A5005929167- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- DNA Repair Mechanisms
- Advanced Wireless Communication Techniques
- Wireless Communication Networks Research
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Renal and related cancers
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- PAPR reduction in OFDM
- MicroRNA in disease regulation
- Blind Source Separation Techniques
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Carcinogens and Genotoxicity Assessment
- Wireless Signal Modulation Classification
- Prenatal Screening and Diagnostics
- Photosynthetic Processes and Mechanisms
- Cavitation Phenomena in Pumps
- Cancer-related molecular mechanisms research
- Genetic and Kidney Cyst Diseases
University of Science and Technology of China
2016-2025
Soochow University
2025
Center for Excellence in Molecular Cell Science
2016-2024
Westlake University
2024
Fudan University
2015-2024
Yangzhou University
2024
Hefei National Center for Physical Sciences at Nanoscale
2011-2023
Shandong Agricultural University
2012-2023
Xuzhou Medical College
2023
Physical Sciences (United States)
2012-2022
Based on the second-order perturbation combining spin-orbit and nonadiabatic couplings, we derived an analytical formula for nonradiative decay rate between triplet singlet states by using thermal vibration correlation function (TVCF) approach. Origin displacement, distortion, Duschinsky rotation of potential energy surfaces are taken into accounts within multiple harmonic oscillator model. When coupled with first-principles calculation anthracene, theoretical phosphorescence spectrum is in...
Hexanucleotide repeat expansions in the C9orf72 gene are most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to lack trunk neuromuscular organoids (NMOs) from ALS patients' induced pluripotent stem cells (iPSCs), an organoid system was missing model spinal neurodegeneration. With patient-derived iPSCs isogenic controls, we used NMO containing cord neural peripheral muscular tissues show that NMOs could defects ALS, including contraction weakness,...
Background MicroRNAs (miRNAs) are the class of small endogenous RNAs that play an important regulatory role in cells by negatively affecting gene expression at transcriptional and post-transcriptional levels. There have been extensive studies aiming to discover miRNAs analyze their functions from a variety species. However, there no published miRNA profiles human testis using next generation sequencing (NGS) technology. Results We employed Solexa technology profile normal testis. Total 770...
Asthenozoospermia is a common cause of male infertility, but its etiology remains incompletely understood. We recruited three Pakistani infertile brothers, born to first-cousin parents, displaying idiopathic asthenozoospermia no ciliary-related symptoms. Whole-exome sequencing identified missense variant (c.G5408A, p.C1803Y) in DNAH17, functionally uncharacterized gene, recessively cosegregating with the family. specifically expressed testes, was localized sperm flagella, and mutation did...
Diethylhexyl phthalate (DEHP) is an estrogen‐like compound widely used as a commercial plasticizer and present in medical devices, tubing, food containers packaging. It considered endocrine disruptor studies on experimental animals showed that exposure to DEHP can alter the function of several organs including liver, kidneys, lungs reproductive system, particularly developing testes prenatal neonatal males. Exposure has been proposed potential human health hazard. This study assessed effects...
Fanconi anemia (FA) genes play important roles in spermatogenesis. In mice, disruption of Fancm impairs male fertility and testicular integrity, but whether FANCM pathogenic variants (PV) similarly affect men is unknown. Here we characterize a Pakistani family having three infertile brothers, two manifesting oligoasthenospermia one exhibiting azoospermia, born to first-cousin parents. A homozygous PV (c.1946_1958del, p.P648Lfs*16) was found cosegregating with infertility. Our objective...
Human infertility is a multifactorial disease that affects 8%–12% of reproductive-aged couples worldwide. However, the genetic causes human are still poorly understood. Synaptonemal complex (SC) conserved tripartite structure holds homologous chromosomes together and plays an indispensable role in meiotic progression. Here, we identified three homozygous mutations SC coding gene C14orf39/SIX6OS1 infertile individuals from different ethnic populations by whole-exome sequencing (WES). These...
Multiple morphological abnormalities of the sperm flagella (MMAF) are most severe form asthenozoospermia due to impaired axoneme structure in flagella. Dynein arms necessary components flagellar axoneme. In this study, we recruited 3 unrelated consanguineous Pakistani families with multiple MMAF-affected individuals, who had no overt ciliary symptoms. Whole-exome sequencing and Sanger identified 2 cilia associated protein 57 (CFAP57) loss-of-function mutations (c.2872C>T, p. R958*;...
Much recent attention has been focused on Aurora C, the third member of mammalian kinases family that plays significant roles in mitosis. We report here using sensitive RT‐PCR to amplify C‐terminal, we found C is not only expressed highly testis, but also among 16 other human tissues a broad‐spectrum way. as chromosomal passenger protein, co‐localized with B and Survivin mitotic cells. can be associated vivo directly binds vitro . Over‐expression catalytically inactive mutant impaired...
Primordial follicles, providing all the oocytes available to a female throughout her reproductive life, assemble in perinatal ovaries with individual surrounded by granulosa cells. In mammals including mouse, most die apoptosis during primordial follicle assembly, but factors that regulate oocyte death remain largely unknown. Proliferating cell nuclear antigen (PCNA), key regulator many essential cellular processes, was shown be differentially expressed these processes mouse using 2D-PAGE...
Next-generation sequencing has been widely applied to understand the complexity of non-coding RNAs (ncRNAs) in a cost-effective way. In this study, we developed mirTools 2.0, an updated version 1.0, which includes following new features. (1) From miRNA discovery 2.0 allows users detect and profile various types ncRNAs, such as miRNA, tRNA, snRNA, snoRNA, rRNA, piRNA. (2) profiling identify miRNA-targeted genes performs detailed functional annotation targets, including Gene Ontology, KEGG...
Most ovarian cancers originate from the surface epithelium and are characterized by aneuploid karyotypes. Aneuploidy, a consequence of chromosome instability, is an early event during development cancers. However, how cells evolved normal diploid in remains unknown. In present study, cytogenetic analyses mouse syngeneic cancer model revealed that epithelial (MOSECs) experienced intermediate tetraploid cell stage, before evolving to (mainly near-tetraploid) cells. Using long-term live-cell...
Automatic modulation recognition is advantageous for wireless communication systems employing adaptive modulation, software-defined radio, and cognitive radio. In this paper, we consider a phase based maximum likelihood (ML) approach identifying the format of linearly modulated signal. Since optimal ML scheme computationally intensive, propose two approximate alternatives, which can offer close-to-optimal performance with reduced complexity. We then present general analysis classification K...
Meiotic recombination permits exchange of genetic material between homologous chromosomes. The replication protein A (RPA) complex, the predominant ssDNA-binding is required for nearly all aspects DNA metabolism, but its role in mammalian meiotic remains unknown due to embryonic lethality RPA mutant mice. a heterotrimer RPA1, RPA2, and RPA3. We find that loss largest subunit, leads disappearance RPA2 RPA3, resulting absence complex. Using an inducible germline-specific inactivation strategy,...