A5089367351- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Fullerene Chemistry and Applications
- Immunotherapy and Immune Responses
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Graphene research and applications
- Elasticity and Wave Propagation
- Context-Aware Activity Recognition Systems
- Thermoelastic and Magnetoelastic Phenomena
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Thermography and Photoacoustic Techniques
- Pharmacological Effects of Natural Compounds
- Nanocluster Synthesis and Applications
- RNA modifications and cancer
- CAR-T cell therapy research
- Cancer-related gene regulation
- Muscle activation and electromyography studies
- Advanced biosensing and bioanalysis techniques
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Porphyrin and Phthalocyanine Chemistry
- Cancer Cells and Metastasis
Hebei University of Science and Technology
2016-2024
Shijiazhuang University
2017
University of Pittsburgh
2013
National Center for Nanoscience and Technology
2010-2012
Hebei Normal University
2010
Chinese Academy of Sciences
2010
Chinese University of Hong Kong
2009
Cisplatin is a chemotherapeutic drug commonly used in clinics. However, acquired resistance confines its application chemotherapeutics. To overcome the to cisplatin, it reasoned, based on our previous findings of mediation cellular responses by [Gd@C 82 (OH) 22 ] n nanoparticles, that may reverse tumor cisplatin reactivating impaired endocytosis cisplatin-resistant human prostate cancer (CP-r) cells. Here we report exposure CP-r PC-3-luc cells presence nontoxic not only decreased number...
Aims: [Gd@C82(OH)22]n is a new type of nanoparticle with potent antineoplastic activity and low toxicity compared traditional drugs. In this study, we explored, for the first time, effect on cell cycle using human breast cancer MCF-7 umbilical vein endothelial ECV304 lines by flow cytometry. Methods: Cell viability was assessed through CCK-8 assay, tumor-bearing mice were examined after 2 weeks treatment [Gd@C82(OH)22]n. cycle-related gene expression detected microarray confirmed real-time...
The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon liver lung cancer. Camptothecin-based drugs inhibit topoisomerase 1 (Topo 1), leading to destruction DNA, are currently being used as important chemotherapeutic agents clinical treatment. However, the main obstacle associated with cancer therapy is represented by systemic toxicity conventional anticancer their low accumulation at tumor site. In addition, bioavailability, poor...
Serine/arginine-rich (SR) proteins are a family of important splicing factors, which involved in multiple aspects RNA processing, including splicing, mRNA nuclear export, stability and translation. Previous studies have identified number SR that exhibit abnormal expression various tumor types. In the present study, function serine/arginine-rich factor 7 (SRSF7) were investigated colon lung cancer. Using tissue immunohistochemistry, it was observed SRSF7 overexpressed cancer tissues. As role...
Lithium–sulfur (Li–S) batteries are promising energy storage systems owing to their high theoretical density and low costs due the abundant reserves of sulfur.
Multi-hydroxylated endohedral metallofullerenol [Gd@C82(OH)22]n nanoparticles possess the general physico-chemical characteristics of most nanoparticles. They also exhibit uniquely low toxicity and antineoplastic efficacy. In current study, molecular mechanisms epigenetic action these are explored. Human breast cancer MCF-7 human umbilical vein endothelial ECV304 cell lines were used. Cell viability assay, hierarchical cluster analysis by cDNA microarray, semi-quantitative reverse...
An important research area in computer vision is developing algorithms that can reconstruct the 3D surface of an object represented by a single 2D line drawing. Previous work on reconstruction from drawings focuses objects with planar faces. In this paper, we propose novel approach to solid have not only but also curved Our consists four steps: (1) identifying faces and drawing, (2) transforming drawing into one straight edges only, (3) reconstructing wireframe transformed original (4)...
RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering (siRNA) delivery system limits its clinical application. Here, we report bioreducible less-cationic siRNA carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable nanomedicines coordination between zinc ions DPA the anionic phosphate siRNA....
Tumor immunotherapy represented by immune target blocking and chimeric antigen receptor cell therapy has developed rapidly. Among them, Natural Killer Cell (NK) is gradually becoming another preferred method after T because of its unique killing effect in innate immunity adaptive immunity. Although NK achieved promising results clinical trials, there are still some problems, such as low efficacy solid tumors, insufficient penetration cells high cost treatment. Nanomaterials expected to be an...
The prognosis for cancer patients has declined dramatically in recent years due to the challenges treating malignant tumors. Tumor immunotherapy, which includes immune target inhibition and chimeric antigen receptor cell treatment, is currently evolving quickly. Among them, natural killer (NK) cells are gradually becoming another preferred immunotherapy after T their unique killing effects innate adaptive immunity. NK therapy shown encouraging outcomes clinical studies; however, there still...
Hydraulic drive system of exoskeleton intelligent load carry robot is founded in this paper firstly. And then, a hydraulic position feedback control loop established using human-machine coupling method. Furthermore, designed based on PI and lead correction network combination methods. Finally, performance the tested under different walking condition oil source pressure. Experimental results show that can achieve actuator precision servo when wearing human walks with heavy load.
The combination of antiangiogenesis with chemotherapy has become a promising multi-modal combinational therapy for solid tumor. However, hypoxia-mediated resistance and the subsequent treatment failure associated have limited maximization this approach. It remains major challenge to balance effect angiogenesis accumulation cytotoxic drug within tumor microenvironment. In study, we report nanotechnology based delivery solution that would improve both antiangiogenic activity efficacy loaded...
A lagging response in time exists between the propagation of heat flux and establishment temperature gradient it is affected by space effect during conduction with micro-scale property. Based on general law thermal mass, dynamic model generalized thermoelasticity established Clausius inequality Helmholtz free energy, where inertia involved. The guiding equations are derived given for isotropic homogeneous materials. By comparison existing models thermoelasticity, can reduce to L-S, G-L G-N...
Serine threonine tyrosine kinase 1 (STYK1)/novel oncogene with domain (NOK) has been demonstrated to promote cell carcinogenesis and tumorigenesis, as well strengthen cellular aerobic glycolysis, which is considered be a defining hallmark of cancer. As the carriers glucose into cells, transporters (GLUTs) are important participants in metabolism even tumorigenesis. However, best our knowledge, role GLUTs biological events caused by STYK1/NOK not yet reported. The present study assessed GLUT3...
The inertia effect induced by the motion of heat flow will have a significant impact on transfer, when pulse duration or device structure has micro-scale characteristics. Based thermomass theory, thermal wave equation is introduced to describe thermomass, and generalized thermoelastic dynamic model involved in established combining constitutive relation isotropic material. By taking into account characteristics for transient one-dimensional problem semi-infinite solid with boundary subject...
The consumption of large amounts ethanol can directly lead to acute gastric mucosal bleeding, edema, and erosion, while long-term drinking has been associated with ulcers. Previous research demonstrated that Har Gabur, a traditional Mongolian medicine, alleviates ulcers through the physical adsorption its carbon components. It is well known immune response an important role in ulceration.In present study, we used ethanol-induced injury cell mice model investigate whether Gabur inhibit...
Macrophages are important immune effector cells with significant plasticity and heterogeneity in the body system, play an role normal physiological conditions process of inflammation. It has been found that macrophage polarization involves a variety cytokines is key link regulation. Targeting macrophages by nanoparticles certain impact on occurrence development diseases. Due to its characteristics, iron oxide have used as medium carrier for cancer diagnosis treatment, making full use special...