A5101464989- Nutrition and Health in Aging
- Frailty in Older Adults
- Air Quality and Health Impacts
- Influenza Virus Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Pneumonia and Respiratory Infections
- Blood Pressure and Hypertension Studies
- Gastric Cancer Management and Outcomes
- Health disparities and outcomes
- Chronic Disease Management Strategies
- Climate Change and Health Impacts
- Health, Environment, Cognitive Aging
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Metabolism, Diabetes, and Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Air Quality Monitoring and Forecasting
- Corneal surgery and disorders
- Diabetes Management and Education
- Physical Activity and Health
- Obesity, Physical Activity, Diet
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Huashan Hospital
2020-2025
Fudan University
2015-2025
Weihai Municipal Hospital
2025
Shandong University
2025
Qilu Hospital of Shandong University
2025
Genesee Community College
2025
Zhejiang University of Technology
2025
Shanghai Municipal Center For Disease Control Prevention
2006-2024
Shanghai Jiao Tong University
2022-2024
Cardiovascular disease (CVD) is one of the leading causes death worldwide. Our study aimed to investigate prevalence two conditions, angina and stroke, relevant risk factors among older adults in six low- middle- income countries(LMICs).The data was from World Health Organization (WHO) Study on global AGEing adult (SAGE) Wave 1 China, Ghana, India, Mexico, Russian Federation South Africa. Presence CVD based self-report stroke. Multivariate logistic regression performed examine relationship...
Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), has been approved for EGFR-mutant non-small-cell lung cancer (NSCLC). We aimed to evaluate the efficacy and safety of neoadjuvant osimertinib in patients with resectable locally advanced NSCLC.This single-arm, phase 2b trial (ChiCTR1800016948) was conducted at six centers mainland China. Patients measurable stage IIA-IIIB (T3-4 N2) adenocarcinoma EGFR exon 19 and/or 21 mutations were...
Abstract Background China's socioeconomic and population structures have evolved markedly during the past few decades, consequently, monitoring prevalence of Parkinson's disease (PD) is crucial. Objective This study aimed to investigate PD within Chinese communities, particularly in older people. Methods A nationwide 24,117 participants, aged 60 years or older, was carried out 2015 using multistage clustered sampling. All participants were initially screened a nine‐item questionnaire, from...
OBJECTIVE Diabetes presenting at a younger age has more aggressive nature. We aimed to explore the association of type 2 diabetes mellitus (T2DM) diagnosis with subsequent cancer incidence in large Chinese population. RESEARCH DESIGN AND METHODS The prospective population-based longitudinal cohort included 428,568 newly diagnosed T2DM patients from 2011 2018. Participants were divided into six groups according their diagnosis: 20–54, 55–59, 60–64, 65–69, 70–74, and ≥75 years. overall 14...
Background: Little is known about the adverse effects of frailty transitions. In this study, we aimed to characterize transitions between states and examine their associations with type death among older adults in China, a developing country rapidly growing aging population. Methods: We used data 11,165 (aged 65–99 years) from 2002 2005 waves Chinese Longitudinal Healthy Longevity Survey (CLHLS). Overall, 44 health deficits were construct index (FI; range: 0–1), which was then categorized...
Abstract Background Anemia and frailty contribute to poor health outcomes in older adults; however, most current research lower income countries has concentrated on anemia or alone rather than combination. The aim of the present study was investigate association between community-dwelling adults aged 50 years China. Methods population sourced from 2007/10 SAGE China Wave 1. defined as hemoglobin less 13 g/dL for men 12 women. A Frailty Index (FI) compiled assess frailty. evaluated using a...
Abstract Background It is important to clarify the transitions and related factors of frailty for prevention frailty. We evaluated among community-dwelling older adults examined predictors transitions. Methods A cohort study was conducted 3988 community residents aged ≥60 years during 2015 2017. multiple deficits approach used construct Frailty Index (FI) according methodology FI construction, sociodemographic characteristics lifestyles were also collected in 2015. After 2-year follow-up,...
