A5101430947- Sperm and Testicular Function
- Multiple Myeloma Research and Treatments
- Reproductive Biology and Fertility
- Stress Responses and Cortisol
- Chromosomal and Genetic Variations
- Legume Nitrogen Fixing Symbiosis
- DNA Repair Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant-Microbe Interactions and Immunity
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Prenatal Screening and Diagnostics
- Tryptophan and brain disorders
- Renal and related cancers
- Epigenetics and DNA Methylation
- Pharmaceutical and Antibiotic Environmental Impacts
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Aquaculture disease management and microbiota
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
- Microbial Community Ecology and Physiology
- Immune cells in cancer
Beijing University of Chemical Technology
2023-2025
ZheJiang Academy of Agricultural Sciences
2025
Anhui Medical University
2022-2024
Ministry of Education of the People's Republic of China
2022-2024
University of Massachusetts Chan Medical School
2024
Nanjing Medical University
2013-2024
First Affiliated Hospital of Anhui Medical University
2022-2024
Jiangsu Province Hospital
2012-2024
Shanxi Medical University
2024
Northwest University
2015-2024
Abstract The axonemal dynein arms (outer (ODA) and inner (IDAs)) are multiprotein structures organized by light, intermediate, light intermediate (LIC), heavy chain proteins. They hydrolyze ATP to promote ciliary flagellar movement. Till now, a variety of protein deficiencies have been linked with asthenospermia (ASZ), highlighting the significance these in human sperm motility. Herein, we detected bi-allelic DNALI1 mutations [c.663_666del (p.Glu221fs)], an ASZ patient, which resulted...
Background The association between the TDRD6 variants and human infertility remains unclear, as only one homozygous missense variant of was found to be associated with oligoasthenoteratozoospermia (OAT). Methods Whole-exome sequencing Sanger were employed identify potential pathogenic in infertile men. Histology, immunofluorescence, immunoblotting ultrastructural analyses conducted clarify structural functional abnormalities sperm mutated patients. Tdrd6 -knockout mice generated using...
Meiotic recombination permits exchange of genetic material between homologous chromosomes. The replication protein A (RPA) complex, the predominant ssDNA-binding is required for nearly all aspects DNA metabolism, but its role in mammalian meiotic remains unknown due to embryonic lethality RPA mutant mice. a heterotrimer RPA1, RPA2, and RPA3. We find that loss largest subunit, leads disappearance RPA2 RPA3, resulting absence complex. Using an inducible germline-specific inactivation strategy,...
Abstract Breast cancer susceptibility gene II ( BRCA2 ) is central in homologous recombination (HR). In meiosis, binds to MEILB2 localize DNA double-strand breaks (DSBs). Here, we identify and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of by binding an α-helical N-terminus preventing self-association. the C-terminus MEILB2, resulting formation BRCA2-MEILB2-BRME1 ternary complex. Brme1 knockout −/− mice, BRCA2-MEILB2 complex destabilized, leading defects DSB repair,...
Abstract Lysine acetylation (Kac) is an important protein post‐translational modification in both eukaryotes and prokaryotes. Herein, we report the results of a global proteome analysis Kac its diverse functions rice ( Oryza sativa ). We identified 1353 sites 866 proteins seedlings. A total 11 motifs are conserved, 45% localized to chloroplast. Among all acetylated proteins, 38 combined core histones. Bioinformatics revealed that occurs on range involved wide variety biological processes,...
Patients with ulcerative colitis are at a very high risk of developing colorectal cancer. Corticotrophin-releasing hormone (CRH) family peptides and their receptors (CRHRs) found to modulate inflammation tumor cell growth. However, the role CRH in inflammation-related colon cancer is still unknown. The aim this study was investigate functions CRHR1 signaling on development colitis-associated (CAC). Crhr1 -deficient ( −/− ) mice were used explore azoxymethane (AOM) dextran sodium sulfate...
Meiotic recombination enables reciprocal exchange of genetic information between parental chromosomes and is essential for fertility. MEIOB, a meiosis-specific ssDNA-binding protein, regulates early meiotic recombination. Here we report that the human infertility-associated missense mutation (N64I) in MEIOB causes protein degradation reduced crossover formation mouse testes. Although N64I substitution associated with infertility, point mutant mice are fertile despite defects. Meiob...
