A5035355037- Dermatology and Skin Diseases
- Herpesvirus Infections and Treatments
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Medical Coding and Health Information
- Acne and Rosacea Treatments and Effects
- Urticaria and Related Conditions
- Grief, Bereavement, and Mental Health
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Chronic Disease Management Strategies
- Health and Medical Studies
- Skin Protection and Aging
- Allergic Rhinitis and Sensitization
- Genetic and rare skin diseases.
- Acute Myocardial Infarction Research
- Cancer and Skin Lesions
- Cervical Cancer and HPV Research
- Mast cells and histamine
- melanin and skin pigmentation
- Health Systems, Economic Evaluations, Quality of Life
- Biomedical Text Mining and Ontologies
- Nail Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Contact Dermatitis and Allergies
Aarhus University Hospital
2015-2024
Aarhus University
2018-2024
Stanford University
2022
Copenhagen University Hospital
2022
Rigshospitalet
2022
London School of Hygiene & Tropical Medicine
2016-2021
Central Denmark Region
2021
University of Manchester
2019
Manchester Academic Health Science Centre
2019
University College London
2019
In pharmacoepidemiology, routinely collected data from electronic health records (including primary care databases, registries, and administrative healthcare claims) are a resource for research evaluating the real world effectiveness safety of medicines. Currently available guidelines reporting using non-randomised, data—specifically REporting studies Conducted Observational Routinely Data (RECORD) Strengthening Reporting OBservational in Epidemiology (STROBE) statements—do not capture...
Hydrochlorothiazide, one of the most frequently used diuretic and antihypertensive drugs in United States Western Europe, is photosensitizing has previously been linked to lip cancer.To examine association between hydrochlorothiazide use risk basal cell carcinoma (BCC) squamous (SCC).From Danish Cancer Registry, we identified patients (cases) with nonmelanoma skin cancer (NMSC) during 2004-2012. Controls were matched 1:20 by age sex. Cumulative (in 1995-2012) was assessed from Prescription...
<h3>Abstract</h3> <h3>Objective</h3> To investigate whether adults with atopic eczema are at an increased risk of cardiovascular disease and the varies by severity condition activity over time. <h3>Design</h3> Population based matched cohort study. <h3>Setting</h3> UK electronic health records from Clinical Practice Research Datalink, Hospital Episode Statistics, data Office for National 1998–2015. <h3>Participants</h3> Adults a diagnosis eczema, (on age, sex, general practice, calendar...
Abstract Social isolation is associated with increased mortality. Meta-analytic results, however, indicate heterogeneity in effect sizes. We aimed to provide new evidence the association between social and mortality by conducting a population-based cohort study. reconstructed Berkman Syme’s network index (SNI), which combines four components of networks (partnership, interaction family/friends, religious activities, membership organizations/clubs) into an index, ranging from 0/1 (most...
Abstract Background Several antihypertensive drugs are photosensitizing and may therefore act as cocarcinogens with ultraviolet radiation. Objective To examine whether drug use is associated squamous cell carcinoma ( SCC ), basal BCC malignant melanoma MM ). Methods We used population‐based databases to conduct a case–control study including all first‐time cases of n = 2282), 17 242), 3660) in northern Denmark, 1991–2010. matched approximately 10 controls 231 743) each case by age, sex...
Association of Hydrochlorothiazide Use and Risk Malignant MelanomaWe have recently shown that hydrochlorothiazide use increases the risk lip nonmelanoma skin cancer, notably squamous cell carcinoma. 1,2It would substantial implications if carcinogenic effect also extended to malignant melanoma.Methods | Similarly our recent studies hydrochlorothiazide, 1,2 we identified histologically verified melanoma cases (January 2004 December 2015), each matched 1:10 (risk-set sampling; age, sex, date)...
Abstract Background Methotrexate (MTX) use has been suspected of increasing the risk skin cancer. The aim this investigation was to examine association between MTX and basal cell carcinoma (BCC), cutaneous squamous (cSCC) malignant melanoma (CMM). Methods In a nationwide Danish case–control study, we identified incident, histologically verified cases BCC ( n = 131,447), cSCC 18,661) or CMM (26,068) from 2004 2018. We matched 10 controls each case on sex birth year using risk-set sampling...