Abstract Background COVID-19 lockdowns may lead to physical inactivity, a major risk factor for non-communicable diseases. This study aims determine: 1) the trajectory in daily step counts before, during and after lockdown China, 2) characteristics associated with trajectories. Methods From December 2019 July 2020, smartphone-based were continuously collected 815 Chinese adults residing Shanghai over 202 days across three phases: during, lockdown. Participant reported, height, weight body...
Adults with chronic conditions such as heart disease, diabetes, or lung disease are more likely to develop complications from a number of vaccine-preventable diseases, including influenza and pneumonia. In this study, we use the data management information system in Shanghai estimate vaccination coverage characterize predictors seasonal 23-valent pneumococcal polysaccharide vaccine (PPSV23) among people Shanghai.The Centers for Disease Control Prevention have systems related management,...
The ovarian cancer (OC) follow-up study (OOPS) is an on-going hospital-based large prospective longitudinal cohort aimed to explore the relationship between pre/post-diagnostic biological, clinical, environmental, and lifestyle factors with focus on diet OC prognosis (including drug resistance, relapse, mortality). Patients recruited during baseline survey were 18 79 years old, histologically confirmed diagnosis. Their medical treatment conducted at gynecological oncology ward Shengjing...
The associations of long-term exposure to air pollutants in the presence asthmatic symptoms remain inconclusive and joint effects as a mixture are unclear.We aimed investigate individual ambient fine particulate matter (PM2.5) daily 8-hour maximum ozone concentrations (MDA8 O3) Chinese adults.Data were derived from World Health Organization Study on Global Ageing Adult (WHO SAGE) cohort study among adults aged 50 years or older, which was implemented 1 municipality 7 provinces across China...
In the absence of an effective treatment to alter progressive course cognitive decline and dementia, identification modifiable risk factors that could promote healthy aging has become a public health research priority. This study seeks comprehensively determine contemporaneous associations broad spectrum time-varying lifestyle with age-related in large population-based cohort older adults. A total 5711 subjects aged 50 from WHO Study on global AGEing adult (SAGE) Shanghai were studied....
A series of studies have explored the health effects long-term exposure to ambient PM2.5 among older adults. However, few investigated adverse effect on frailty, and results are inconclusive. This study sought investigate associations between frailty in 6 low- middle-income countries.
Abstract Clear cell carcinoma (CCC), endometrioid (EC), and serous (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis still unclear. Here, we undertake comprehensive proteomic profiling 80 CCC, 79 EC, SC, 30 control samples. Our analysis reveals prognostic or diagnostic value dysregulated proteins phosphorylation sites important pathways. Moreover, protein co-expression network not only provides view biological features each...
Background: The increasing prevalence of myopia among Chinese children and adolescents, especially at younger ages, has emerged as a significant concern in recent years. Pre-myopia is key period for prevention control adolescents. Previous studies suggested auricular acupressure (AA) therapy might offer viable approach to prevent slow down progression. Nonetheless, these lack robust, high-quality, large-scale, multi-center evidence conclusively support such assertions. purpose this research...
The aim of this study was to develop and validate a deep learning radiomics (DLR) model based on longitudinal ultrasound data clinical features predict pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer patients. Between January 2018 June 2023, 312 patients with histologically confirmed were enrolled randomly assigned training cohort (n = 219) test 93) 7:3 ratio. Next, pre-NAC post-treatment 2-cycle images collected, extracted from NAC pre-treatment...
Epidermal growth factor receptor (EGFR) exon 19 insertions (19ins) represent a unique subclass of alterations that has relatively low frequency. Here, we aimed to elucidate the molecular characteristics and response EGFR tyrosine kinase inhibitors (EGFR-TKIs) in lung cancer patients with 19ins. Next-generation sequencing was performed profile 83 non-small cell (NSCLC) Detailed profiling efficacy analyses were on these patients, comparisons 68 deletion (19del) patients. Potential resistance...
Abstract Acquired resistance to epidermal growth factor receptor-tyrosine-kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, is a critical obstacle in the treatment of EGFR mutant-positive non-small cell lung cancer (NSCLC). EHD1, protein C-terminal Eps15 homology domain-containing (EHD) family, plays role regulating endocytic recycling, but mechanistic details involved EGFR-TKI stemness remain largely unclear. Here, we found that lower EHD1 expression improved both EGFR-TKIs...