A5100612101- Cardiac Ischemia and Reperfusion
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Wastewater Treatment and Nitrogen Removal
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Hepatitis B Virus Studies
- Intermetallics and Advanced Alloy Properties
- Fluid Dynamics and Heat Transfer
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Microbial Community Ecology and Physiology
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- Shape Memory Alloy Transformations
- Cerebral Palsy and Movement Disorders
- Constructed Wetlands for Wastewater Treatment
- Autophagy in Disease and Therapy
- Soil Mechanics and Vehicle Dynamics
- Cancer, Hypoxia, and Metabolism
- Corneal Surgery and Treatments
- Titanium Alloys Microstructure and Properties
- Heart Failure Treatment and Management
- PARP inhibition in cancer therapy
Nanning Normal University
2025
Yunnan University
2025
China Rehabilitation Research Center
2022-2025
Shanxi Agricultural University
2020-2024
Zhejiang Gongshang University
2024
Hebei Provincial Center for Disease Control and Prevention
2024
Lanzhou University of Technology
2024
Capital Medical University
2022-2023
National Rehabilitation Center
2023
Harbin Institute of Technology
2022-2023
Abstract Lychee is an exotic tropical fruit with a distinct flavor. The genome of cultivar ‘Feizixiao’ was assembled into 15 pseudochromosomes, totaling ~470 Mb. High heterozygosity (2.27%) resulted in two complete haplotypic assemblies. A total 13,517 allelic genes (42.4%) were differentially expressed diverse tissues. Analyses 72 resequenced lychee accessions revealed independent domestication events. extremely early maturing cultivars preferentially aligned to one haplotype domesticated...
Adiponectin (APN) is a cardioprotective molecule. Its reduction in diabetes exacerbates myocardial ischemia/reperfusion (MI/R) injury. Although APN administration animals attenuates MI/R injury, multiple factors limit its clinical application. The current study investigated whether AdipoRon, the first orally active molecule that binds receptors, may protect heart against and if so, to delineate involved mechanisms. Wild-type (WT), knockout (APN-KO), cardiomyocyte specific-AMPK dominant...
Background— The inhaled anesthetic sevoflurane has been demonstrated to protect against myocardial ischemia/reperfusion (MI/R) injury via mechanisms involving AMP-activated protein kinase (AMPK) and caveolin-3 (Cav-3). However, the relative contributions of AMPK Cav-3 preconditioning (SF-PreCon)–mediated cardioprotection their precise underlying action remain incompletely understood. Methods Results— SF-PreCon (consisting 3 cycles 15-minute exposure 2% before 30 minutes MI) decreased MI/R in...
It has been argued that metabolically healthy obesity (MHO) does not increase cardiovascular disease (CVD) risk. This study examines the association of MHO with carotid intima-media thickness (cIMT), a proxy CVD risk, in children and adolescents.Data were available for 3,497 adolescents aged 6-17 years from five population-based cross-sectional studies Brazil, China, Greece, Italy, Spain. Weight status categories (normal, overweight, obese) defined using BMI cutoffs International Obesity...
Autophagy is a key regulatory process in maintaining cellular homoeostasis via lysosome degradation. Growing evidence reveals that poly(ADP-ribose) polymerase-1 (PARP1) involved the progression of many cardiovascular diseases. This study was undertaken to discuss role PARP1 cardiomyocyte autophagy. Our results demonstrated activated response starvation-induced myocardial We identified Forkhead box O (FoxO)3a as substrate PARP1. Upon activation, poly(ADP-ribosyl)ation dissociated histone H1...
Cu-Ni-Co-Si alloys have been regarded as a candidate for the next-generation integrated circuits. Nevertheless, using trial and error method to design high-performance copper requires lot of effort time. Thus, material based on machine learning is used accelerate exploitation alloys. In this study, composition-process-property database was established, new strategy that could simultaneously realize prediction properties optimization compositions process parameters proposed. Four groups were...
