A5091335645- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Prostate Cancer Treatment and Research
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- COVID-19 and healthcare impacts
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psoriasis: Treatment and Pathogenesis
- Health and Medical Studies
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- COVID-19 and Mental Health
- Cancer survivorship and care
- Medical Coding and Health Information
- Genetic factors in colorectal cancer
- Long-Term Effects of COVID-19
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Climate Change and Health Impacts
- Medication Adherence and Compliance
- Vitamin D Research Studies
- Exercise and Physiological Responses
- COVID-19 Clinical Research Studies
- Palliative Care and End-of-Life Issues
- Hormonal and reproductive studies
London School of Hygiene & Tropical Medicine
2016-2025
Bayer (Germany)
2025
Trinity College Dublin
2022
University of London
2020-2022
Transnational Press London
2021
Science Oxford
2021
University of Pennsylvania
2016
Atlantic Healthcare (United Kingdom)
2015
Royal Marsden NHS Foundation Trust
2011-2013
Institute of Cancer Research
2011-2012
Causes of mortality are a crucial input for health systems identifying appropriate interventions child survival. We present an updated series cause-specific neonates and children younger than 5 years from 2000 to 2019.
BackgroundThere are concerns that the response to COVID-19 pandemic in UK might have worsened physical and mental health, reduced use of health services. However, scale problem is unquantified, impeding development effective mitigations. We aimed ascertain what has happened general practice contacts for acute outcomes during pandemic.MethodsUsing de-identified electronic records from Clinical Research Practice Datalink (CPRD) Aurum (covering 13% population), between 2017 2020, we calculated...
Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that active in castration-resistant prostate cancer. Our objective was to determine the impact of abiraterone with and without dexamethasone treatment on vivo steroidogenesis. We treated 42 castrate, cancer patients continuous, daily prospectively collected blood urine before during after addition 0.5 mg daily. Treatment single-agent associated accumulation steroids mineralocorticoid properties upstream CYP17A1....
Abstract Background Eczema (atopic dermatitis) is a major global public health issue with high prevalence and morbidity. Our goal was to evaluate eczema over time, using standardized methodology. Methods The Global Asthma Network (GAN) Phase I study an international collaborative arising from the International Study of Allergies in Children (ISAAC). Using surveys, we assessed prevalence, severity, lifetime centres participating GAN (2015–2020) one/ both ISAAC (1993–1995) III (2001–2003). We...
Tumor genomic instability and selective treatment pressures result in clonal disease evolution; molecular stratification for molecularly targeted drug administration requires repeated access to tumor DNA. We hypothesized that circulating plasma DNA (cpDNA) advanced cancer patients is largely derived from tumor, has prognostic utility, can be utilized multiplex mutation sequencing when repeat biopsy not feasible. the Sequenom MassArray System OncoCarta panel somatic profiling. Matched...
The proportion of days covered (PDC) is used to estimate medication adherence by looking at the in which a person has access medication, over given period interest. This study aimed adapt PDC algorithm allow for plausible assumptions about prescription refill behaviour when applied data from online pharmacy suppliers.Three algorithms, conventional approach (PDC1) and two alternative approaches (PDC2 PDC3), were real-world dataset an pharmacy. Each different denominators increasing levels...
Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases risk stimulation increases risk. Establishing baseline in people is important before exploring the association new biologic drugs for risk.To investigate whether associated cancer.Matched cohort studies were conducted from January 2, 1998, to March 31, 2016, England 1, 1982, June 30, Denmark. We our analyses July 2018 2019. The setting was English primary care...
How international migrants access and use primary care in England is poorly understood. We aimed to compare consultation rates between non-migrants before during the COVID-19 pandemic (2015-2020).
Abstract Objectives: Visuospatial processing deficits have been reported in Huntington’s disease (HD). To date, no study has examined associations between visuospatial cognition and posterior brain findings HD. Methods: We compared 119 premanifest (55> 64<10.8 years to expected onset) 104 early symptomatic (59 stage-1 45 stage-2) gene carriers, with 110 controls on visual search mental rotation performance at baseline 12 months. In the groups, we also task severity, functional capacity...
Signaling through the VHL-PTP1B-Src pathway in renal cell carcinomas may determine sensitivity to Src inhibitors and provide a basis for treatment planning.
Atopic eczema is a common chronic inflammatory skin disease. Research suggests an association between atopic and obesity, with inconsistent evidence from European populations. To explore the diagnosed being overweight or obese, whether increased severity was associated higher body mass index. We undertook cross‐sectional analysis within cohort of adults (matched by age, sex general practice) without diagnosis eczema. used primary care (Clinical Practice Datalink Gold) linked hospital...
Atopic eczema affects up to 10% of adults and is becoming more common globally. Few studies have assessed whether atopic increases the risk death.We aimed determine with were at increased death overall by specific causes assess varied severity activity.The study was a population-based matched cohort using UK primary care electronic health records from Clinical Practice Research Datalink linked hospitalization data Hospital Episode Statistics mortality Office for National 1998 2016.A total...
<ns4:p><ns4:bold>Background: </ns4:bold>Patients surviving hospitalisation for COVID-19 are thought to be at high risk of cardiometabolic and pulmonary complications, but quantification that is limited. We aimed describe the overall burden these complications in people after discharge from hospital with COVID-19. </ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Working on behalf NHS England, we used linked primary care records, death certificate data OpenSAFELY platform. constructed three...
Abstract Background Psoriasis and atopic eczema are common inflammatory skin diseases. Existing research has identified increased risks of mental disorders (anxiety, depression) in people with psoriasis; however, explanations for the associations remain unclear. We aimed to establish risk factors illness those or psoriasis identify population groups most at risk. Methods used routinely collected data from UK Clinical Practice Research Datalink (CPRD) GOLD. Adults registered a general...
Circulating tumour cells (CTC) in patients with metastatic carcinomas are associated poor survival and can be used to guide therapy. Classification of CTC however remains subjective, as they morphologically heterogeneous. We acquired digital images, using the CellSearch™ system, from blood 185 castration resistant prostate cancer (CRPC) 68 healthy subjects define by computer algorithms. Patient data was training parameter for CTC. The computer-generated definition validated on a separate...