A5085325895- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Prenatal Screening and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Bacterial Genetics and Biotechnology
- Sexual function and dysfunction studies
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Sexual Differentiation and Disorders
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Curcumin's Biomedical Applications
- Circular RNAs in diseases
- Genetic and Kidney Cyst Diseases
- RNA modifications and cancer
- Sexuality, Behavior, and Technology
- Nuclear Structure and Function
- Bacteriophages and microbial interactions
- Berberine and alkaloids research
- Hormonal and reproductive studies
Anhui Medical University
2016-2025
Peking University
2025
Peking University Third Hospital
2025
Second Hospital of Anhui Medical University
2016-2025
Oregon Health & Science University
2010-2025
Dartmouth College
2023-2025
State Key Laboratory of Remote Sensing Science
2024-2025
Beijing Normal University
2024-2025
Hebei Eye Hospital
2025
Shanghai Academy of Agricultural Sciences
2023-2025
Hypoxia-inducible factor 1 α (HIF1α) is an essential part of the HIF-1 transcriptional complex that regulates angiogenesis, cellular metabolism, and cancer development. In von Hippel-Lindau (VHL)-null kidney cell lines, we reported previously HIF1α proteins can be acetylated inhibited by histone deacetylase (HDAC) inhibitors or specific siRNA against HDAC4. To investigate mechanism biological consequence inhibition, have generated stable HDAC4 knockdown via shRNA in VHL-positive normal...
Abstract Background Animal domestication has been extensively studied, but the process of feralization remains poorly understood. Results Here, we performed whole-genome sequencing 99 sheep and identified a primary genetic divergence between 2 heterogeneous populations in Tibetan Plateau, including 1 semi-feral lineage. Selective sweep candidate gene analysis revealed local adaptations these associated with sensory perception, muscle strength, eating habit, mating process, aggressive...
Background The association between the TDRD6 variants and human infertility remains unclear, as only one homozygous missense variant of was found to be associated with oligoasthenoteratozoospermia (OAT). Methods Whole-exome sequencing Sanger were employed identify potential pathogenic in infertile men. Histology, immunofluorescence, immunoblotting ultrastructural analyses conducted clarify structural functional abnormalities sperm mutated patients. Tdrd6 -knockout mice generated using...
Abstract There is strong evidence that obesity a risk factor for poor semen quality. However, the effects of multigenerational paternal on susceptibility to cadmium (a reproductive toxicant)-induced spermatogenesis disorders in offspring remain unknown. Here, we show that, mice, and retinoic acid levels become progressively lower as number generations exposed high-fat diet increase. Furthermore, exposing several mice high fat results decrease expression Wt1, transcription upstream enzymes...
Objective This study aimed to evaluate the effects of tranexamic acid (TXA) in preventing postpartum haemorrhage (PPH) among women with identified risk factors for PPH undergoing vaginal delivery China.
Male infertility is a major concern affecting reproductive health. Biallelic deleterious variants of most DNAH gene family members have been linked to male infertility, with intracytoplasmic sperm injection (ICSI) being an efficacious way achieve offspring. However, the association between
Resistance to chemotherapy represents a significant obstacle in prostate cancer therapeutics. Novel mechanistic understandings cell chemotherapeutic sensitivity and resistance can optimize treatment improve patient outcome. Molecular alterations the metabolic pathways are associated with development; however, role of these efficacy is largely unknown.In bed-side bench-side reverse translational approach, we used cDNA microarray qRT-PCR identify genes that biochemical relapse after...
Abstract Despite recent advances, the efficacy of androgen/androgen receptor (AR)-targeted therapy remains limited for many patients with metastatic prostate cancer. This is in part because cancers adaptively switch to androgen/AR-independent pathway survival and growth, thereby conferring resistance. Tumor hypoxia considered as a major cause treatment However, exact mechanism largely unclear. Here we report that chronic-androgen deprivation (ADT) condition induces adaptive...
Male infertility is an increasingly serious health problem affecting couples of reproductive age. Mutations in axoneme-associated genes cause male infertility. Dynein arm proteins are essential sustaining normal axonemes and promote flagellar motility. However, the function DNAH7 fertility vivo remains unclear. Herein, we showed that disruption humans results infertility, which was characterised by multiple morphological abnormalities sperm flagella. The axoneme structure from a...
