This retrospective cohort study aimed to examine the relationship between herpes zoster ophthalmicus (HZO) and subsequent risk of dementia using a population-based database. We retrieved sample from Taiwan Longitudinal Health Insurance Database 2005. The group included 846 patients with HZO, comparison 2538 without HZO. Each patient was individually followed for 5-year period identify those who subsequently received diagnosis dementia. performed Cox proportional hazards regression calculate...

ABSTRACT Dengue fever is a widespread viral infectious disease transmitted by mosquitoes. Despite the potentially fatal consequences for some individuals, no antiviral drugs have been approved treatment of this disease. Taiwan's National Health Insurance Database (NHID) holds extensive medical records almost every resident, encompassing conventional and traditional Chinese medicine (TCM) treatments. This study aims to uncover potential TCM formulas with properties against dengue analyzing...

Androgen deprivation therapy (ADT) has been the standard treatment for advanced prostate cancer many decades. Although potential adverse effects of ADT have reported, there are no empirical studies investigating association between and Alzheimer's disease. Therefore, this retrospective cohort study explored relationship use subsequent risk disease in men with using a population-based database. We retrieved data from "Taiwan Longitudinal Health Insurance Database 2000." The included 1335...

Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few explored association subsequent acute infection. This retrospective cohort study aimed to compare risk of pneumonia subjects with those without psoriasis.

Sleep disturbances are among the most common nonmotor symptoms of Parkinson disease. However, no large epidemiological data regarding association between obstructive sleep apnea (OSA) and disease have been reported. The goal this study was to investigate risk for during a 5-y follow-up period after diagnosis OSA using population-based dataset.The retrospective longitudinal cohort were retrieved from Taiwan Longitudinal Health Insurance Database 2000. We identified 1,532 patients with as...

The main purpose of this study was to investigate the transmembrane permeability polyphenol-containing Polygonum cuspidatum extracts (PCE) encapsulated in phospholipid-based o/w microemulsion system. First, preparations several PCEs using solid- or liquid-phase extraction a combination both, as well evaluation their antioxidant activities, were conducted and compared. In study, results indicated that PC-1 with least process exhibited best activity. By comparing coefficient (K(p)) among all...

Objective Although obstructive sleep apnea (OSA) is not a life-threatening disease, very few studies have compared differences in healthcare service utilization between patients with and those without OSA an Asian population according to different age groups. This study attempted investigate groups Taiwan. Methods Sampled subjects data on their health were retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included 568 2840 OSA. Each subject was followed for 1-year...

Prior studies suggested that the use of androgen deprivation therapy (ADT) in patients with prostate cancer (PC) might cause impairment cognitive function which is one common symptoms dementia; however, association between ADT and still remains controversial. This retrospective cohort study aimed to investigate relationship subsequent risk dementia using a population-based dataset. Data for this were taken from Taiwan (China)Longitudinal Health Insurance Database 2005. We included 755 PC who...

Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings the relationship between and RA remain inconsistent. Furthermore, all such were conducted in Western societies, relevant on Asian countries are still lacking. In this study, we investigated subsequent risk using population-based dataset. We retrieved data for retrospective cohort study from Taiwan "Longitudinal Health Insurance Database 2005". included 4,294 subjects who...

Some of the prior literature investigated potential association between rheumatoid arthritis (RA) and Alzheimer's disease (AD) because these two diseases may share similar inflammatory mechanisms. Nevertheless, to date, findings previous are still controversial, some methodological limitations were observed in those studies. The aim this case-control study was investigate relationship RA AD using a large population-based dataset. This used Taiwan Longitudinal Health Insurance Database 2005....

The relationship between obstructive sleep apnea (OSA) and chronic rhinosinusitis (CRS) still remains unclear. This retrospective cohort study aimed to investigate the OSA subsequent CRS using a population-based dataset. used data from Taiwan Longitudinal Health Insurance Database 2005. We selected 971 patients with for 4855 without comparison cohort. Each patient was tracked 5 years determine those who were subsequently diagnosed CRS. Stratified Cox proportional hazard regression analyses...

Many researchers have expected pioglitazone to serve as an effective neuroprotective agent against Parkinson's disease (PD). Therefore, we conducted this cohort study investigate the association between use and PD by using a large Asian population-based dataset in Taiwan.Retrospective study.Taiwan.7906 patients with diabetes who had received were defined cohort, 7906 matched not comparison cohort.We tracked each patient individually over 5-year follow-up period identify those diagnosed...

Sodium-glucose cotransporter-2 inhibitors (SGLT2i), a novel class of antidiabetic medications, have emerged as key treatment option for diabetes management. Notably, SGLT2i promote glucose and sodium excretion through urine, mechanism that may be implicated in the potential association between use atopic dermatitis (AD) risk. This study investigated relationship new-onset AD diabetic patients. nationwide active-comparator cohort utilized data from Taiwan National Health Insurance Database to...

Palliative care is underutilized for severely ill patients with advanced chronic obstructive pulmonary disease (COPD) experiencing significant symptoms during hospitalization. The impact of mechanical ventilation on inpatient palliative utilization remains largely unexplored. In this study, we aimed to investigate among hospitalized COPD requiring and examine the associated risk factors clinical outcomes. A retrospective nested case-control study was conducted using population-based claims...

Abstract Background Hormonal therapy (HT) is widely administered for contraception and menopausal symptom management. However, its impact on psoriasis risk remains unclear, requiring an evaluation across diverse age groups to inform clinical practice optimize treatment strategies. Objective To investigate the association between HT of in reproductive-age postmenopausal women. Methods This study utilized both nationwide cohort design target trial emulation, analyzing data from Taiwan's...

Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between and risk of subsequently being diagnosed with disorder (DD) during 3-year follow-up period. The patient sample for this population-based, retrospective cohort was retrieved from Taiwan Longitudinal Health Insurance Database 2005. We included all 1714 patients aged over 40 years first-time diagnosis prostate...

Degradation of the M phase cyclins triggers exit from phase. Cdc14 is major phosphatase required for One functions to dephosphorylate and activate Cdh1/APC/C complex, resulting in degradation cyclins. However, other crucial targets mitosis cytokinesis remain be elucidated. Here we systematically analyzed positions dephosphorylation sites budding yeast Saccharomyces cerevisiae. Quantitative mass spectrometry identified a total 835 on 455 potential substrates vivo. We validated two events,...

Background Some studies suggested that psychological stress may be associated with the severity and duration of infectious diseases. In this population-based study, we investigated associations between depressive disorder (DD) pneumonia outcomes in Taiwan a large-scale database from National Health Insurance. Methods Our study defined 112,198 patients who were hospitalized principal diagnosis pneumonia. We their admission date for treatment as index date. Subsequently, selected 2,394 DD...