A5100380555- CAR-T cell therapy research
- Insect and Pesticide Research
- Healthcare and Venom Research
- Insect and Arachnid Ecology and Behavior
- Acute Lymphoblastic Leukemia research
- Health disparities and outcomes
- Immunotherapy and Immune Responses
- Nutritional Studies and Diet
- Neonatal Respiratory Health Research
- Cardiovascular Health and Risk Factors
- Nutrition, Genetics, and Disease
- Virus-based gene therapy research
- Birth, Development, and Health
- SARS-CoV-2 and COVID-19 Research
- Polysaccharides and Plant Cell Walls
- Nutrition and Health in Aging
- Health, Environment, Cognitive Aging
- Dementia and Cognitive Impairment Research
- Immune Cell Function and Interaction
- Health and Wellbeing Research
- Folate and B Vitamins Research
- Frailty in Older Adults
- Artificial Intelligence in Healthcare and Education
- Nanowire Synthesis and Applications
- Congenital Diaphragmatic Hernia Studies
Second Hospital of Anhui Medical University
2023-2025
Anhui Medical University
2023-2025
Wenzhou Medical University
2025
Fudan University
2017-2025
Guangzhou Medical University
2022-2024
Shanghai Medical College of Fudan University
2020-2024
Third Affiliated Hospital of Guangzhou Medical University
2022-2024
Bristol-Myers Squibb (United States)
2024
Shanghai Polytechnic University
2024
Nankai University
2023
During recent decades China has undergone a rapid transition in the main disease patterns of its population. There been substantial decrease maternal and child mortality adult from themain infectious/parasitic diseases, whereas for ischaemic heart some other non-communicable chronic there moderate increase rates, at least parts China. Consequently, most premature that still remains now involves diseases middle age, such as cancer, stroke, disease, or lung disease. 1–4 In mid-1970s...
Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within receptor binding domain (RBD) spike (S) protein, lead to functional alteration both engagement monoclonal antibody (mAb) recognition. Here, we review data RBD point mutations possessed by major discuss their individual effects on ACE2 affinity immune evasion. Many single amino acid...
Information is the end of big data resource system construction, providing a source fresh water for resources and an important foothold demand. This paper analyzes current situation problems smart campus construction under background informatization. The practical needs development goals are analyzed, four core directions quasi business architecture, application technical architecture explored. In response to shortcomings in information capabilities, ownership, nodes, talents, should be key...
Abstract Background Epstein-Barr virus (EBV) is an oncovirus belonging to the herpesvirus family, associated with pathogenesis of multiple malignancies, particularly Burkitt lymphoma (BL). The remains latent in host cells and plays a critical role tumor progression through various mechanisms. A key glycoprotein, gp350, expressed during lytic phase EBV, instrumental viral entry into B presents unique antigenic target, making it promising candidate for immunotherapeutic approaches, such as...
A schematic diagram showing the IRS1-GLUT4 insulin signaling pathway influenced by PTP1B and FYGL in L6 cells.
In the absence of an effective treatment to alter progressive course cognitive decline and dementia, identification modifiable risk factors that could promote healthy aging has become a public health research priority. This study seeks comprehensively determine contemporaneous associations broad spectrum time-varying lifestyle with age-related in large population-based cohort older adults. A total 5711 subjects aged 50 from WHO Study on global AGEing adult (SAGE) Shanghai were studied....
The causal relationship between serum ferritin and metabolic syndrome (MetS) remains inconclusive. Dietary iron intake increases ferritin. objective of this study was to evaluate associations total, heme, nonheme dietary with MetS its components in men women metropolitan China. Data from 3099 participants the Shanghai Diet Health Survey (SDHS) obtained during 2012⁻2013 were included analysis. assessed by 24-h diet records 3 consecutive days. Multivariate generalized linear mixed models used...
