A5013739905- Dermatology and Skin Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psoriasis: Treatment and Pathogenesis
- COVID-19 Clinical Research Studies
- Healthcare cost, quality, practices
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Food Allergy and Anaphylaxis Research
- Adrenal Hormones and Disorders
- Health and Medical Studies
- Vitamin D Research Studies
- Allergic Rhinitis and Sensitization
- Autopsy Techniques and Outcomes
- Bone health and osteoporosis research
- COVID-19 and healthcare impacts
- Chronic Kidney Disease and Diabetes
- Data Quality and Management
- Spondyloarthritis Studies and Treatments
- Statistical Methods in Clinical Trials
- Biosensors and Analytical Detection
- Travel-related health issues
- SARS-CoV-2 and COVID-19 Research
- Health, psychology, and well-being
- Multiple Sclerosis Research Studies
- Sepsis Diagnosis and Treatment
London School of Hygiene & Tropical Medicine
2021-2025
University of London
2021-2025
Centre de Recherche Médicales de Lambaréné
2019-2020
Bernhard Nocht Institute for Tropical Medicine
2020
University Medical Center Hamburg-Eppendorf
2020
Universität Hamburg
2020
University of Tübingen
2020
The risk of severe COVID-19 outcomes in people with immune-mediated inflammatory diseases and on immune-modifying drugs might not be fully mediated by comorbidities vary factors such as ethnicity. We aimed to assess the adults those therapies.
Abstract Background Psoriasis and atopic eczema are common inflammatory skin diseases. Existing research has identified increased risks of mental disorders (anxiety, depression) in people with psoriasis; however, explanations for the associations remain unclear. We aimed to establish risk factors illness those or psoriasis identify population groups most at risk. Methods used routinely collected data from UK Clinical Practice Research Datalink (CPRD) GOLD. Adults registered a general...
Abstract Objective Evidence for an association between psoriasis and dementia is limited conflicting. We aimed to investigate the using large representative population‐based data describe risk by subtype over time. Methods compared people with without age‐, sex‐ primary care practice‐matched cohort of adults aged ≥40 years from Clinical Practice Research Datalink Aurum in England (1997–2021) linked hospital admissions data, analysed stratified Cox regression. Results Among 360,014...
Atopic eczema may be associated with multiple health conditions. Here, we systematically explored risks across the full spectrum based on International Classification of Diseases, assessing associations between and 2,058 ICD-10 codes, 1,593 phecodes, 201 Global Burden Disease codes. In English primary care electronic records (1997−2023) identified cohorts people (up to 3 million) compared matched comparators (individuals without (by age, sex, general practice) 14 million). up 25 years...
Whilst a quarter of the world's population is estimated to be infected with Mycobacterium tuberculosis, it unknown whether TB infection (TBI) increases risk severe COVID-19, which relevant in TB-endemic settings, especially where HIV co-infection also common. A convenience cohort symptomatic and asymptomatic COVID-19 patients aged 8-80 years western Kenya was followed daily for 14 days assess disease progression using validated inFLUenza-Patient-Reported-Outcome Plus signs symptom tool....
<ns4:p>Background Codelists are required to extract meaningful information on characteristics and events from electronic health records (EHRs). EHR research relies codelists define study populations variables, thus, trustworthy important. Here, we provide a checklist, in the style of commonly used reporting guidelines, help researchers adhere best practice codelist development sharing. Methods Based literature search workshop with experienced created set recommendations that 1. broadly...
<ns4:p>Background Codelists are required to extract meaningful information on characteristics and events from routinely collected health data such as electronic records. Research using relies codelists define study populations variables, thus, trustworthy important. Here, we provide a checklist, in the style of commonly used reporting guidelines, help researchers adhere best practice codelist development sharing. Methods Based literature search workshop with experienced use data, created set...
BackgroundEvidence suggests adults with atopic eczema have increased fracture risk. However, it is unclear whether oral corticosteroids explain the association.ObjectiveTo assess to what extent mediate relationship between and fractures.MethodsWe conducted a cohort study using English primary care (Clinical Practice Research Datalink) hospital admissions (Hospital Episode Statistics) records (1998–2016) including (18 years old older) matched (age, sex, general practice) up 5 without eczema....
At the outset of COVID-19 pandemic, there was no routine comprehensive hospital medicines data from UK available to researchers. These records can be important for many analyses including effect certain on risk severe outcomes. With approval NHS England, we set out obtain one specific group medicines, "high-cost drugs" (HCD) which are typically specialist management long-term conditions, prescribed by hospitals patients. Additionally, aimed make these all approved researchers in...
Background: Existing research exploring associations between atopic eczema (AE) or psoriasis, and severe mental illness (SMI – ie, schizophrenia, bipolar disorder, other psychoses) is limited, with longitudinal evidence particularly scarce. Therefore, temporal directions of are unclear. We aimed to investigate AE psoriasis incident SMI among adults. Methods: conducted matched cohort studies using primary care electronic health records (January 1997 January 2020) from the UK Clinical Practice...
