A5100379708- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- Drug Transport and Resistance Mechanisms
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Pancreatitis Pathology and Treatment
- Bipolar Disorder and Treatment
- Gastric Cancer Management and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Breast Cancer Treatment Studies
- Renal Diseases and Glomerulopathies
- Cancer Treatment and Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- MicroRNA in disease regulation
- Liver Diseases and Immunity
- Advanced Neuroimaging Techniques and Applications
- Inflammatory Bowel Disease
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Infectious Encephalopathies and Encephalitis
Zhengzhou University
2023-2025
Shantou University
2014-2024
First Affiliated Hospital of Shantou University Medical College
2021-2024
Taizhou People's Hospital
2023-2024
Nanjing Medical University
2024
Nantong University
2024
Chongqing Medical University
2024
Shandong University
2023
Qingdao University
2019-2023
Yuhuangding Hospital
2023
The prevalence of obesity is increasing worldwide and significantly affects fertility reproduction in both men women. Our recent study has shown that excess body fat accelerates ovarian follicle development loss rats. aim the present to explore effect SIRT1 activator SRT1720 on reserve pool lifespan obese mice underlying mechanism associated with mTOR signaling. Adult female Kunming (n = 36) were randomly divided into three groups: normal control (NC) group 8), caloric restriction (CR) (fed...
Inflammatory bowel disease (IBD) represents a prominent chronic immune-mediated inflammatory disorder, yet its etiology remains poorly comprehended, encompassing intricate interactions between genetics, immunity, and the gut microbiome. This study uncovers novel colitis-associated risk gene, namely Ring1a, which regulates mucosal immune response intestinal microbiota. Ring1a deficiency exacerbates colitis by impairing system. Concomitantly, led to Prevotella genus-dominated pathogenic...
BACKGROUND:Acute respiratory distress syndrome (ARDS), which is characterized by severe hypoxemia (PaO2/FIO2 ≤300 mmHg), usually companied uncontrolled inflammation, oxidative injury, and the damage to alveolar-capillary barrier. Severe ARDS with acute lung injury that worsen patients' condition. HIPK1 a modulator of homeodomain-containing transcription factors regulates multiple cellular biological process associated inflammation anti-stress responses. MATERIAL AND METHODS:We used an...
Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting characterized by chronic inflammation in the gastrointestinal tract. The exact etiology pathogenesis of IBD remain elusive. Although ELF-1 has been known to be highly expressed epithelial cells for past twenty years, little about its function epithelial-related IBD. Here, we demonstrated that deficiency mouse lead exacerbated DSS-induced colitis, marked dominated neutrophil infiltration activation IL-17 signaling...
Abstract Acquired resistance to epidermal growth factor receptor-tyrosine-kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, is a critical obstacle in the treatment of EGFR mutant-positive non-small cell lung cancer (NSCLC). EHD1, protein C-terminal Eps15 homology domain-containing (EHD) family, plays role regulating endocytic recycling, but mechanistic details involved EGFR-TKI stemness remain largely unclear. Here, we found that lower EHD1 expression improved both EGFR-TKIs...
Sorafenib is a multi-kinase blocker and one of the few suggested drug treatments for aggressive hepatocellular carcinoma (HCC) patients. However, resistance to sorafenib may often occur over time cause further tumor aggression. Recently, cancer stem cells were found in HCC speculated be involved progression. SOX9 highly expressed promotes cell proliferation self-renewal. Meanwhile, patients with higher expression show poorer prognosis. Whether still unclear. Here, we that treatment increased...
Carbapenem resistance is rarely reported in
The deep learning convolution neural network (DL-CNN) benefits evaluating clot burden of acute pulmonary thromboembolism (APE). Our objective was to compare the performance trained by fine-tuning [DL-CNN (ft)] and from scratch (fs)] in quantitative assessment APE.We included data 680 cases for training DL-CNN (ft) (fs), then retrospectively 410 patients (137 with APE, 203 males, mean age 60.3±11.4 years) testing models. distribution volume clots were respectively assessed DL-CNN(ft)...