Abstract Background Potassium channels are important for the structure and function of spermatozoa. As a potassium transporter, mSlo3 is essential male fertility as Slo3 knockout mice were infertile with series functional defects in sperm cells. However, no pathogenic variant has been detected human SLO3 to date. Here we reported case homozygous mutation. The corresponding assisted reproductive strategy also investigated. Methods We performed whole-exome sequencing analysis from large cohort...
Non-obstructive azoospermia (NOA) is the most severe type of male infertility, affecting 1% men worldwide. Most its etiologies remain idiopathic. Although genetic studies have identified dozens NOA genes, monogenic mutations can also account for a small proportion idiopathic cases. Hence, this study was conducted to explore causes variants in cohort Chinese patients.Following screening using chromosomal karyotyping, Y chromosome microdeletion analyses, and sex hormone assessments, subsequent...
Abstract Background Multiple morphological abnormalities of the sperm flagella (MMAF) is a subtype severe asthenoteratozoospermia with poorly understood genetic etiology. SPAG6 core axonemal component that plays critical role in formation cilia and flagella. Previous studies have reported mutations cause primary ciliary dyskinesia (PCD), but association between gene variants MMAF phenotype has not yet been described. Methods We performed whole-exome sequencing (WES) two unrelated Han Chinese...
The ResD-ResE signal transduction system is essential for aerobic and anaerobic respiration in Bacillus subtilis. ResDE-dependent gene expression induced by oxygen limitation, but full induction under conditions requires nitrite or nitric oxide (NO). Here we report that NsrR (formerly YhdE) responsible the NO-dependent up-regulation of ResDE regulon. null mutation nsrR led to derepression hmp (flavohemoglobin gene) partly a ResDE-independent manner. In addition its negative role expression,...
ABSTRACT Bacillus subtilis produces an anionic bacteriocin called subtilosin A that possesses antibacterial activity against certain gram-positive bacteria. In this study, we uncovered a hemolytic mutant of B. altered form A. The bacteriocin, named A1, has replacement threonine at position 6 with isoleucine. addition to the activity, A1 was found exhibit enhanced antimicrobial specific bacterial strains. albB does not produce putative immunity peptide more sensitive both and A1. spontaneous...
Signaling through the VHL-PTP1B-Src pathway in renal cell carcinomas may determine sensitivity to Src inhibitors and provide a basis for treatment planning.
Abstract Background Asthenozoospermia is one of the most common causes male infertility, and its genetic etiology poorly understood. DNAH9 a core component outer dynein arms in cilia flagellum. It was reported that variants (OMIM: 603330) might cause primary ciliary dyskinesia (PCD). However, lead to nonsyndromic severe asthenozoospermia have yet be reported. Methods Whole exome sequencing (WES) performed for two individuals with from non-consanguineous families, Sanger verify identified...
Abstract Colorectal cancer is the second common cause of death worldwide. Lamin B2 (LMNB2) involved in chromatin remodeling and rupture reorganization nuclear membrane during mitosis, which necessary for eukaryotic cell proliferation. However, role LMNB2 colorectal (CRC) poorly understood. This study explored biological functions progression possible molecular mechanisms. We found that was significantly upregulated primary tissues lines, compared with paired non-cancerous normal epithelium....
Patient-derived organoids (PDO) have been proposed as a novel in vitro method of drug screening for different types cancer. However, to date, extrahepatic biliary tract carcinoma (eBTC) PDOs not yet fully established.We collected six samples gallbladder (GBC) and one sample cholangiocarcinoma (eCCA) from seven patients attempt establish eBTC screening. We successfully established five GBC eCCA PDOs. Histological staining was used compare structural features between the original tissues...
The growing consumption of Volvariella volvacea has heightened concerns regarding its geographical authenticity. This study analyzed the proteins, 16 common amino acids, and 10 mineral elements (Ca, Cu, Fe, K, Mn, Mg, Na, Se, Sr, Zn) in samples from Fujian, Guangdong, Hubei, Jiangsu, Jiangxi, Shanghai, Zhejiang, China, along with regional variations stable isotope ratios. PCA PLS-DA were applied for origin authentication. results showed an average protein content approximately 30 g/100 g...