A5076894795- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Fish Biology and Ecology Studies
- Photoacoustic and Ultrasonic Imaging
- Advanced Glycation End Products research
- Aquaculture disease management and microbiota
- Photodynamic Therapy Research Studies
- Drug Transport and Resistance Mechanisms
- Parasite Biology and Host Interactions
- Graphene and Nanomaterials Applications
- Biochemical Analysis and Sensing Techniques
- ATP Synthase and ATPases Research
- Systemic Lupus Erythematosus Research
- Metal complexes synthesis and properties
- Cancer Treatment and Pharmacology
- Identification and Quantification in Food
- Adenosine and Purinergic Signaling
- Cholesterol and Lipid Metabolism
- melanin and skin pigmentation
- Chemotherapy-induced organ toxicity mitigation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Lipids, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Curcumin's Biomedical Applications
- Quantum Dots Synthesis And Properties
Suez Canal University
2022-2024
National Center for Nanoscience and Technology
2016-2022
University of Chinese Academy of Sciences
2016-2022
Chinese Academy of Sciences
2016-2022
State Key Laboratory of Respiratory Disease
2018-2019
Second Affiliated Hospital of Guangzhou Medical University
2018-2019
Guangzhou Medical University
2018-2019
Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability pharmacokinetic complexity remain major obstacles to clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" that possess intrinsic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) synergistic...
Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Despite considerable advances in clinical treatment RA, suboptimal response to therapy and discontinuation are still unresolved challenges due systemic toxicity. It crucial importance actively target deliver therapeutic agents inflamed joints order promote situ activity decrease In this study, we found that SPARC (secreted protein acidic rich cysteine) was overexpressed synovial fluid synovium RA patients as...
The adaptive treatment tolerance (ATT) of cancer cells is the main encumbrance to chemotherapy. A potential solution this problem treat with multiple drugs using nanoparticles (NPs). In study, we tested co-administration curcumin (Cur) and doxorubicin (Dox) MCF-7 resistant breast block ATT elicit efficient cell killing. Drugs were co-administered both sequentially simultaneously. Sequential drug was carried out by pre-treating albumin (ANPs) loaded Cur (Cur@ANPs) followed Dox-loaded ANPs...
Vitamin E derivatives possess many essential features for drug-delivery applications, such as biocompatibility, stability, improvement of water solubility hydrophobic compounds, anticancer activity, and the ability to overcome multidrug resistance (MDR). Herein, vitamin are used MDR through a combined P-glycoprotein (P-gp) inhibition mitochondrial impairment strategy. A novel nanomicellar system carrier doxorubicin (DOX) was developed, in which d-α-tocopheryl polyethylene glycol 1000...
Amyloodiniosis and vibriosis are serious diseases in European seabass (Dicentrarchus labrax) hatcheries with noticeable high mortality. This study was conducted on tank-cultured D. labrax frys at a private marine hatchery near Mariout Lake (Alexandria, Egypt). Frys showed mortality rate (70%), lethargy, darkening, asphyxia, ascites, velvety skin appearance. Both infectious agents were presumptively identified all investigated frys. The identities of the two recovered confirmed by molecular...
Nile tilapia is the most farmed freshwater fish species across vast areas of African continent. Although Egypt considered largest producer tilapia, this has been faced with frequent episodes mortality at both hatchery and farm levels. In present study, we conducted field screenings to identify major bacterial pathogens responsible for these mass kills among broodstocks seeds in Egyptian hatcheries. Aeromonas hydrophila Streptococcus agalactiae were determined be threats hatchery-reared...
Suboptimal intratumor accumulation and poorly controllable release of encapsulated drugs remain unresolved challenges hampering further advancement nanomedicines in cancer therapy. Herein, we conceived near-infrared (NIR) laser-triggered transformable BiS@HSA/DTX multiple nanorods (mNRs), which were made small bundles bismuth sulfide (BiS NRs) coated with docetaxel (DTX)-inlaid human serum albumin (HSA). The mNRs had a lateral size approximately 100 nm efficiently accumulated the tumor...
The combination of antiangiogenesis with chemotherapy has become a promising multi-modal combinational therapy for solid tumor. However, hypoxia-mediated resistance and the subsequent treatment failure associated have limited maximization this approach. It remains major challenge to balance effect angiogenesis accumulation cytotoxic drug within tumor microenvironment. In study, we report nanotechnology based delivery solution that would improve both antiangiogenic activity efficacy loaded...
Abstract Among the most typical reasons of end-stage renal disease (ESRD) is diabetic nephropathy (DN), which also rated as a major microvascular complication diabetes mellitus. The existent study looked at impact dapagliflozin, mulberry fruit and leaves extracts their combination on kidney rats. To induce nephropathy, experimental rats were supplied with 10% fructose (Fr) in drinking water for first two weeks. Each Fr-fed animal received an intraperitoneal injection low single dose STZ (40...
Aspartame is a common artificial sweetener that thought to be dangerous.On the other hand, stevioside (stevia) natural of plant origin was assumed alternative sweeteners.This study aimed determine whether aspartame or affected biochemical, sero-biochemical, and immunohistochemical changes in adult rats following six weeks exposure.Forty-eight were used divided into three groups: Group I: control group, II: received (75 mg/kg/day), III: (45 mg/kg/day).All medications given orally for 6...
Drug targeting is a promising strategy for efficient treatment of various serious diseases such as cancer. The primary goal this concept to provide precise delivery therapeutic agents into pathological area, while 384avoiding negative impact onto healthy tissues. Through approach, high efficacy the drug can be attained experiencing minimum side effects. Recently, nano-sized carriers have received great attention systems which load, bring, and release drugs in localized area. Accurate...