Kidney renal clear cell carcinoma (KIRC), with low survival rate, is the most frequent subtype of carcinoma. Recently, more and studies indicate that cuproptosis-related genes (CRGs) long non-coding RNAs (lncRNAs) play a vital role in occurrence development many types cancers. However, roles lncRNAs (CRlncRNAs) KIRC was uncertain.
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease, and its pathogenesis not fully understood. Our previous study discovered that receptor interacting protein kinase 3 (RIP3) correlated with serum transaminase levels in AIH patients. However, role underlying mechanism are poorly Here, we detected the increased expression activation of RIP3 livers patients animal models AIH. The inhibition by GSK872 prevented concanavalin A (ConA)-induced (IMH) reduced hepatic...
Abstract Recent research underscores the significance of nervous system in tumor progression. Nonetheless, understanding intricate roles nerves gastric tumorigenesis remains limited. Our study aims to elucidate nerve alterations, associated key genes, and signaling pathways during tumorigenesis. We enroll 257 patients with precancerous lesions (GPLs) from four national cohorts. Utilizing immunohistochemistry digital analysis, we quantified densities sympathetic parasympathetic nerves, as...
Development of specific serum biomarkers is essential to improve diagnosis and prognosis non-small cell lung cancer (NSCLC).Here, we show that tissue levels miR-519d are significantly decreased in NSCLC patients.The low expression associated with lymph node metastases, clinical stage, a poor patients.In addition, ROC analysis demonstrated the can distinguish patients from healthy controls.MiR-519d inhibits proliferation, migration, invasion by cells, indicating it may function as tumor...
Gastric cancer (GC) is one of the most common and lethal cancers worldwide. The Nudix hydroxylase (NUDT) genes have been reported to play notable roles in tumor progression. However, role NUDT10 GC has not reported. In this study, we investigated expression its association with clinicopathological characteristics. Quantitative real-time polymerase chain reaction analyses Cancer Genome Atlas Human Protein databases were performed determine mRNA protein expression. Receiver operating...
ARMCX1 (Armadillo repeat containing X-linked 1) is identified to be the novel tumor suppressor gene related multiple types. Nonetheless, its effect on gastric cancer (GC) still poorly understood. The present work determined level within GC and relation with clinicopathological characteristics. This also collected relevant information in Cancer Genome Atlas (TCGA) database for investigating associations of clinicopathologic variables then validated our cohort. Receiver operating...
Immune-inflammatory response plays a key role in the pathogenesis of atherosclerosis. IgG N-glycosylation is reported to be associated with 10-year atherosclerotic cardiovascular disease risk score and subclinical However, relationship glycosylation actual clinical (CVD) events plaque phenotypes has rarely been investigated. Therefore, this study aims understand whether traits are correlated CVD phenotypes. Designed verify efficacy as for screen potential biomarkers prevent atherosclerosis...
Abstract Background: Programmed death-1 (PD-1) pathway inhibition has demonstrated clinical activity in breast cancer (BC), with modest response rate advanced, heavily pretreated, hormone receptor positive (HR+), human epidermal growth factor 2 negative (HER2−) BC. Cyclin-dependent kinase 4/6 (CDK 4/6) coupled estrogen (ER) signaling blockade is an efficient treatment approach for patients metastatic HR+/HER2− BC, evaluated the primary setting. Preclinical data suggest potential synergistic...
TPS1105 Background: Cyclin-dependent kinase 4/6 (CDK 4/6) inhibition coupled with ER signaling blockade is an efficient treatment approach for patients (pts) metastatic hormone receptor-positive, HER2− BC. Preclinical data suggest synergistic activity of CDK and PD-1 blockade; in a syngeneic mouse tumor model, improved efficacy complete regression were observed phased administration ABE + PD-L1 therapy. Methods: CheckMate 7A8 (NCT04075604) randomized, noncomparative, multicenter, phase 2...
To investigate ESI-MS/MS fragmentation pattern of bile acids contained in Qingkailing injection, and the rapid identification method.HPLC-ESI-MS/MS technology was adopted to five rapidly identify injection from eight different manufacturers.5 showed similar patterns, based on which 14 were separated injection. Among them, 11 found injections all manufacturers, rest three individual manufacturers.HPLC-ESI-MS/MS is used complex material systems, provides an effective method for interpreting...