A5033013455- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Metabolism, Diabetes, and Cancer
- Alcohol Consumption and Health Effects
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Gallbladder and Bile Duct Disorders
- Vascular Malformations and Hemangiomas
- Genetic and Kidney Cyst Diseases
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
Affiliated Hospital of Southwest Medical University
2018-2025
Southwest Medical University
2008-2025
Inner Mongolia Electric Power (China)
2024
Second Military Medical University
2023
Eastern Hepatobiliary Surgery Hospital
2023
Central South University
2023
First Affiliated Hospital of Sichuan Medical University
2008-2021
Showa University
2015
Southern Medical University
2012-2013
Nanfang Hospital
2012-2013
Abstract Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC essential for the development novel therapeutics. Here, we constructed two independent cohorts from clinic centers. A comprehensive multiomics analysis via proteomic, whole-exome sequencing (WES), single-cell RNA (scRNA-seq) was performed. Novel subtypes were derived in training cohort (n =...
Colorectal cancer (CRC) is a common malignancy involving multiple cellular components. The CRC tumor microenvironment (TME) has been characterized well at single-cell resolution. However, spatial interaction map of the TME still elusive. Here, we integrate multiomics analyses and establish to improve prognosis, prediction, therapeutic development for CRC. We construct immune module (CCIM) that comprises FOLR2+ macrophages, exhausted CD8+ T cells, tolerant CD4+ regulatory cells. Multiplex...
In this study, kaempferol (KA) ameliorates APAP-induced hepatotoxicity by activating HO-1/NQO1 and inhibiting HMGB1/TLR4/NF-κB signaling NLRP3 inflammasome activation.
Scope While probiotics‐based therapies have exhibited potential in alleviating alcohol‐associated liver disease (ALD), the specific role of postbiotics derived from Lactobacillus reuteri ( L. ) ALD remains elusive. This study aims to investigate impact on ameliorating alcohol‐induced hepatic steatosis and underlying mechanisms. Methods results Using network pharmacology, elucidates targets pathways impacted by , identifying farnesoid X receptor (FXR) as a promising target for against ALD,...
Background . Aloin exerts considerable protective effects in various disease models, and its effect on hepatic ischemia-reperfusion (HIR) injury remains unknown. This research is aimed at conducting an in-depth investigation of the antioxidant, anti-inflammatory, antiapoptosis aloin HIR explain underlying molecular mechanisms. Methods In vivo , different concentrations were intraperitoneally injected 1 h before establishment model male mice. The function, pathological status, oxidative...
Currently, many nutritional indicators, including controlling status score (CONUT), can be used to assess a patient's and have been reported as reliable predictors of multiple malignancies. However, the value CONUT in predicting postoperative outcomes patients with hilar cholangiocarcinoma has not explored. In this study, its predictive will discussed compared known neutrophil lymphocyte ratio (NLR) prognostic index (PNI).Preoperative scores, PNI NLR levels 94 Hilar (HCCA) who underwent...
Long non-coding RNAs (lncRNAs) play a significant role in multiple human cancers as competing endogenous (ceRNAs). However, systematic mRNA-microRNA (miRNA)-lncRNA network linked to kidney renal clear cell carcinoma (KIRC) prognosis has not been described. In this study, we aimed identify the prognosis-related ceRNA regulatory and analyzed its relationship with immune infiltration predict KIRC patient survival. The MMP25-AS1/hsa-miR-10a-5p/SERPINE1 related of was obtained through...
Inducible nitric oxide synthase (iNOS) and vascular endothelial dysfunction have been implicated in the development progression of atherosclerosis. This study aimed to elucidate role iNOS dysfunction. Ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry combined with multivariate data analysis was used characterize metabolic changes human umbilical vein cells (HUVECs) response different treatment conditions. In addition, molecular biology techniques were...
Disorders of lipid oxidation play an important role in organ damage, and metabolites are associated with inflammation coagulation dysfunction sepsis. However, the specific molecular mechanism by which metabolism-related proteins regulate sepsis is still unclear. The aim this study to investigate mortality factor 4-like protein 1 (MORF4L1, also called MRG15), a hepatic metabolism related gene, sepsis-induced liver injury.