Antibiotic growth promoters have been banned in animal husbandry and aquaculture China, since 2020. Florfenicol (FLO) is the most used antibiotics for controlling various bacterial disease fish, although its effect on health of farmed fish remains a concern. In present study, European seabass (Dicentrarchus labrax) reared under flow-through system (FAS) recirculating (RAS), were fed diets supplemented with FLO 10 d, followed by 20-d withdrawal period. The effects performance, intestinal...
Eggs are essential food sources as they provide low cost and high nutritional content of animal protein. The preservation period is one the apparent factors affecting egg quality. Previous studies based on traditional detection techniques demonstrated that storage would significantly influence weight, eggshell albumen height, haugh unit (HU) viscosity. Herein, we employed non-targeted metabolome technology to reveal comprehensive changes in metabolite composition duck eggs under impacts...
Oligoasthenoteratozoospermia (OAT) can result in male infertility owing to reduced sperm motility and abnormal spermatozoan morphology. The Tektins are a family of highly conserved filamentous proteins expressed the axoneme associated structures many different metazoan species. Earlier studies on mice identified Tektin3 (Tekt3) as testis-enriched gene, knockout Tekt3 resulted asthenozoospermia mice. Here, whole-exome sequencing 100 males with from unrelated families was performed, followed...
1. The avian gut hosts a complex and dynamic microbial ecosystem, which is essential for regulating host organ function. However, the relationship between microbiota hypothalamic axis in acute stress vulnerability ducks remains unclear.
Extramedullary disease (EMD) in multiple myeloma (MM) patients is an uncommon event and more attention was directed toward the feature of these patients. Cytogenetic aberration important characteristic MM associated with patients’ outcome. In this study, we aimed to compare cytogenetic abnormality without extramedullary manifestation, analyze clinical outcomes novel agents EMD We retrospectively investigated data from 41 Our analyses showed del(17p13) 31% versus 13% medullary (<mml:math...
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by memory loss and cognitive deficits accompanied neuronal damage cholinergic disorders. Sesamol, lignan component in sesame oil, has been proven to have neuroprotective effects. This research aimed investigate the preventive effects of sesamol on scopolamine (SCOP)-induced disorders C57BL/6 mice. The mice were pretreated with (100 mg/kg/d, p.o.) for 30 days. Behavioral tests indicated that supplement prevented...
Among many ecological services provided by mangrove ecosystems, soil organic carbon (SOC) storages have recently received much attention owing to the increasing atmospheric partial pressure of dissolved CO2 (pCO2). Bacteria are fundamental ecosystem functions and strongly influence coupling coastal carbon, nitrogen, sulfur cycling in soils. The SOC storage bacterial communities along a restored chronosequence Jiulong River Estuary were explored using 16S rDNA sequencing technique. results...
Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with 5-year survival rate of less than 20%. Therefore, it crucial to elucidate the molecular mechanisms ICC. Recently, advance high-throughput chromosome conformation capture (Hi-C) technology help us look insight into three-dimensional (3D) genome structure variation during tumorigenesis. However, its function in ICC pathogenesis remained unclear. Hi-C and RNA-sequencing were applied analyze 3D structures gene...
Asthenoteratozoospermia is one of the major factors for male infertility, whereas causes large numbers cases are still unknown. We identified compound heterozygous variants FSIP2 in three unrelated individuals from a cohort 105 patients with asthenoteratozoospermia by exome sequencing. Deleterious variations caused severe disassembly fibrous sheath and axonemal defects. Intriguingly, spermatozoa our study manifested "super-length" mitochondrial sheaths, increased levels outer membrane...
Urocortin (Ucn1), a member of corticotrophin-releasing hormone (CRH) family, has been reported to be upregulated in inflammatory diseases and function as an autocrine or paracrine mediator. Growing evidence shows that Ucn1 increases the endothelial permeability conditions; however, detailed mechanisms are not clear. In present study, we investigated increased by human umbilical vein cells (HUVECs) exposed lipopolysaccharide (LPS). Pretreatment HUVECs with cell permeability, which was...