A5100631019- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Berberine and alkaloids research
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Eicosanoids and Hypertension Pharmacology
- MicroRNA in disease regulation
- Photoreceptor and optogenetics research
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Gut microbiota and health
- Diet and metabolism studies
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
- Helminth infection and control
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Gene Regulatory Network Analysis
- Ginger and Zingiberaceae research
Hunan Agricultural University
2021-2025
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Beijing Jishuitan Hospital
2022-2024
Peking University
2022-2024
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2019-2024
Chinese Academy of Agricultural Sciences
2019-2024
Zhengzhou University
2024
Ministry of Agriculture and Rural Affairs
2024
Zhengzhou Children's Hospital
2024
Neonatal calf diarrhea (NCD) is one of the most serious health challenges facing livestock industry and has caused substantial economic losses due to increased morbidity mortality rates. The present study investigated main infectious pathogens causing NCD among cattle in Yangxin County, China. Sixty-nine fecal samples were collected from diarrheic newborn tested for agents, including bovine rotavirus, coronavirus, Escherichia coli K99, Cryptosporidium parvum , Giardia lamblia that cause NCD,...
Oxyclozanide is an effective anthelmintic and has shown good properties in other ways including anti-adenovirus, anti-biofilm, antifungal, antibacterial activity. This study aimed to investigate the acute subacute 28-days repeated dose oral toxicity of oxyclozanide suspension Wistar rats. A high lethal (LD50) 3,707 mg/kg was observed test. During time period, no obvious adverse effects or death were detected. Histopathological changes heart, liver, kidney animals treated with oxyclozanide....
As a common complication of coronary microembolization (CME), myocardial injury (MI) implies high mortality. Long non-coding RNAs (lncRNAs) are rarely studied in CME-induced MI. Herein, this study intended to evaluate the role lncRNA Sox2 overlapping transcript (Sox2OT) The CME rat models were successfully established by injection microemboli. Rat cardiac functions and MI observed ultrasonic electrocardiogram, HE staining, HBFP staining. Functional assays utilized test inflammatory...
Abstract Oncogenic mutations of the receptor tyrosine kinase KIT drive cancers such as gastrointestinal stroma tumors (GIST) and systemic mastocytosis (SM). The in juxtamembrane domain (Exon 11, E11) extracellular (E9) are most commonly found GIST, A-Loop D816V mutation (E17) over 90% SM cases. Currently approved inhibitors either lacked efficacy against certain mutants, like imatinib, or selectivity multi-kinase targeting sunitinib regorafenib. Primary acquired resistance intolerance is...
To evaluate the safety of ivermectin microemulsion injection, 100 Wistar rats were injected intraperitoneally at 0.38 g/kg, 0.19 and 0.1 g/kg for 14 days. The 14-day repeated toxicity test injection was systematically evaluated by clinical observation, organ coefficient, hematological examination, chemistry histopathological examination. results showed that no died during test. At initial stage treatment, in high dose group had mild reaction, which disappeared after 4 Clinical could cause...
Macleaya cordata (Willd). R. Br. is a Chinese medicinal plant commonly used externally to treat inflammatory-related diseases such as arthritis, sores, and carbuncles. This study aimed evaluate the anti-inflammatory activity of protopine total alkaloids (MPTAs) in (Willd.) vivo tests rats with acute inflammation showed that MPTA (2.54 5.08 mg/kg) significant 6 h after carrageenan injection. Similarly, (3.67 7.33 mouse ear swelling test. In addition, potential mechanisms effects were explored...
Bacteria are among the important factors that play a role in balance of human health, and their relationship with some tumors has been well established.However, association between bacteria colonizing vocal cords glottic laryngeal squamous cell carcinoma (GLSCC) remains unclear.Here, we investigated whether bacterial communities cord mucous membrane development GLSCC.We collected tumor tissue normal adjacent (NAT) samples from 19 GLSCC patients, were compared control (control) 21 polyps...
CTX-M extended spectrum beta-lactamase-producing
The protopine alkaloids are widely distributed within the opium poppy family and have a wide range of pharmacological effects. MPTA is product total extracted from Macleaya cordata (Willd.) R. Br. Previously, we reported good anti-inflammatory activity as well oral acute sub-chronic toxicity studies in rats. In order to perform systematic toxicological safety assessment MPTA, toxicity, genotoxicity (bone marrow cell chromosome aberration test, sperm abnormality bone micronucleus rat...
Macleaya cordata extract (MCE) is widely used for its diverse pharmacological actions and beneficial effects on farm animals. Modern studies have shown that it has anti-inflammatory, anti-cancer, anti-bacterial activities, gradually becoming a long-term additive veterinary drug to improve animal intestinal health growth performance. Although some evidence points the DNA mutagenic potential of sanguinarine (SAN), major component MCE, there lack sufficient basic toxicological information oral...
Yaks and Tibetan sheep are important renowned livestock of the Qinghai-Tibetan Plateau (QTP). Both host genetics environmental factors can shape composition gut microbiota, however, there is still no consensus on which more dominant factor. To investigate influence hosts seasons microbiome diversity component, we collected fecal samples from yaks across different (summer winter), during they consumed diets. Using 16S rRNA sequencing, principal component analysis (PCoA) data showed that PCo1...
Abstract Objective This study was carried out to investigate the preliminary evaluation of effectiveness protopine total alkaloids Macleaya cordata (Willd.) R. Br. (MPTA) extract in control artificially infected avian pathogenic E. coli peritoneal cavity chickens. Methods In this test, Lingnan yellow hybrid chickens (male, 10 days old) were attacked with O78 and then treated orally different concentrations (25 - 1600 mg/kg) MPTA Pulvis (MPTA-P) 0.5% Siweichuanxinlian Powder (SWCXL-P)....
Rotator cuff tears (RCT) can cause shoulder pain, weakness and stiffness, significantly affecting daily life. Analysis of the GSE103266 dataset revealed significant changes in mTOR/PI3K/Akt signaling pathway lipid metabolism‑related pathways, suggesting that fatty infiltration may affect RCT. The analysis indicated ubiquitin ligase NEDD4 plays a critical role was found to be highly associated with pathway. An RCT model Sprague‑Dawley (SD) rats established study regulating mTOR investigate...
Based on network pharmacological analysis and molecular docking techniques, the main components of M. cordata for treatment bovine relevant active compounds in were searched through previous research bases literature databases, then screened to identify candidate based physicochemical properties, pharmacokinetic parameters, bioavailability, drug-like criteria. Target genes associated with hoof disease obtained from GeneCards database. Compound-target, compound-target-pathway-disease...
Circ-PDCD11 (hsa_circ_0019853, 461 bp) has been characterized as an oncogenic circRNA in breast cancer, while its function other cancers is unclear. In this study, we explored the role of circ-PDCD11 lung cancer.Plasma samples were obtained from patients with large-cell carcinoma (LLCC, n = 40), squamous cell (LSCC, adenocarcinoma (LA, 40) and small-cell cancer (SCLC, well healthy controls (Control, 40). Paired tumor nontumor tissue all patients. Expression these was determined by RT-qPCR....