A5101465578- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Heart Failure Treatment and Management
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Medical research and treatments
- Gallbladder and Bile Duct Disorders
- Cancer Mechanisms and Therapy
- Multiple and Secondary Primary Cancers
Chinese PLA General Hospital
2019-2025
Fujian Medical University
2024
Intrahepatic cholangiocarcinoma (ICC), a type of bile duct cancer, has high mortality rate. Gut microbiota, acid (BA) metabolism, and cytokines have not been characterized in patients with ICC, better noninvasive diagnostic approaches for ICC are essential to be established. Therefore, this study we aimed improve our understanding changes gut BA ICC. We found that the α-diversities β-diversities were highest abundances four genera (Lactobacillus, Actinomyces, Peptostreptococcaceae,...
Abstract Molecular targeted agents, such as sorafenib, remain the only choice of an antitumor drug for treatment advanced hepatocellular carcinoma (HCC). The Notch signaling pathway plays central roles in regulating cellular injury/stress response, anti-apoptosis, or epithelial–mesenchymal transition process HCC cells, and is a promising target enhancing sensitivity cells to agents. ADAM metalloprotease domain-17 (ADAM-17) mediates cleavage activation protein. In present study, microRNA-3163...
This study aimed to analyze the clinical characteristics and potential predictors of disease severity in patients with coronavirus 2019 (COVID-19). We retrospectively analyzed data from 64 (37 male 27 female) COVID-19. Their mean age was 47.8 years; 43 (67.2%) cases were non-severe, 21 (32.8%) severe, 2 (3.1%) died. Age serum ferritin levels significantly associated COVID-19 severity. There no significant differences duration severe illness or number days on high-level respiratory support...
Chronic hepatitis B and cirrhosis pose significant global health threats. Few studies have explored the disease burden mortality trend of caused by virus infection among adolescents young adults (AYAs, aged 15-39 years). This study aimed to assess trends. Publicly available data were obtained from 2021 GBD database. The rates incidence, mortality, disability-adjusted life years calculated at global, regional, national levels. Temporal trends assessed using joinpoint regression analysis,...
INTRODUCTION: Chronic liver inflammation leads to fibrosis, cirrhosis and hepatocellular carcinoma. Serum alanine aminotransferase is the most widely used indicator of inflammatory injury, but it does not accurately reflect extent chronic inflammation. The role exosomes in fibrosis has gained significant interest. This study aimed investigate association between serum exosome-derived miRNAs injury hepatitis B (CHB) patients with evaluate their potential clinical value. METHODS: Using samples...
e16215 Background: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited efficacy of second-line treatment following intolerance or failure first-line therapy. This study aimed to explore the efficacy, safety, and effectiveness-related biological characteristics adebrelimab combined lenvatinib as regimen in patients advanced ICC. Methods: single-arm, open-label phase II enrolled unresectable metastatic ICC who had experienced progression chemotherapy....
Background Involvements of microRNA-22 (miR-22) in cancer have attracted much attention, but its role diagnosis hepatocellular carcinoma (HCC) is still largely unknown. Therefore, the aim this study was to investigate expression level and prognostic value miR-22 HCC patients.Methods Quantitative real-time polymerase chain reaction (qRT-PCR) performed evaluate serum 108 patients 67 healthy controls. The relationship between clinicopathologic characteristics analysed via chi-square test....
Background Serum amyloid A1 (SAA1) is an acute-phase protein involved in acute or chronic hepatitis. Its function still controversial. In addition, the effect of expression SAA1 and its molecular on progression hepatocellular carcinoma (HCC) unclear. Aim To demonstrate prognosis HCC explain further correlation immunity pathways. Methods was conducted with The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) GEPIA tool, survival analysis based level achieved Kaplan-Meier portal....
Immunotherapy combined with VEGF inhibitor has become the new first-line therapy for advanced or metastatic hepatocellular carcinoma (HCC). However, biomarkers response and prognosis stratification of HCC immunotherapy have not been clarified.Here, we obtained genomic alteration data from pre-therapeutic samples 103 patients using a 605-gene NGS test, transcriptional T cell receptor (TCR) diversity 18 who underwent RNAseq TCR sequencing, respectively. Patients received sorafenib/sintilimab...
Long non coding RNAs (lncRNAs) are important in the occurrence and development of various cancers. They have been considered to participate many processes diseases. In this study, we aimed at investigating expression level clinical significance lncRNA X91348 hepatocellular carcinoma (HCC). The tissue serum samples from patients with HCC healthy people was detected through quantitative real-time polymerase chain reaction (qRT-PCR). decreased compared controls no matter or samples....
Dysregulation in lipid metabolism contributes to the occurrence and development of various cancers. The connection between changes intrahepatic cholangiocarcinoma remains uncertain. Our objective was investigate significance blood levels patients with who have undergone surgery.
We explore the dose-efficacy relationship of lenvatinib plus anti-PD-1 in patients with unresectable hepatocellular carcinoma (u-HCC) infected hepatitis B virus (HBV) real-world practice. Furthermore, we identify population sensitive to treatments.This retrospective study included 70 treated at least 3 cycles and 140 alone. Stabilized inverse probability treatment weighting (SIPTW) was used balance clinical features between two groups. The overall survival (OS), progression-free (PFS),...
Introduction Dysregulation in lipid metabolism contributes to the occurrence and development of various cancers. The relationship between changes intrahepatic cholangiocarcinoma (ICC) pathogenesis is yet unclear. We aimed explore role serum levels ICC patients that underwent surgery.Methods retrospectively enrolled 97 surgery. After 92.2 months follow-up, Kaplan-Meier analysis Cox proportional hazard model were used calculate overall survival (OS) recurrence-free (RFS).Results median age...
54 Background: Hepatocellular carcinoma (HCC) is characterized by hypovascularity, the efficacy of transcatheter arterial chemoembolization (TACE) has been suboptimal. This study sought to evaluate and compare safety profiles cryoablation (CRYO) plus lenvatinib (LEN) against TACE LEN for unresectable hepatocellular (u-HCC) patients within a real-world clinical practice. Methods: A prospective was conducted involving 234 with u-HCC who underwent treatment either CRYO or at Fifth Medical...
e16152 Background: To assess the efficacy and safety of lenvatinib plus anti-PD-1 versus alone in patients with unresectable hepatocellular carcinoma (u-HCC) explore characteristics benefit population for combination therapy. Methods: This retrospective study included 70 u-HCC that were treated 140 Fifth Medical Center Chinese PLA General Hospital Electric Power Beijing from November 2017 to February 2021. Clinical features balanced by stabilized inverse probability treatment weighting...
Hepatocellular carcinoma (HCC) is the major cause of malignancy-related deaths worldwide, and its incidence likely to increase in future as life expectancy increases. Therefore, management elderly patients with HCC has become a global issue. Aim this study was assess whether small could obtain survival benefit from cryoablation (CRYO) real-world.From July 2007 June 2013, 185 who underwent curative-intent percutaneous CRYO. All were divided into three groups according age distribution....
e16151 Background: Targeted therapy is the most effective therapeutic approach for middle and late-stage hepatocellular carcinoma (HCC). Regorafenib or PD-1 as a second-line treatment of patients with advanced HCC has achieved good results. Argon-helium cryoablation one commonly used method local ablation liver cancer. Whether systemic combined can benefit cancer hot topic. This study aimed to investigate efficacy safety regorafenib in after failure targeted treatment. Methods: In this...