The purpose of this study is to investigate the protective effect kaempferol (KAE), main active monomer from Penthorum chinense Pursh, on hepatic ischemia/reperfusion injury (HI/RI) and its specific mechanism. HI/RI a common complication closely related prognosis liver surgery, effective prevention treatment methods are still unavailable. Ischemia/reperfusion (I/R) caused by tissue damage during ischemia sustained oxidative stress inflammation reperfusion. Pursh traditional Chinese medicine...
Objectives To investigate the expression and role of Cathepsin L (CTSL) in Hepatocellular carcinoma (HCC) tissue cell line (MHCC-97H), to evaluate clinical prognostic significance CTSL protein patients with HCC. Methods The was examined HCC MHCC-97H cells by Western-blotting, Real-time PCR immunohistochemical staining. Cell growth curve assay colony formation were used verify effect on proliferation tumor progression ability cells. Tumor nude mice analyze tumorigenicity Results status...
Nonalcoholic fatty liver disease (NAFLD) is a common chronic associated with high levels of serum uric acid (SUA). However, whether this relationship applies in obese subjects has been unclear, and no cohort study previously conducted non-obese subjects. We therefore performed retrospective among employees seven companies China to investigate hyperuricemia was independently NAFLD subjects, respectively. A total 2383 initially NAFLD-free were followed up for four years, 15.2% (363/2383)...
Alcoholic liver disease (ALD), a type of chronic that is prevalent worldwide, still identified to have poor prognosis despite many medical treatment protocols. Thus, it urgent develop and test new protocols for ALD. Lactobacillus reuteri (L. reuteri) has been widely used in the clinical digestive system diseases, but studies on protective effect L. ALD are considered be rare. Therefore, present study, we examined provide data significant development An model established C57BL/6J mice treated...
Alcoholic liver disease (ALD) is caused by alcohol abuse and can progress to hepatitis, cirrhosis, even hepatocellular carcinoma. Previous studies suggested that Lactobacillus reuteri (L. reuteri) ameliorates ALD, but the exact mechanisms are not fully known. This study created an ALD model in mice, results showed L. significantly alleviating lipid accumulation mice. Transcriptome sequencing treatment group had most enriched metabolic pathway genes. We then studied farnesoid X receptor (FXR)...
Background and Aims: NASH has emerged as a leading cause of chronic liver disease. However, the mechanisms that govern fibrosis remain largely unknown. CREBZF is CREB/ATF bZIP transcription factor causes hepatic steatosis metabolic defects in obesity. Approach Results: Here, we show key mechanism checkpoint promotes hepatocyte injury exacerbates diet-induced mice. deficiency attenuated injury, fibrosis, inflammation mouse models NASH. increases HSC activation hepatocyte-autonomous manner by...
Background: Nonalcoholic steatohepatitis (NASH) has recently garnered increased attention due to immune infiltration.However, the role of membrane-associated protein 17 (MAP17) in NASH remains unclear, which prompted this study explore its relationship with infiltration and regulatory mechanisms.Methods: We employed weighted correlation network analysis (WGCNA) construct a gene co-expression aimed at identifying key genes associated progression.Our further analyses included differential...
Abstract Compound C, a well‐known inhibitor of AMP‐activated protein kinase (AMPK), has been reported to exert antitumor activities in some types cells. Whether compound C can effects human cholangiocarcinoma (CCA) remains unknown. Here, we demonstrated that is potent inducer cell death and autophagy CCA Autophagy inhibitors increased the cytotoxicity towards cells, as confirmed by LDH release, PARP cleavage. It notable treatment phosphorylated Akt, sustained high levels p70S6K, decreased...
Despite the epidemiological association between intrahepatic cholangiocarcinoma (ICC) and hepatitis B virus (HBV) infection, little is known about relevant oncogenic effects. A cohort of 32 HBV-infected ICC 89 non-HBV-ICC patients were characterized using whole-exome sequencing, proteomic analysis, single-cell RNA sequencing. Proteomic analysis revealed decreased cell-cell junction levels in HBV-ICC patients. The level had an inverse relationship with epithelial-mesenchymal transition (EMT)...