A5060850674- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- Fullerene Chemistry and Applications
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
- Bipolar Disorder and Treatment
- Pharmacological Receptor Mechanisms and Effects
- Lung Cancer Treatments and Mutations
- HIV/AIDS drug development and treatment
- Fluoride Effects and Removal
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Diagnosis and Treatment
- Graphene research and applications
- Exercise and Physiological Responses
National Clinical Research Center for Digestive Diseases
2022-2025
First Affiliated Hospital Zhejiang University
2022-2025
Yunnan Agricultural University
2025
Zhejiang University
2022-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2022-2024
National Clinical Research
2022
Gansu Agricultural University
2013
National Center for Nanoscience and Technology
2011-2012
Peking Union Medical College Hospital
2010
Chinese Academy of Medical Sciences & Peking Union Medical College
2010
Abstract Tryptophan (Trp) metabolism plays a crucial role in influencing the development of digestive system tumors. Dysregulation Trp and its metabolites has been identified various cancers, including esophageal, gastric, liver, colorectal, pancreatic cancers. Aberrantly expressed are associated with diverse clinical features Moreover, levels these can serve as prognostic indicators predictors recurrence risk patients exert their influence on tumor growth metastasis through multiple...
Abstract Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC essential for the development novel therapeutics. Here, we constructed two independent cohorts from clinic centers. A comprehensive multiomics analysis via proteomic, whole-exome sequencing (WES), single-cell RNA (scRNA-seq) was performed. Novel subtypes were derived in training cohort (n =...
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Intratumoral bacteria might play essential roles in tumorigenesis different cancer types. However, its features and potential hepatocellular carcinoma (HCC) are largely unknown.
Aims: [Gd@C82(OH)22]n is a new type of nanoparticle with potent antineoplastic activity and low toxicity compared traditional drugs. In this study, we explored, for the first time, effect on cell cycle using human breast cancer MCF-7 umbilical vein endothelial ECV304 lines by flow cytometry. Methods: Cell viability was assessed through CCK-8 assay, tumor-bearing mice were examined after 2 weeks treatment [Gd@C82(OH)22]n. cycle-related gene expression detected microarray confirmed real-time...
Abstract Kynurenine derivative 3‐hydroxyanthranilic acid (3‐HAA) is known to regulate the immune system and exhibit anti‐inflammatory activity by inhibiting T‐cell cytokine secretion influencing macrophage activity. However, definite role of 3‐HAA in immunomodulation hepatocellular carcinoma (HCC) largely unexplored. An orthotopic HCC model treated with intraperitoneal injection developed. Furthermore, cytometry time‐of‐flight (CyTOF) single‐cell RNA sequencing (scRNA‐seq) analyses are...
Multi-hydroxylated endohedral metallofullerenol [Gd@C82(OH)22]n nanoparticles possess the general physico-chemical characteristics of most nanoparticles. They also exhibit uniquely low toxicity and antineoplastic efficacy. In current study, molecular mechanisms epigenetic action these are explored. Human breast cancer MCF-7 human umbilical vein endothelial ECV304 cell lines were used. Cell viability assay, hierarchical cluster analysis by cDNA microarray, semi-quantitative reverse...
Hepatocellular carcinoma remains the third most common cause of cancer-related deaths worldwide. Although great achievements have been made in resection, chemical therapies and immunotherapies, pathogenesis mechanism HCC initiation progression still need further exploration. Necroptosis genes reported to play an important role malignant activities, thus it is importance comprehensively explore necroptosis-associated HCC.We chose LIHC cohort from TCGA, ICGC GEO databases for this study....
L-tryptophan (Trp) metabolism involved in mediating tumour development and immune suppression. However, comprehensive analysis of the role Trp pathway is still a challenge.We downloaded metabolism-related genes' expression data from different public databases, including TCGA, Gene Expression Omnibus (GEO) Hepatocellular Carcinoma Database (HCCDB). And we identified two metabolic phenotypes using ConsensusClusterPlus package. Univariate regression lasso Cox were used to establish risk model....
Leptospirosis poses a major threat to human life. The disease spectrum ranges from nearly undetectable presentation severe multi-organ dysfunction and death. is difficult diagnose by traditional antibody culture tests. We here present case of multiple organ failure associated with leptospirosis.A 64-year-old woman presented fatigue arthralgia, which developed rapidly into injuries, she eventually died cerebral hemorrhage. Serum test cultures blood, sputum, urine, feces samples were all...
Red clover (Trifolium pratense L.) as a dietary supplement is currently used to treat menopausal symptoms because of its high concentrations mildly estrogenic isoflavone.The application rate N and P fertilizer has huge influence on the isoflavone content (IC) in red clover.Trifolium 'Minshan' unique plant resource alpine pasture region northwest China.It plays very important role livestock production pharmaceutical industry nutritional value IC.To date, little information exists selection...
Objectives. There are no detailed reports on the long-term outcome of patients treated with tenofovir disoproxil fumarate (TDF) compared entecavir (ENT) following liver transplantation. We aimed to assess association between TDF use and recipients using ENT. Methods. This retrospective observational study included who underwent transplantation January 2015 May 2019 at First Affiliated Hospital Zhejiang University School Medicine Hangzhou Shulan Hospital. Cox regression, propensity score...
Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and poor prognoses around the world. Within-cell polarity crucial to cell development function maintenance, some studies have found that it closely related cancer initiation, metastasis, prognosis. The aim of our research was find polarity-related biomarkers which improve treatment prognosis HCC. For knowledge-driven analysis, 189 genes (PRGs) were retrieved curated manually from molecular signatures database...