A5053985678- Epigenetics and DNA Methylation
- Zebrafish Biomedical Research Applications
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Mosquito-borne diseases and control
- RNA modifications and cancer
- Pancreatic function and diabetes
- Histone Deacetylase Inhibitors Research
- Hydrogen's biological and therapeutic effects
- Malaria Research and Control
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Osteoarthritis Treatment and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Medical and Biological Ozone Research
- Pancreatic and Hepatic Oncology Research
- Insect symbiosis and bacterial influences
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
University of Copenhagen
2023-2025
Rigshospitalet
2023-2025
National Taiwan Ocean University
2025
Copenhagen University Hospital
2024
Singapore-MIT Alliance for Research and Technology
2021-2023
National Taiwan University Hospital
2023
Hudson Institute
2023
University of Nebraska Medical Center
2023
National University of Singapore
2017-2022
National Taiwan University
2014-2022
The mosquito-borne Chikungunya virus (CHIKV) is a profound global threat due to its high rate of contagion and the lack vaccine or effective treatment. Suramin symmetric polyanionic naphthylurea that widely used in clinical treatment parasite infections. Numerous studies have reported broad antiviral activities suramin; however, inhibition effects against CHIKV not yet been demonstrated. aim this study was thus investigate effect suramin on infection elucidate molecular mechanism underlying...
Hepatocarcinogenesis commonly involves the gradual progression from hepatitis to fibrosis and cirrhosis, ultimately hepatocellular carcinoma (HCC). Endothelin 1 (Edn1) has been identified as a gene that is significantly up-regulated in HBx-induced HCC mice. In this study, we further investigated role of edn1 hepatocarcinogenesis using transgenic zebrafish model cell culture system. Liver-specific expression caused steatosis, fibrosis, glycogen accumulation, bile duct dilation, hyperplasia,...
Genistein is an isoflavone extracted from soybean (Glycine max). This compound has anti-inflammatory, anti-oxidative, and anti-cancer effects; however, the mechanism underlying effects of genistein on IL-1β-stimulated human osteoarthritis (OA) chondrocytes remains unknown. Our objectives in this study were to explore anti-inflammatory OA investigate potential mechanisms which underlie them. results in-vitro model indicate that inhibits IL-1β-induced expression catabolic factors nitric oxide...
ABSTRACT Dengue fever is a widespread viral infectious disease transmitted by mosquitoes. Despite the potentially fatal consequences for some individuals, no antiviral drugs have been approved treatment of this disease. Taiwan's National Health Insurance Database (NHID) holds extensive medical records almost every resident, encompassing conventional and traditional Chinese medicine (TCM) treatments. This study aims to uncover potential TCM formulas with properties against dengue analyzing...
Aberrant histone methylation is a frequent event during tumor development and progression. KMT1E (also known as SETDB1) H3K9 methyltransferase that contributes to epigenetic silencing of both oncogenes suppressor genes in cancer cells. In this report, we demonstrate acts metastasis strongly downregulated highly metastatic lung Restoring expression setting suppressed filopodia formation, migration, invasive behavior. Conversely, loss cells with limited potential promoted migration vitro...
Hepatocarcinogenesis is a multistep process that starts from fatty liver and transitions to fibrosis and, finally, into cancer. Many etiological factors, including hepatitis B virus X antigen (HBx) p53 mutations, have been implicated in hepatocarcinogenesis. However, potential synergistic effects between these two factors the underlying mechanisms by which they promote hepatocarcinogenesis are still unclear. In this report, we show action of HBx mutation triggers progressive hepatocellular...
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the deterioration of articular cartilage. The progression OA leads to an increase in inflammatory mediators joints, thereby promoting destruction cartilage matrix. Recent studies have reported on anti-inflammatory and antioxidant properties cardamonin, which also appears interact with cellular targets, such as nuclear erythroid 2-related factor 2 (Nrf2), extracellular signal-regulated kinase (ERK), mammalian target...
Hepatitis B virus X antigen plays an important role in the development of human hepatocellular carcinoma (HCC). The key regulators controlling temporal downstream gene expression for HCC progression remains unknown. In this study, we took advantage systems biology approach and analyzed microarray data HBx transgenic mouse as a screening process to identify differentially expressed genes applied software Pathway Studio potential pathways involved HCC. Using subnetwork enrichment analysis,...
The deregulated nonoxidative pentose phosphate pathway (PPP) is known to promote oncogenesis, but the molecular mechanism remains unknown. Here, we report that human ribose-5-phosphate isomerase A (RPIA) plays a role in hepatocellular carcinoma (HCC). significant increase RPIA expression was detected both tumor biopsies of HCC patients and liver cancer tissue array. Importantly, clinicopathological analysis indicated mRNA levels were highly correlated with clinical stage, grade, size, types,...
The WNK1 (WNK lysine deficient protein kinase 1) is a serine/threonine with emerging roles in cancer. causes hypertension and hyperkalemia when overexpressed cardiovascular defects ablated mice. In this study, the role of Wnk1 angiogenesis was explored using zebrafish model. There are two wnk1 isoforms, wnk1a wnk1b, both contain all functional domains found human protein. Both isoforms expressed embryo at initiation posterior cardinal vein (PCV), similar to fms-related tyrosine 4 (flt4)....
Tumor hypoxia is a hallmark of solid tumors and emerged as the therapeutic target for cancer treatments, such prodrug Tirapazamine (TPZ) activated in hypoxia. To increase tumor accumulation, gold nanoparticles (GNPs) were selected to conjugate with TPZ. In this study, we successfully formulated assessed biochemical roles conjugated nanoparticles-Tirapazamine (GNPs-TPZ) on assessments MKN45-induced xenograft animal model. The results indicated that GNPs-TPZ was potential nanomedicine...
Altered metabolism is one of the hallmarks cancers. Deregulation ribose-5-phosphate isomerase A (RPIA) in pentose phosphate pathway (PPP) known to promote tumorigenesis liver, lung, and breast tissues. Yet, molecular mechanism RPIA-mediated colorectal cancer (CRC) unknown. Our study demonstrates a noncanonical function RPIA CRC. Data from mRNAs 80 patients' CRC tissues paired nontumor protein levels, as well tissue array, indicate significantly elevated modulates cell proliferation...
Background/Aim: Regulatory T cells (Treg) play a crucial role in maintaining immune tolerance and preventing autoimmune diseases. Recent data also indicate that type 1 regulatory (Tr1) B (Breg) an inhibitory (i.e., protective) Conventional synthetic disease-modifying antirheumatic drugs (csDMARD) are first-line therapy for rheumatoid arthritis (RA), our aim was to predict clinical responses of this treatment using immunophenotyping. Materials Methods: We first detected the presence fresh...
The SOX4 transcription factor is a key regulator of embryonic development, cell-fate decision, cellular differentiation and oncogenesis. Abnormal expression related to malignant tumor transformation cancer metastasis. However, no reports are available regarding the clinical significance in acute myeloid leukemia (AML) role leukemogenesis. In current study, we found that AML patients with low bone marrow (BM) had higher remission rates longer overall survival than those high expression,...
α-1,2 mannosidases, key enzymes in N-glycosylation, are required for the formation of mature glycoproteins eukaryotes. Aberrant regulation mannosidases can result cancer, although underlying mechanisms unclear. Here, we report distinct roles mannosidase subtypes (MAN1A, MAN1B, ERMAN1, MAN1C) hepatocellular carcinoma (HCC). Clinicopathological analyses revealed that clinical stage, tumor size, α-fetoprotein level, and invasion status were positively correlated with expression levels MAN1A1,...