A5102139349- Marine Sponges and Natural Products
- Seaweed-derived Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Synthetic Organic Chemistry Methods
- Advanced Cellulose Research Studies
- Marine Toxins and Detection Methods
- Algal biology and biofuel production
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Plant Toxicity and Pharmacological Properties
- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Medicinal Plants
- Nanocomposite Films for Food Packaging
- Heavy Metals in Plants
- Medicinal plant effects and applications
- Organic Electronics and Photovoltaics
- Bioactive Natural Diterpenoids Research
- Magnetic and Electromagnetic Effects
- Gout, Hyperuricemia, Uric Acid
- Diatoms and Algae Research
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Bioactivity Studies
- Bioactive Compounds in Plants
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Dalian Polytechnic University
2024
Xi'an Jiaotong University
2023
Nationwide Children's Hospital
2023
Wenzhou Medical University
2008-2016
China Medical University
2008
Shenyang Pharmaceutical University
2008
Achieving high short-circuit current density (JSC) to boost power conversion efficiency (PCE) of all-polymer solar cells (all-PSCs) is a major challenge, mainly due the difficultly in developing high-performance near-infrared (NIR)-absorbing polymer acceptors. Herein, new acceptor named PY2Se-4F employing Y-series small-molecule as precursor designed and synthesized. Thanks its unique molecular backbone structure combining selenophene-fused central core bi-fluorinated end-group, shows...
Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (1), unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (2), new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (3), and two cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (4) (S)-4-hydroxy-5-methylene-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (5), were isolated from a South China Sea...
Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation three new α-methylene-γ-lactone-containing cembranoids, (1R*,3R*, 4R*,14R*,7E,11E)-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide (1), (1R*,7S*,14S*,3E, 11E)-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (2), and (1R*,7S*,14S*, 3E,11E)-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide (3), along with eleven known analogues 4–14. The structures compounds were elucidated...
Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the compounds elucidated by extensive spectroscopic analysis and comparison data reported in literature. All evaluated for their cytotoxicity against selected cancer cell lines inhibition lipopolysaccharide (LPS)-induced nitric oxide (NO) production mouse peritoneal macrophages.
Four new xenicanes, namely 4α-hydroxyisodictyohemiacetal (1), 4α-hydroxyisodictyoacetal (2), 13,18-diacetoxy-4-hydroxyisodictyo-19-al (3), and 4α-hydroxypachylactone (8), were isolated from a Chinese collection of the brown alga Dictyota plectens, along with four known analogues (4–7). The structures diterpenes determined by extensive spectroscopic data analysis. All compounds evaluated for their antiviral activities against human immunodeficiency virus type 1 (HIV-1) highly pathogenic avian...
Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures compounds determined by extensive spectroscopic analysis comparison previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring...
Twenty-seven diterpenes of six chemical classes, including seven new (1, 2, 6, 10, 11, 16, and 19), have been isolated from a collection the brown alga Dictyota plectens South China Sea. The structures were elucidated by extensive spectroscopic analysis comparison with reported data. In in vitro assays, 9, 12, 14, 22 showed inhibitory activity against HIV-1 replication IC50 values 16.1–30.5 μM, compounds 5, 13, 24, 26 exhibited anti-H5N1 inhibition rates 50%–62% at 30.0 12 24 also potent...
Gelsemine from Gelsemium elegans Benth is a potential anesthetic and analgesic agent with no physical dependence opiate addiction. This study was aimed at developing an ultrafast liquid chromatography coupled to tandem mass spectrometry method quantify gelsemine in rat plasma tissues. Plasma tissues were processed acetonitrile precipitation, dendrobine chosen as the internal standard. Sample separation performed on ACQUITY HSS T3 column. The mobile phase consisted of 0.1% formic acid aqueous...
The effects of five ginsenosides (G-Rh2, -Rd, -Rb1, -Rb2, -Rh1) isolated from the root Panax gingseng on stimulus-induced superoxide generation in human neutrophils were evaluated by measuring reduction ferricytochrome c. tyrosyl or serine/threonine phosphorylation neutrophil proteins and translocation p47phox, p67phox, Rac to plasma membrane detected using specific monoclonal antibodies. G-Rh2 significantly suppressed induced N-formylmethionyl-leucylphenylalanine (fMLP), phorbol...
Several ferulic acid ethyl esters (3a–h) were synthesized under the Knoevengel reaction condition and they further reduced to afford respective allylic alcohol derivatives (4a–g). Some of them evaluated for xanthine oxidase (XO) inhibitory activity. Among them, 3h exhibited a significant activity with an IC50 value 1.35 × 10−5 M, while allopurinol used as positive control was 1.49 M. The study suggested that higher acidity phenolic OH group in might result improved XO
Four new 7,8-epoxycembranoids, namely (2S*,7S*,8S*,12R*,1Z,3E,10E)-7,8:2,16-diepoxycembra-1(15),3,10-trien-12-ol (1), (2S*,7S*,8S*,11R*,1Z,3E)-7,8:2,16-diepoxycembra-1(15),3,12(20)-trien-11-ol (2), (4S*,7S*,8S*,1Z,2E,11E)-16-acetoxy-7,8-epoxycembra-1(15),2,11-trien-4-ol (3), and (7S*,8S*,15S*,1E,3E,11E)-7,8-epoxycembra-1,3,11-trien-15,16-diol (4) were isolated from a Chinese soft coral Lobophytum sp., together with eleven known analogues 5-15. The structures of the compounds determined by...
A phytochemical investigation of the roots Ligularia atroviolacea resulted in isolation 24 compounds including seven new eremophilanoids named eremophila-3,7(11),8-triene-12,8;14,6alpha-diolide (1), 3beta-(angeloyloxy)eremophil-7(11)-en-12,8beta-olid-14-oic acid (2), 1alpha-chloro-10beta-hydroxy-6beta-(2-methylpropanoyloxy)-9-oxo-7,8-furoeremophilane (3), (10betaH)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic (4), (10alphaH)-8-oxoeremophila-3(4),6(7)-diene-12,14-dioic (5),...
Abstract isolation, structural elucidation and inhibitory effect on lipopolysaccharide (LPS)‐induced nitric oxide (NO) production in mouse peritoneal macrophages
Four new xenicanes (I)—(III) are isolated along with four known analogues and evaluated for their bioactivity.