A5050524385- Natural product bioactivities and synthesis
- Marine Sponges and Natural Products
- Natural Compounds in Disease Treatment
- Bioactive Compounds and Antitumor Agents
- Liver Disease Diagnosis and Treatment
- Hops Chemistry and Applications
- Phytochemistry and Biological Activities
- Fibroblast Growth Factor Research
- Seaweed-derived Bioactive Compounds
- Esophageal and GI Pathology
- Mass Spectrometry Techniques and Applications
- Porphyrin Metabolism and Disorders
- Sesquiterpenes and Asteraceae Studies
- Infections and bacterial resistance
- Analytical chemistry methods development
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Kidney Stones and Urolithiasis Treatments
- Synthesis of heterocyclic compounds
- Phytochemistry and Bioactive Compounds
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Pesticide Residue Analysis and Safety
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Wenzhou Medical University
2016-2025
Hunan University of Traditional Chinese Medicine
2024
Chonnam National University
2021
A simple, rapid, sensitive, selective, and environmentally friendly method, based on a dispersive micro solid-phase extraction approach (dispersive SPE) coupled with liquid chromatography–high-resolution mass spectrometry (LC-HRMS), was established for the analysis of sulfonamides in honey milk. An efficient nontargeted screening strategy designed to discover identify known unknown milk using full-MS/all ion fragmentation (AIF) acquisition mode. The experimental parameters conditions SPE...
Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon, and its incidence on rise worldwide. Resveratrol (RSV), polyphenolic compound, was recently indicated to exert anti-inflammatory effects UC. Consequently, current study conducted investigate mechanism of RSV alleviating UC in mice by mediating intestinal microflora homeostasis. First, potential targets may regulate were screened using TCMSP database. Next, treated differently, specifically subjected...
This study aimed to explore the effects of plumbagin on rheumatoid arthritis (RA) and its mechanism. The RA cell model was simulated following treatment interleukin-1β (IL-1β). After various concentrations plumbagin, impact viability examined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. collagen-induced (CIA) established using solution bovine type II collagen. Hematoxylin-eosin staining used observe changes ankle joint tissue, while enzyme-linked immunosorbent...
Four new steroids, named 7-dehydroerectasteroid F (1), 11α-acetoxyarmatinol A (2), 22,23-didehydroarmatinol (3), and 3-O-acetylhyrtiosterol (4), together with 11 previously described analogues, were isolated from a South China Sea collection of the soft coral Dendronephthya gigantea. The structures steroids elucidated by comprehensive spectroscopic analysis comparison reported data. Compound 1 showed potent protection against H2O2-induced oxidative damage in neuron-like PC12 cells promoting...
Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures compounds determined by extensive spectroscopic analysis comparison previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring...
Five new diterpenes, including four hydroazulenes, (8R,11R)-8,11-diacetoxypachydictyol A (1), (8R*,11R*)-6-O-acetyl-8-acetoxy-11-hydroxypachydictyol (2), (8R*,11S*)-8-acetoxy-11-hydroxypachydictyol (3), and (8R*,11S*)-6-O-acetyl-8,11-dihydroxypachydictyol (4), a secohydroazulene derivative, named 7Z-7,8-seco-7,11-didehydro-8- acetoxypachydictyol (5), were isolated from South China Sea collection of Dictyota sp. nov. brown alga, together with five known analogues (6–10). Structure elucidation...
An overload of hepatic fatty acids, such as oleic acid is a key trigger non-alcoholic liver disease (NAFLD). Here, we investigated whether Artemisia frigida , valuable traditional medicine used to treat various diseases, could mitigate OA-induced lipid accumulation in HepG2 cells. Then, identify the active substances A. phytochemistry investigation was conducted using bioassay-guided isolation method. Consequently, one terpene ( 1 ) and flavone 2 were identified. Compound...
Liver fibrosis (LF) is a common sequela to diverse chronic liver injuries, leading rising rates of cirrhosis and hepatocellular carcinoma (HCC). As the medicinal edible homologous material, traditional teas have exhibited promising applications in clinical management fibrosis. Here, we generated mouse model explore potent therapeutic ability Ampelopsis grossedentata (AG) tea on this condition by multi-omics analysis. The biochemistry results pointed towards mitigated increases ALT, AST,...
Two new prenylated flavonoid glycosides (1-2), together with five known compounds (3-7) were isolated from the EtOAc-soluble extract of stems Celastrus orbiculatus. The structures elucidated spectroscopic and physico-chemical analyses. All isolates evaluated for in vitro cytotoxic activities against HepG2, MCF-7, A549, A2780 cancer cells. Among them, compound 1 showed potential antiproliferative activity on cells IC50 value 10.76 μM. In addition, 2 exhibited selective 26.30
Two new flavonoid glycosides named 6-hydroxy-3-methoxy-apigenin 7-O-α-ʟ-rhamnopyranoside (1) and 3-hydroxyl-apigenin 8-C-β-ᴅ-xylopyranoside (2), along with five known compounds (3-7), were isolated from Xanthium strumarium. Their structures elucidated on the basis of spectroscopic physicochemical analyses. All evaluated for in vitro inhibitory activity against PTP1B. Among them, 1 5 showed significant PTP1B IC50 values 11.3 ± 1.7 8.9 0.7 μM, respectively.
马尔尼菲蓝状菌是一种双相型条件致病菌，是HIV感染者常见的条件致病菌之一，亦可发现于HIV阴性但免疫功能受损的人群中。该菌感染常见的临床表现包括发热、贫血、咳嗽、体重减轻、肝脾及淋巴结肿大和特征性皮损，以消化道症状为主要表现者较少。本文报道1例免疫性血小板减少症合并马尔尼菲蓝状菌病，最终死于消化道出血的患者。