shao m.‐f., chou y.‐c., yeh m.‐y. & tzeng w.‐c. (2010) Sleep quality and of life in female shift‐working nurses. Journal Advanced Nursing 66 (7), 1565–1572. Abstract Title. Aim. This paper is a report study the factors that influence sleep among nurses relationship between their life. Background. Although strive to adapt schedules shift rotations, they tend suffer from severe disturbances increased rates cancer, cardiovascular diseases, digestive disease irregular menstrual cycles. Poor...

Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction 7 genes, included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRP1, 5), SRY-box 1 (SOX1), paired box gene (PAX1) and LIM homeobox transcription factor alpha (LMX1A) primary tumor samples from 126 patients with ovarian cancer, 75 benign 14 borderline malignancy an tumor, 26...

Drug resistance is an obstacle to the treatment of ovarian cancer. Using a unique cell model, we have proven previously that subpopulation cancer cells more resistant cisplatin than are original cells. MicroRNAs (miRNAs), small noncoding RNAs, involved in many biological events In our study, explored whether miRNAs Cisplatin-resistant expressed lower level miR-29a/b/c. Manipulation microRNA-29 (miR-29) expression modulated sensitivity CP70, HeyC2, SKOV3 and A2780 Knockdown miR-29a/b/c...

<b><i>Background:</i></b> Chronic periodontitis and gingivitis are associated with various diseases; however, their impact on dementia is yet to be elucidated. This study aimed at investigating the association between chronic gingivitis, risk of developing dementia. <b><i>Methods:</i></b> A total 2,207 patients, newly diagnosed January 1, 2000 December 31, 2000, were selected from National Health Insurance Research Database Taiwan, along 6,621...

To explore the associations between different dietary patterns and semen quality in a general Asian male population.Cross-sectional study. Healthy Taiwanese men aged 18 years or older who participated standard medical screening program from 2008-2013 run by private firm were included this Semen parameters including sperm concentration (SC), total motility (TSM), progressive (PRM) normal morphology (NSM) recorded. A questionnaire was used to categorize participants into 5 groups: "Healthy...

This study aimed to explore the association between body mass index (BMI), other anthropometric indexes and semen quality in a general male population Taiwan. In this cross-sectional cohort study, consisted of 7941 healthy individuals aged 18 years or older who participated standard medical screening program run by private firm from January 2008 May 2013. Semen parameters including sperm concentration (SC), total motility (TSM), progressive (PRM), normal morphology (NSM) were recorded....

Allergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these risk of developing overall disorders in patients from Taiwan.This cohort used database Taiwan National Health Insurance Program. A total 186,588 enrolled patients, 46,647 subjects who had suffered 139,941...

The increasing prevalence of metabolic syndrome (MetS) has become an important issue worldwide. Metabolic comorbidities hypertension, obesity, and hyperlipidemia are shown as risk factors for incident gout. purpose this study was to investigate the relationship between hyperuricemia MetS. This is a cross-sectional study. effective sample included 21,544 individuals who received worker health examinations at local teaching hospital in Changhua County from 2008~2012. We used multiple logistic...

Abstract Metastatic prostate cancer continues to pose a difficult therapeutic challenge. Prostate progression is associated with aberrant O-glycosylation of cell surface receptors, but the functional impact such events uncertain. Here we report spontaneous metastasis human xenografts that express high levels galectin-4 along genetic signatures EGFR-HER2 signaling and O-glycosylation. Galectin-4 expression in clinical specimens correlated poor patient survival. binding multiple receptor...

Recent studies demonstrated the utility of perineural injection with platelet-rich plasma (PRP) and 5% dextrose (D5W) as novel strategies for treatment carpal tunnel syndrome (CTS). The present study comprised a prospective, randomized, single-blind, head-to head comparative trial to compare 6-month outcome PRP or D5W in patients moderate CTS. Fifty-two unilateral CTS were enrolled randomized into two groups: group received single 3-cc under ultrasound guidance, guidance. Boston Carpal...

