreted glycoprotein, in...
Triply periodic minimal surfaces (TPMS) structures have been extensively promoted for mimicking the tissue scaffolds with interconnected pores and robust mechanical properties. To further optimize performance, two kinds of TPMS including Schwarz P (P) Gyroid (G) uniform different graded-thickness were designed proposed in current work. Biodegradable polymer composites based on poly (butyleneadipate-co-terephthalate) (PBAT) (lactic acid) (PLA) developed into fused filament fabrication (FFF)...
Abstract Collider-stratification bias arises from conditioning on a variable (collider) which opens path exposure to outcome. M occurs when the collider-stratification is transmitted through ancestors of and Previous theoretical work, but not empirical data, has demonstrated that smaller than confounding bias. The authors simulated data for large cohort studies with binary exposure, an outcome, collider, 2 predictors collider. They created 178 scenarios by changing frequencies variables...
The chemical structure and pharmacological activity of Polygonatum cyrtonema Hua polysaccharides have garnered significant attention in recent years. In this study, a homogeneous polysaccharide, PCP1, was extracted from P. rhizomes purified. Monosaccharide composition analysis showed that PCP1 is primarily composed fructose, glucose, mannose. Chemical the main chain mainly →1)-β-D-Fruf-(2→ →1,6)-β-D-Fruf-(2→, with small amounts →6)-α-D-Glcp-(1→, →4)-β-D-Manp-(1→, β-D-Glcp-(1→. side...
Objective Multiple observational studies have demonstrated an association between type 2 diabetes mellitus (T2DM) and chronic liver diseases (CLDs). However, the causality of T2DM on CLDs remained unknown in various ethnic groups. Methods We obtained instrumental variables for conducted a two-sample mendelian randomization (MR) study to examine causal effect nonalcoholic fatty disease (NAFLD), hepatocellular carcinoma (HCC), viral hepatitis, hepatitis B virus (HBV) infection, C (HCV)...
The unripe fruits of Rubus chingii Hu. ("Fu-peng-zi" in Chinese) is a well-known herbal tonic traditional Chinese medicine (TCM) for tonifying liver and kidney. However, little known regarding its therapeutic efficacy against fibrosis the underlying mechanism.The current research aims to explore potential extract (RF) treatment mechanism. RF was administered (450 900 mg·kg- 1 body weight per day) orally male C57BL/6 mice with CCl4-induced 3 weeks. histopathological changes stage tissue were...
Non‑alcoholic fatty liver disease (NAFLD) is the consequence of insulin resistance, acid accumulation, oxidative stress and lipotoxicity. The present study aimed to elucidate effect Quaking 5 (QKI 5) as mediated by Sirtuin 1 (SIRT1) on triglyceride (TG) synthesis in an NAFLD mouse model. A high‑fat diet‑induced model was established mice, hepatocytes were isolated characterize effects QKI SIRT1 TG liver. Body weight wet recorded. In addition, serum levels total cholesterol, TG, alanine...
The prevalence of early-onset type 2 diabetes (EOD) is rapidly increasing. This study intends to screen for early cardiovascular abnormalities in patients newly diagnosed with EOD and evaluate the risk across cluster phenotypes. A total 400 ≤ 40 years old were enrolled from START cohort (the Study diAgnosed eaRly onset diabeTes). Cluster classification was performed using K-means method based on age, BMI, HbA1c, HOMA2-β, HOMA2-IR, GAD antibodies. Echocardiography carotid ultrasound within 3...
To identify alterations of specific gene expression, immune infiltration components, and potential biomarkers in liver ischemia-reperfusion injury (IRI) following transplantation (LT).GSE23649 GSE151648 datasets were obtained from the Gene Expression Omnibus (GEO) database. determine differentially expressed genes (DEGs), we utilized R package "limma". We also different cells through single-sample gene-set enrichment analysis (ssGSEA). Furthermore, LASSO logistic regression to select feature...
Women with polycystic ovarian syndrome (PCOS) are more likely to have non-alcoholic fatty liver disease (NAFLD) than non-PCOS women; however, the exact mechanism underlying this trend is unknown. The receptor activator of NF-κB ligand (RANKL) strongly involved in bone metabolism and has multiple functions. Recent studies suggest that RANKL implicated hepatic insulin resistance (IR), which highest risk factor for NAFLD. This study aimed assess role NAFLD Chinese women PCOS. A cross-sectional...
Evaluation of the degree liver fibrosis is an important basis for clinical diagnosis and treatment patients with hepatocellular carcinoma (HCC). It meaningful to make a preoperative evaluation non-invasive methods. In current study, 12 commonly used serological indicators from 161 HCC different were collected retrospectively, 8 (ALB, PA, TBil, INR, AST, GGT, ALP, PT) ultimately in matter-element analysis create formula. The relationship between those results histological sub-classification...
The urinary C-peptide/creatinine ratio (UCPCR) is low in patients with type 1 diabetes mellitus, but it has not been well characterized 2 mellitus (T2DM). We aimed to measure the UCPCRs T2DM and explore relationships among UCPCR, insulin resistance (IR), chronic vascular complications of diabetes.A cross-sectional study was performed 1299 Chinese hospitalized T2DM. Binary logistic regression used evaluate between UCPCR. K-means analysis allocate participants subgroups five six variables (age...
Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in acids levels serum and improvement fat content caused by exercise intervention individuals nonalcoholic disease. The exploratory study included 208 central obesity from an randomized clinical trial for participants were randomly assigned control, moderate, vigorous-moderate groups 12 months. Changes total acids, leucine,...
Backgroud and aims: Ductular reaction (DR) is a common pathological change thought to have key role in the pathogenesis progression of liver fibrosis. Our previous study reported Gypenosides (GPs) ameliorated fibrosis, however, anti-fibrotic mechanisms GPs are still unclear. Methods: Liver fibrosis was induced rats by carbon tetrachloride combining with 2-acerylaminofluorene (CCl 4 /2-AAF), Mdr2 knockout ( −/− ) mice evaluate GPs. In vitro , WB-F344 cells, hepatic progenitor cells (HPCs)...
Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of metabolic steatotic liver disease (MASLD), and closely associated with a high risk liver-related morbidity mortality. Although enhanced neutrophil infiltration histological hallmark MASH, morphological pattern hepatic neutrophils their relevance to definition MASH remain unknown. This clinicopathological study aimed determine association neutrophilic crown-like structures (CLSs) in biopsies evaluate diagnosis...