Background Resistance to existing therapies is a major cause of treatment failure in patients with refractory and relapsed B-cell non-Hodgkin’s lymphoma (r/r B-NHL). Therapy-induced senescence (TIS) one the most important mechanisms drug resistance. Methods This study used single-cell RNA sequencing analyze doxorubicin-induced senescent B-NHL cells. C-C chemokine receptor 7 (CCR7) expression aggressive was assessed using immunohistochemistry flow cytometry. Lentiviral transfection target...
The primary challenges in CD19-specific chimeric antigen receptor T-cell (CD19 CAR T) therapy for patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL) are non-response and relapse; it is urgent to reveal these mechanisms. Neutrophils play a critical role the immunosuppressive tumor microenvironment (TME), which can hinder T efficacy. Our previous research identified subset of neutrophils special phenotype (CD14-CD10-CD45-HLA-DR-SSC++, termed CD10- neuts),...
Background/Objectives: The antibody-dependent enhancement (ADE) of viral entry has been documented for SARS-CoV-2 infection both in vitro and vivo. However, the potential vaccination to elicit similar ADE effects remains unclear. Methods: In this study, we assessed monoclonal antibodies (mAbs) derived from individuals vaccinated with inactivated vaccine compared them those one convalescent donor. Results: Our analysis revealed no significant difference binding affinity or neutralizing...
Mitochondrial dysfunction is implicated in the progression of diabetic kidney disease (DKD). Damaged mitochondria produce excessive reactive oxygen species (ROS) that can cause apoptosis. dynamics control quality and function mitochondria. Targeting mitochondrial may reduce ROS-induced apoptosis improve renal injury DKD. Modified Hu-lu-ba-wan (MHLBW) shows distinct clinical effects on DKD patients, which are related to its role antioxidant stress modulation. However, relevant mechanisms...
Background: The associations between dietary cholesterol and fatty acids serum lipids are controversial. This study is to examine the association of with dyslipidemia in Chinese metropolitan male female adults. Methods: 3850 participants Shanghai Diet Health Survey were investigated during period 2012–2013. Information was obtained on intake, anthropometric blood laboratory measurements. Dyslipidemia determined by US National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP...
Striking antibody evasion by emerging circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during evolution is still elusive. Here, we identify clonally related family from convalescent individual. One members, XG005, exhibits potent and broad activities against SARS-CoV-2 variants, while other members show significant reductions in...
Hepatocellular carcinoma (HCC) is a highly vascularized tumor with poor prognosis. Novel vascular-related therapeutic targets and prognostic markers remain urgently needed.To investigate the role mechanism of CLCA1 in hepatocellular carcinoma.Immunofluorescence, Co-immunoprecipitation rescue experiment were used to determine specific mechanisms CLCA1. Chemosensitivity assay was measure impact on Sorafenib.CLCA1 dramatically downregulated cell lines tissues. Ectopic expression induced...
The objective of this study was to assess the feasibility and effectiveness a novel WeChat applet-based personalized dietary intervention aimed at promoting healthier intakes. A two-arm parallel, randomized, controlled trial conducted in real-world scenario involved total 153 participants (the group, n = 76; control 77), lasting for 4 months Shanghai, China. group had access visualized nutrition evaluations through applet during workday lunch time, while received no interventions. 3413...
Background: Iron, zinc and magnesium perform differently in body metabolism but exist similar food. This study was to evaluate the associations of dietary iron, with metabolic syndrome (MetS). Methods: A sample a total 5323 participants from four China’s mega cities included current study. Both 3-day 24-h recall household condiment weighing were applied assess intake, respectively. Hierarchical logistic regression models used MetS. Results: After adjusting for age, sex, region, years...
There is a lack of studies comparing hypertension and comorbidities in rural urban older people China. This study aimed to investigate the prevalence describe differences between patients from areas China.A cross-sectional on global AGEing adult health (SAGE) was conducted 2007 2010 across 8 provinces The current included nationally representative subsample 7,403 respondents aged 60 years above. Hypertension either self-reported diagnosed or 1 elevated measured blood pressure measurement...