Malaria remains a public health issue, particularly in sub-Saharan Africa with special features of seriousness young children and pregnant women. Adolescents adults are reported to have acquired semi-immune status and, therefore, present low parasitaemia. Children understood much higher parasitaemia severe malaria. It is concern that effective malaria control programmes targeting may lead delay the acquisition immunity causing shift epidemiology Prevalence were explored adolescents...
Introduction: Previous research has shown associations between eczema and psoriasis anxiety depression. We investigated whether are consistent across different settings of ascertainment for depression anxiety, including interview survey responses from UK Biobank (a large longitudinal cohort recruiting individuals aged 40– 69 years 2006– 2010), linked primary care data, with the aim drawing more reliable conclusions through triangulation. Methods: In cross-sectional studies, we estimated or...
Abstract Background Acute Kidney Injury (AKI) is a multifactorial condition which presents substantial burden to healthcare systems. There limited evidence on whether it seasonal. We sought investigate the seasonality of AKI hospitalisations in England and use unsupervised machine learning explore clustering underlying comorbidities, gain insights for future intervention. Methods used Hospital Episodes Statistics linked Clinical Practice Research Datalink describe overall incidence...
Abstract Atopic eczema may be related to multiple subsequent adverse health outcomes. Here, we provide evidence judge and compare associations between a comprehensive set of We conducted 71 cohort studies (age, sex, general practice-matched) using Clinical Practice Research Datalink Aurum primary care records (1997−2023), comparing up 3.6 million people with 16.8 without. Eczema was associated diagnosis outcomes adjusted hazard ratios (99% confidence intervals) from Cox regression...
Background It is unclear whether individual treatment of scabies similarly effective compared to household treatment. This study these two strategies with topical benzyl benzoate for treating in Lambaréné, Gabon. Methods Participants presenting uncomplicated were randomized into either the Individual Treatment group, where only affected participants received treatment, or Household all family members treated parallel regardless signs and symptoms. The primary endpoint was clinical cure after...
Eczema and asthma are allergic diseases two of the commonest chronic conditions in high-income countries. Their co-existence with other is common, but little research exists on wider multimorbidity these conditions. We set out to identify compare clusters people eczema or without. Using routinely-collected primary care data from U.K. Clinical Research Practice Datalink GOLD, we identified adults ever having (or asthma), comparison groups never asthma). derived hierarchical cluster analysis...
Identifying and mitigating modifiable gaps in fracture preventive care for people with relapsing-remitting conditions such as eczema, asthma, chronic obstructive pulmonary disease who are prescribed high cumulative oral corticosteroid doses may decrease fracture-associated morbidity mortality.
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Abstract The rapid emergence and global dissemination of SARS-CoV-2 highlighted a need for robust, adaptable surveillance systems. However, financial infrastructure requirements whole genome sequencing (WGS) mean most data have come from higher-resource geographies, despite unprecedented investment in low-middle income countries (LMICs) throughout the pandemic. Consequently, molecular epidemiology some LMICs is limited, there more cost-accessible technologies to help close gaps variants. To...
Subtypes of atopic dermatitis (AD) have been derived from the Avon Longitudinal Study Parents and Children (ALSPAC) based on presence severity symptoms reported in questionnaires (severe-frequent, moderate-frequent, moderate-declining, mild-intermittent, unaffected-rare). Good agreement between ALSPAC linked electronic health records (EHRs) would increase trust clinical validity these subtypes allow inference EHRs alone, which enable their study large primary care databases.
Abstract Background Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared an older alternative, warfarin using primary care data in the United Kingdom (UK). However, other studies observed contradictory findings. We therefore aimed investigate association between and warfarin, DOACs. Methods conducted cohort UK Clinical Practice Research Datalink (CPRD) Aurum Hong Kong Data Analysis Reporting System (CDARS) identify hazard mortality,...
Abstract Background Substantial evidence suggests association between increased inflammatory markers and Alzheimer’s disease. However, for the skin disease psoriasis dementia is limited conflicting. Additionally, few studies investigate how severity influences risk. Method We used primary care electronic health records from UK’s Clinical Practice Research Datalink Aurum linked hospital admissions data a matched cohort study (1997‐2022) of individuals ≥40years. (age, sex, practice) with...
ABSTRACT Background It is unclear if people with immune-mediated inflammatory diseases (IMIDs) (joint, bowel and skin) on immune modifying therapy have increased risk of serious COVID-19 outcomes. Methods With the approval NHS England we conducted a cohort study, using OpenSAFELY, analysingroutinely-collected primary care data linked to hospital admission, death previously unavailable prescription data. We used Cox regression (adjusting for confounders) estimate hazard ratios (HR) comparing...