Diabetic retinopathy (DR) is a severe complication of chronic diabetes. The C1q/TNF-related protein family (CTRPs) has been demonstrated to exert protective effects against obesity and atherosclerosis in animal studies. Heretofore, the association between circulating CTRPs DR patients unexplored. In current study, we attempt define this association, as well effect upon pathophysiology.The present investigation case control study that enrolled subjects type 2 diabetes mellitus (T2DM)...
The cardioprotective effects of adiponectin (APN) against myocardial ischemia/reperfusion (MI/R) injury are well known. However, comprehension the mechanisms mediating intracellular APN signaling remains incomplete. We recently demonstrate antioxidant/antinitrative not dependent on AMPK. Protein kinase A (PKA) has been previously shown to be activated by APN, with uncertain relevance cardiac protection. current study determined whether antioxidative/antinitrative effect is mediated PKA....
The transcription factor Sp1 is implicated in the activation of G0/G1 phase genes. Modulation activities may affect G1-S checkpoint, resulting changes cell proliferation. In this study, our results demonstrated that activated poly(ADP-ribose) polymerase 1 (PARP-1) promoted proliferation by inhibiting signaling pathway. Cell and cycle assays PARP inhibitors or PARP-1 siRNA treatment significantly inhibited hepatoma cells induced arrest cells, while overexpression activator progression....
Abstract Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic sevoflurane (SF-PreCon) remains cardioprotective during and identified the involved mechanisms. Normal diet (ND) high-fat (HFD)-induced DM mice were randomized into...
Pressure–temperature‐coupling‐induced structural transition and thermal properties of Al 3 TM (TM = Ti, Zr, Hf) have been studied using the first‐principles calculations combined with quasi‐harmonic approximation. The enthalpy indicates that transitions to L12 structure at a specific pressure threshold ( for Hf). fundamental thermodynamic parameters, including equilibrium volume , expansion coefficient α heat capacity do not abruptly change due transition. Whereas many elastic properties,...
On-demand droplet jetting can be achieved through the axial reciprocating motion of jet tube, which is a novel technology. However, its feasibility for high-frequency has not been explored. In this study, it found that when driving signals are applied to piezoelectric ceramic, tube undergoes forced vibration, enables repeatable at frequencies up 10 kHz. This paper also investigates effects vibration amplitude and frequency on behavior reveals linear relationship between velocity amplitude.
This study is to investigate the factors that influence functional autonomy outcomes in children who have undergone rehabilitation for spinal cord injury. The aim enhance clinical guidance provided inpatients at China Rehabilitation Research Center, Beijing Bo-ai Hospital. Furthermore, objective optimize interventions and establish a scientific basis. employed retrospective survey method data collection analysis. Descriptive analysis, one-way ANOVA Multiple logistic regression analysis were...
Current drop-on-demand metal jetting technologies provide precise control over the start and stop of jetting, as well exact number droplets ejected. However, these methods are generally constrained by low frequencies. Conversely, continuous can achieve significantly higher frequencies but lack capability to precisely regulate droplets. To address limitations existing droplet techniques, this study introduces a novel high-frequency jet-on-demand approach utilizing forced vibration jet tube....
To determine the patterns and influencing factors of mechanical properties millet stems from different varieties during maturity period, this study employed a complete block experiment method conducted shearing bending tests on using INSTRON5544 electronic universal material testing machine. The research investigated variation in shear strength, specific energy, elastic modulus, stiffness at internode positions Changza 466, Zhangza 16, Jingu 21 their period. results indicated that variety...
This study determines the roles of tumor necrosis factor-α (TNFα) and lymphotoxin-α (LTα) in post-myocardial infarction (post-MI) cardiac injury, identifies TNF receptor type responsible for TNFα- LTα-mediated injury.Adult male wild (WT), TNFα(-/-), LTα(-/-), TNFR1(-/-), TNFR2(-/-) mice were subjected to MI via coronary artery occlusion. Functional, histological, biochemical analyses performed 1 7 days post-MI. In WT mice, significantly increased both TNFα LTα levels plasma, but distinct...