A5021393041- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Chronic Disease Management Strategies
- Circular RNAs in diseases
- Cervical Cancer and HPV Research
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Sleep and related disorders
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Kruppel-like factors research
- Genomic variations and chromosomal abnormalities
- Health disparities and outcomes
- Healthcare Policy and Management
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Adenosine and Purinergic Signaling
University of Bern
2025
Zhejiang University of Technology
2025
University Hospital of Bern
2025
National Defense Medical Center
2013-2024
Fujian Medical University
2021-2023
Lishui Central Hospital
2022
Wenzhou Medical University
2022
Fujian Provincial Cancer Hospital
2021
China Medical University
2019
Fooyin University
2018
Drug resistance is an obstacle to the treatment of ovarian cancer. Using a unique cell model, we have proven previously that subpopulation cancer cells more resistant cisplatin than are original cells. MicroRNAs (miRNAs), small noncoding RNAs, involved in many biological events In our study, explored whether miRNAs Cisplatin-resistant expressed lower level miR-29a/b/c. Manipulation microRNA-29 (miR-29) expression modulated sensitivity CP70, HeyC2, SKOV3 and A2780 Knockdown miR-29a/b/c...
Significance The existence of intracellular Cl − sensors has long been postulated and sought after. Recent structural in vitro results support that with-no-lysine (WNK) kinases, particularly WNK4, may function as sensors. Here, we demonstrate knockin mice carrying -insensitive WNK4 mutant phenocopy Mendelian disease a previous mouse model caused by gain-of-function mutations WNK4. Furthermore, lose the expected WNK4-mediated stimulation sodium-chloride cotransporter hypokalemia-induced...
Abstract Lactate dehydrogenase B (LDHB) fuels oxidative cancer cell metabolism by converting lactate to pyruvate. This study uncovers LDHB’s role in countering mitochondria-associated ferroptosis independently of lactate’s function as a carbon source. LDHB silencing alters mitochondrial morphology, causes lipid peroxidation, and reduces viability, which is potentiated the inducer RSL3. Unlike LDHA, acts parallel with glutathione peroxidase 4 (GPX4) dihydroorotate (DHODH) suppress decreasing...
Oncogenic activation of the Wnt/β-catenin signaling pathway is common in hepatocellular carcinoma (HCC). Our recent studies have demonstrated that SRY (sex determining region Y)-box 1 (SOX1) and secreted frizzled-related proteins are concomitantly promoter-hypermethylated, this might lead to abnormal Wnt HCC. SOX1 encodes a transcription factor involved regulation embryonic development cell fate determination. However, expression functional role HCC remains unclear. In study, we confirmed...
DNA methylation may be used a potential biomarker for detecting cervical cancer. The authors of this report quantitative analysis 4 genes in full spectrum lesions to test its clinical application.This hospital-based, retrospective, case-control study was conducted 185 patients and included who had normal uterine cervix (n = 53), intraepithelial neoplasm type 1 (CIN1) 37), CIN2 22), CIN3 24), carcinoma situ (CIS) squamous cell (SCC, n 20), adenocarcinoma (AC) 7). Methylation levels the...
The secreted frizzled-related protein 1 gene (SFRP1) encodes a Wnt/beta-catenin signaling antagonist and frequently is inactivated by promoter methylation in many tumors. However, the role of SFRP1 hepatocellular carcinoma (HCC) not clear. Therefore, authors investigated whether common HCC it may influence expression.Four cell lines, 54 HCCs, 42 cirrhotic livers, 21 livers with chronic hepatitis, 15 normal control tissues were analyzed for 1) using methylation-specific polymerase chain...
Apoptosis is a morphologically distinct form of cell death involved in many physiological and pathological processes. The regulation Fas/Apo-1 membrane-mediated apoptosis has also been known to play crucial roles systems. More more naturally occurring antisense RNAs are now regulate, at least part, growing number eukaryotic genes. In this report, we describe the findings novel RNA transcribed from opposite strand intron 1 human Fas gene. Using orientation-specific RT–PCR northern blot...
Abstract Oncogenic activation of the Wnt/β‐catenin signaling pathway is common in hepatocellular carcinoma (HCC). The secreted frizzled‐related proteins (SFRPs) function as negative regulators Wnt and have important implications for carcinogenesis. Promoter hypermethylation SFRP genes human cancers. However, role SFRPs HCC not clear. Recently, we shown that SFRP1 frequently downregulated through promoter hypermethylation. To confirm extend these findings, methylation status other members,...
Although certain inhibitors of histone deacetylases have been shown to induce cytotoxicity alone or in combination with chemotherapeutic agents cancer cells, the molecular mechanism is not clear. The goal present study was determine whether antiseizure drug valproic acid (2‐propylpentanoic acid; VPA), which also able inhibit deacetylase, exhibits synergistic cisplatin, and possible pathways for this. Our results clearly show that VPA only cisplatin all ovarian carcinoma cells tested, but can...
Using DNA methylation biomarkers in cancer detection is a potential direction clinical testing. Some methylated genes have been proposed for cervical detection; however, more reliable markers are needed. To identify new hypermethylated the discovery phase, we compared methylome between pool of from normal epithelium (n = 19) and tissues 38) using bead array. We integrated differentially with public gene expression databases, which resulted 91 candidate genes. Based on after demethylation...
Abstract The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of Wnt pathway common in many cancers. curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved epigenetic regulation inhibit tumor suppressor re-expression. In a compounds screening, we found curcumin can signaling. Therefore, aim this study was investigate effects on SFRP5 DNA...
We found in the present study that stimulation of A(2A) adenosine receptors (A(2A)-R) prevents apoptosis PC12 cells. This A(2A)-protective effect was blocked by protein kinase A (PKA) inhibitors and not observed a PKA-deficient variant. Stimulation PKA also prevented apoptosis, suggesting is required for protective A(2A)-R. general PKC inhibitor, but down-regulation conventional novel PKCs, readily A(2A)-R activation, atypical PKCs (aPKCs) serve critical role downstream PKA. Consistent with...
To characterize phenotypic and genotypic changes in gastric cancer (GC), DNA copy number aberrations (CNAs) were assessed 53 tumors using comparative genomic hybridization (CGH) correlated with clinicopathologic characteristics status of TP53 replication error (RER). The CNAs per tumor was 6.8 (gain 5.3, loss 1.5), the significantly higher advanced stage, mutation, without RER than those early stage (7.7 vs. 3.0), no mutations (12.4 4.8) or phenotype (8.2 2.6). Frequent abnormalities...
Blockage of the p53 tumor suppressor has been found to impair nerve growth factor (NGF)-induced neurite outgrowth in PC-12 cells. We report herein that such impairment could be rescued by stimulation A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>-R), a G protein-coupled implicated neuronal plasticity. The A<sub>2A</sub>-R-mediated rescue occurred presence protein kinase C (PKC) inhibitors or A (PKA) and PKA-deficient variant. Thus, neither PKA nor PKC was involved. In contrast, expression...
Background: Aberrant DNA methylation is associated with the development of hepatocellular carcinoma (HCC), suggesting that gene could be a potential biomarker for detection HCC. The aim this study to identify biomarkers in