A5100696676- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Thyroid Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- RNA Research and Splicing
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- NF-κB Signaling Pathways
- Colorectal and Anal Carcinomas
- ECG Monitoring and Analysis
- Glutathione Transferases and Polymorphisms
The University of Texas MD Anderson Cancer Center
2016-2025
Second Affiliated Hospital of Dalian Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
The University of Texas Health Science Center at Houston
2006-2024
The First People's Hospital of Changde
2022-2024
Ningbo No. 2 Hospital
2012-2024
Hainan Medical University
2020-2024
First Affiliated Hospital Zhejiang University
2019-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
National Clinical Research Center for Digestive Diseases
2024
The characteristics, significance and potential cause of positive SARS-CoV-2 diagnoses in recovered coronavirus disease 2019 (COVID-19) patients post discharge (re-detectable positive, RP) remained elusive.
Abstract BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may alter the processing, transcription, and expression of miRNAs and, thus, contribute to cancer development. The authors hypothesized that common pre‐miRNAs are associated individually (more likely) collectively with risk squamous cell carcinoma head neck (SCCHN). METHODS: genotyped 4 pre‐miRNAs: Homo sapiens miRNA 146a ( hsa‐mir‐146a ) (reference SNP 2910164 [rs2910164]; guanine cytosine [G→C]), hsa‐mir‐149...
Abstract BACKGROUND: In this retrospective review, the authors examined demographic/clinical characteristics and overall survival in patients with squamous cell carcinoma of oropharynx at a tertiary cancer center, they report that influenced any observed trends over time. METHODS: The study included 3891 newly diagnosed, previously untreated who presented authors' institution between 1955 2004. RESULTS: Over time, younger ages were more likely to have base tongue or tonsil tumors be...
Emerging evidence shows that Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a pivotal role in cell proliferation, migration, and invasion tumors. However, the biological underlying mechanism of MALAT1 liver fibrosis remains undefined. In this study, up-regulation was observed fibrotic tissues activated hepatic stellate cells (HSCs). addition, depletion inhibited activation HSCs vitro attenuated collagen deposits vivo. Our results demonstrated expression is negatively...
To determine the long-term efficacy of adjuvant immunotherapy with autologous cytokine-induced killer (CIK) cells for locally advanced gastric cancer patients.One hundred and fifty-one patients stage III/IV who had undergone gastrectomy were enrolled, assigned to two groups (immunotherapy group versus no group/or control group), followed.The 5-year overall survival (OS) disease-free (DFS) rates 32.4 23.4 % (P = 0.071) 28.3 10.4 0.044), respectively. For intestinal-type tumors, OS DFS...
BACKGROUND Circulating Epstein‐Barr virus DNA is a predictor of disease recurrence in patients with nasopharyngeal carcinoma. human papillomavirus (HPV) has been detected the sera some HPV‐positive squamous cell carcinoma oropharynx (OPC). The goal current study was to determine whether pretreatment serum HPV useful biomarker for OPC. METHODS included newly diagnosed, previously untreated Tumor status determined by polymerase chain reaction; using real‐time reaction. Differences clinical...
Previous studies on smokeless tobacco use and head neck cancer (HNC) have found inconsistent often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control (1981–2006) of oral, pharyngeal, laryngeal cancers (6,772 cases 8,375 controls) in the International Head Neck Cancer Epidemiology (INHANCE) Consortium, we applied hierarchical logistic regression to estimate odds ratios 95% confidence intervals ever use, frequency duration snuff chewing...
Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity duration, as joint continuous exposures, on HNC risk. Data from 26 case-control studies in INHANCE Consortium were used, including never current drinkers who drunk ≤10 drinks/day ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal 3340 laryngeal cancers). The dose-response relationship between exposure drinking duration was...
MicroRNAs are a class of small RNAs that important in post-transcriptional gene regulation animals and plants. These single-stranded molecules widely distributed organisms influence fundamental biological processes. Interestingly, recent studies have reported diet-derived plant miRNAs could regulate mammalian expression, these broadened our view cross-kingdom communication. In the present study, we evaluated miRNA levels cooked maize-containing chow diets, found were resistant to harsh...
Abstract Background. An emerging epidemic of human papillomavirus (HPV)‐associated oropharyngeal cancer has been proposed. The purpose this study was for us to compare the sexual behaviors patients with squamous cell carcinoma oropharynx (SCCOP) and non‐oropharyngeal (SCCNOP) head neck sites expand our understanding behavior as a risk factor HPV‐associated cancer. Methods. history 165 SCCOP 87 SCCNOP determined in hospital‐based case‐to‐case comparison study. Results. Patients were...