Abstract Most proton pump inhibitors (PPIs) inhibit the bioactivation of clopidogrel to its active metabolite. There is controversy concerning whether PPIs alter effectiveness in reducing risk ischemic stroke (IS). We therefore aimed examine IS associated with concomitant use and omeprazole, a PPI commonly used clinical settings. conducted retrospective cohort study using National Health Insurance Research Database Taiwan dated from 2000 2013. The cohorts comprised 407 patients diagnosed...

Adiponectin is a peptide hormone secreted exclusively by adipocytes, and obesity an established risk factor for breast cancer. We have, thus, evaluated the associations of anthropometric measures adiposity adiponectin with development cancer in case–control study. Questionnaire information, measures, blood samples were taken before treatment from 244 incident cases cancer, including 141 premenopausal 103 postmenopausal cases, controls admitted health examination at Tri-Service General...

The aim of the study reported here was to clarify effects academic pressure on fatigue, sleep problems, daytime sleepiness, and depression among senior high school adolescents in Taiwan.This cross-sectional enrolled 757 who were classified into four groups: Grade 1 (n=261), 2 (n=228), 3T (n=199; 3 students had another college entrance test take), 3S (n=69; succeeded their application). Fatigue, quality, assessed using Chinese version Multidimensional Fatigue Symptom Inventory - Short Form,...

Mood disorders are a serious issue for patients with rheumatoid arthritis (RA) because poor mental health can exacerbate the disease course. This study aimed to identify effect of proinflammatory cytokines on mood RA.This was conducted at rheumatology clinic in Northern Taiwan. In total, 113 RA and 42 healthy controls were assessed anxiety depression symptoms using Hospital Anxiety Depression Scale (HADS). Disease Activity Score 28 joints (DAS28). Serum cytokine levels, including interleukin...

ABSTRACT Disseminated castration‐resistant prostate cancer (CRPC) is a common disease in men that characterized by limited survival and resistance to androgen‐deprivation therapy. The increase human epidermal growth factor receptor 2 (HER2) signaling contributes androgen activity subset of patients with CRPC; however, enigmatically, HER2‐targeted therapies have demonstrated lack efficacy CRPC. Aberrant glycosylation hallmark involves key processes support progression. Using transcriptomic...

This study aimed to investigate the association between adults with ADHD and risk of developing dementia.Utilizing National Health Insurance Research Database Taiwan, patients were identified compared age- gender-matched controls (1:3).Of participants, 37 (5.48%) developed dementia 81 (4.0%) in control group. Cox proportional hazards regression analysis revealed that participants more likely develop dementia. The crude hazard ratio (HR) is 3.418 (95% confidence interval [CI] = [2.289,...

Background and Objectives: Amebiasis remains an important public health problem worldwide, immigration increased international travel have affected incident disease cases. This study assesses the prevalence of Entamoeba histolytica in Taiwan between 2011 2020 by analyzing data from surveillance programs conducted Centers for Disease Control (TCDC) on laboratory-confirmed Materials Methods: The E. infection-related reported to National Infectious Diseases Statistics System at TCDC 1 January...

Estrogen has the potential to influence brain physiology implicated in dementia pathogenesis. Hormone replacement therapy (HRT) might be expected risk of dementia. Observational data indicated that HRT was associated with reductions risk, but experimental evidence demonstrates increases incidence To determine effect on dementia, a retrospective cohort study performed using nationwide claims dataset Taiwan.A population-based longitudinal from Longitudinal Health Insurance Database Taiwan. A...

Methylenetetrahydrofolate reductase ( MTHFR ) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both are implicated carcinogenesis. Two common variants gene (C677T A1298C) have been associated with reduced enzyme activity, thereby making polymorphisms a potential candidate cancer-predisposing factor. To evaluate C677T A1298C functional their associations breast cancer risk, as well modifying effect by plasma status on -associated hospital-based...