Objective To examine the association between exacerbation frequency and mortality following an acute of chronic obstructive pulmonary disease (AECOPD). Design Cohort study using medical databases. Setting Northern Denmark. Participants On 1 January 2005, we identified all patients with prevalent hospital-diagnosed (COPD) who had at least one AECOPD during 2005 to 31 December 2009. We followed from first this period until death, emigration or 2009, whichever came first. flagged events...
Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases risk stimulation increases risk. Establishing baseline in people is important before exploring the association new biologic drugs for risk.To investigate whether associated cancer.Matched cohort studies were conducted from January 2, 1998, to March 31, 2016, England 1, 1982, June 30, Denmark. We our analyses July 2018 2019. The setting was English primary care...
The antihypertensive agent hydrochlorothiazide has been associated with increased risks of non-melanoma skin cancer (NMSC) and possibly some melanoma subtypes. Previous studies were, however, conducted in predominantly Caucasian populations. We therefore examined the association between risk an Asian population.By using Taiwan's National Health Insurance Research Database (NHIRD), we three separate case-control lip cancer, non-lip melanoma. Cases (n = 29,082) a first-ever diagnoses...
Herpes zoster (HZ) is caused by reactivation of the neurotrophic varicella-zoster virus (VZV). Zoster may contribute to development dementia through neuroinflammation, cerebral vasculopathy, or direct neural damage, but epidemiologic evidence limited. We used data from linked nationwide Danish registries conduct a cohort study association between and during 1997-2017. As secondary aims, we examined whether associations were more pronounced for involving cranial nerves (mainly ophthalmic...
Atopic eczema affects up to 10% of adults and is becoming more common globally. Few studies have assessed whether atopic increases the risk death.We aimed determine with were at increased death overall by specific causes assess varied severity activity.The study was a population-based matched cohort using UK primary care electronic health records from Clinical Practice Research Datalink linked hospitalization data Hospital Episode Statistics mortality Office for National 1998 2016.A total...
Autoimmune blistering disorders (ABDs) might elevate cardiovascular risk, but studies are lacking.
Ectodermal dysplasias constitute a group of rare genetic disorders the skin and appendages with hypodontia, hypotrichosis, hypohidrosis as cardinal features. There is lack population-based research into epidemiology ectodermal dysplasias.
Phosphodiesterase 5A inhibitors (PDEIs), a common treatment for erectile dysfunction, were recently linked to an increased risk of melanoma. We conducted two parallel case–control studies, using the Danish Nationwide Health Registries (DNHR) and Kaiser Permanente Northern California (KPNC) electronic health records. Identifying men with histologically verified melanoma (cases) matched on birth year 10 cancer-free controls, we estimated odds ratios (OR) associated high use PDEIs (⩾100 tablets...
Cancer patients may be at decreased risk of Alzheimer's disease. This hypothesis is best developed for non-melanoma skin cancer (NMSC), but supportive epidemiological data are sparse. We therefore conducted a nationwide cohort study the association between NMSC and disease (main outcome) all-cause dementia. Using Danish medical databases, we identified adults diagnosed with 1 January 1980 30 November 2013 (n = 216,221) comparison five individuals matched to each patient by sex birth year...
To develop and validate the DANish Comorbidity index for Acute Myocardial Infarction (DANCAMI) adjustment of comorbidity burden in studies myocardial infarction prognosis.Using medical registries, we identified patients with first-time Denmark during 2000-2013 (n=36,685). We developed indices predicting 1-year all-cause mortality from all comorbidities restricted to non-cardiovascular (rDANCAMI). For variable selection, eliminated stepwise using hazard ratios multivariable Cox models....
Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial.To examine the association between perceived psychological and risk of HZ.In a linked registry-based cohort study, we followed 77 310 persons aged 40 years or older who participated 2010 Danish National Health Survey from 1 May until HZ diagnosis, death, emigration July 2014, whichever occurred first. We computed hazard ratios (HRs) associated with...
Atopic dermatitis (AD) may affect academic performance through multiple pathways, including poor concentration associated with itching, sleep deprivation, or adverse effects of medications. Because educational attainment is health and well-being, any association a prevalent condition such as AD major importance.