Lymphatic vessels in primary tumor tissue play an important role lymphatic metastasis. metastasis of malignant neoplasms is significantly related to prognosis, influencing both recurrence and survival. The aim this study was investigate the correlation intra-tumoral vessel density (iLVD) peri-tumoral (pLVD) with biological behavior prognostic parameters pancreatic carcinoma (PC) other tumors. Lymphangiogenesis examined using D2-40 monoclonal antibody 33 cases PC, 7 neuroendocrine tumors...
BACKGROUND A recent review of the Surveillance, Epidemiology, and End Results registry suggested that patients with index squamous cell carcinoma (SCC) oropharynx (SCCOP) are less likely to develop second primary malignancies (SPM) than SCC nonoropharyngeal sites (oral cavity, larynx, hypopharynx). The objectives this study were determine impact tumor site on SPM risk explore factors potentially affect within a large, prospectively accrued cohort head neck (SCCHN). METHODS 2230 incident...
Nucleos(t)ide analogues rarely result in a durable off-treatment response chronic hepatitis B infection, whereas pegylated interferon (Peg-IFN) induces long-lasting only subset of patients. We assessed the effect sequential combination therapy with Peg-IFN-α2a and entecavir e antigen (HBeAg)-positive patients prior long-term investigated predictors to treatment. HBeAg-positive individuals who did not achieve HBeAg seroconversion during previous therapy, receiving added ongoing (sequential...
<h3>Importance</h3> Patients with immunosuppression have a higher incidence of cutaneous squamous cell carcinoma (cSCC) and often present more aggressive, multifocal disease. <h3>Objectives</h3> To determine the risks for mortality in patients cSCC compared nonimmunosuppression to compare difference risk based on cause immunocompromise. <h3>Design, Setting, Participants</h3> This retrospective cohort study head neck recruited participants from tertiary cancer care center. who underwent no...
Smoking, alcohol consumption, and human papillomavirus (HPV) infection are known risk factors for oral squamous cell carcinoma (OSCC) including SCC of oropharynx (SCCOP) cavity (SCCOC). Researchers have examined each these independently, but few observed the potential their interaction. This study investigated interactions among OSCC.Totally 377 patients with newly diagnosed SCCOP SCCOC 433 frequency-matched cancer-free controls by age sex were included. Multivariable logistic regression was...
Nasopharyngeal carcinoma (NPC) is a rare cancer in the U.S. that has well-established association with Epstein-Barr virus(EBV) for WHO types II/III but less so type I. Given rise oropharyngeal tumors positive high risk human papillomavirus (HPV) and unique biology of INPC, we chose to examine relationship between HPV I NPC.Retrospective case comparison study.A search large multidisciplinary center tumor registry identified 183 patients seen from January 1999 December 2008 incident NPC no...
Abstract Purpose: Oropharyngeal carcinoma positive for human papillomavirus type 16 (HPV16) has a significantly better prognosis than oropharyngeal unrelated to HPV. Within HPV16-positive carcinoma, biomarkers of are urgently needed individualize care. We hypothesized that serum antibodies specific HPV16, the major HPV causing have biologic relevance and potential improved among patients with carcinoma. Experimental Design: IgG HPV16 antigens E1, E4-E7, L1, L2, N-terminal C-terminal...
Several long noncoding RNAs (lncRNAs) are involved in oncogenesis. Our microarray analysis showed that numerous lncRNAs dysregulated hypopharyngeal squamous cell carcinoma (HSCC) tumor tissues as compared with normal tissues. Among those lncRNAs, urothelial carcinoma-associated 1 (UCA1) has been found to have an oncogenic role HSCC. We confirmed the upregulation of UCA1 HSCC by assessing its expression levels a cohort 53 patient tumors and paired non-tumor samples. In addition, we high was...
Deregulated microRNAs and their roles in tumorigenesis have attracted much attention recent years. Although miR-503 was shown to be important tumorigenesis, its role osteosarcoma remains unknown. In this study, we focused on the expression mechanisms of development. We found that down-regulated cell lines primary tumor samples, restoration reduced proliferation, migration invasion. Low level patients with associated considerably shortened disease-free survival. Furthermore, bioinformatic...