A5080629319- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Monoclonal and Polyclonal Antibodies Research
- Atmospheric and Environmental Gas Dynamics
- Immune Cell Function and Interaction
- COVID-19 impact on air quality
- Atmospheric Ozone and Climate
- Hydrocarbon exploration and reservoir analysis
- CAR-T cell therapy research
- Vehicle emissions and performance
- Immunotherapy and Immune Responses
- Methane Hydrates and Related Phenomena
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- Atmospheric aerosols and clouds
- Climate variability and models
- Cytomegalovirus and herpesvirus research
- Radiation Detection and Scintillator Technologies
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Meteorological Phenomena and Simulations
- HER2/EGFR in Cancer Research
Qinghai Provincial Peoples Hospital
2025
Nanjing University of Chinese Medicine
2022-2025
Shanghai University
2018-2024
Union Hospital
2024
Jilin University
2024
AstraZeneca (United Kingdom)
2019-2023
Yue Bei People's Hospital
2023
Shantou University
2023
Shanghai Jiao Tong University
2023
Tianjin Medical University
2023
The goal of this research was to harness a monoclonal antibody (mAb) discovery platform identify cell-surface antigens highly expressed on cancer and develop, through Fc optimization, potent mAb therapies toward these tumor-specific antigens.Fifty independent mAbs targeting the immunoregulatory B7-H3 protein were obtained intact cell-based immunizations using human tissue progenitor cells, cell lines, or lines displaying stem properties. Binding studies revealed natively reactive panel bind...
Response to trastuzumab in metastatic breast cancer correlates with expression of the high binding variant (158V) activating Fcγ receptor IIIA (CD16A). We engineered MGAH22, a chimeric anti-HER2 monoclonal antibody specificity and affinity similar trastuzumab, an Fc domain for increased both alleles human CD16A. MGAH22 was compared identical mAb except wild type domain. Antibody-dependent cell cytotoxicity (ADCC) assays were performed HER2-expressing cells as targets PBMC or purified NK...
Abstract Monoclonal antibodies (mAb) are widely used in the treatment of non-Hodgkin's lymphoma and autoimmune diseases. Although mechanism action vivo is not always known, therapeutic activity several approved mAbs depends on binding Fcγ regions to low-affinity receptors (FcγR) expressed effector cells. We did functional genetic screens identify IgG1 Fc domains with improved activating receptor CD16A (FcγRIIIA) reduced inhibitory receptor, CD32B (FcγRIIB). Identification new amino acid...
MGD006, a CD3xCD123 bispecific DART molecule intended for AML treatment, shows anticancer activity in mouse model and favorable pharmacodynamic safety profile nonhuman primates.
B7-H3, also referred to as CD276, is a member of the B7 family immune regulatory proteins. B7-H3 overexpressed on many solid cancers, including prostate cancer, renal cell carcinoma, melanoma, squamous carcinoma head and neck, non-small lung breast cancer. Overexpression associated with disease severity, risk recurrence reduced survival. In this article, we report preclinical development MGC018, an antibody-drug conjugate targeted against B7-H3. MGC018 comprised cleavable linker-duocarmycin...
Abstract. Numerical air quality models (AQMs) have been applied more frequently over the past decade to address diverse scientific and regulatory issues associated with deteriorated in China. Thorough evaluation of a model's ability replicate monitored conditions (i.e., model performance or MPE) helps illuminate robustness reliability baseline modeling results subsequent analyses. However, numerous input data requirements, configurations, evolution themselves, no two AQM applications are...
Abstract Background Thousands of Coronavirus Disease 2019 (COVID-19) patients have been discharged from hospitals Persistent follow-up studies are required to evaluate the prevalence post-COVID-19 fibrosis. Methods This study involves 462 laboratory-confirmed with COVID-19 who were admitted Shenzhen Third People’s Hospital January 11, 2020 April 26, 2020. A total 457 underwent thin-section chest CT scans during hospitalization or after discharge identify pulmonary lesion. 287 followed up 90...
Abstract. The outbreak of COVID-19 promoted strict restrictions to human activities in China, which led a dramatic decrease most air pollutant concentrations (e.g., PM2.5, PM10, NOx, SO2 and CO). However, an obvious increase ozone (O3) was found during the lockdown period urban areas China. In this study, we conducted field measurements targeting its key precursors by utilizing novel proton transfer reaction time-of-flight mass spectrometer (PTR-TOF-MS) Changzhou, is representative Yangtze...
Anti–chikungunya virus antibodies require FcγR engagement but not complement activation for protection and viral clearance.
Abstract. Rapid sulfate formation is recognized as a key characteristic of severe winter haze in China. However, air quality models tend to underestimate during heavy periods, and heterogeneous pathways have been proposed promising mechanisms reduce gaps between observation model simulation. In this study, we implemented reactive SO2 uptake mechanism through the SO2+NO2 reactions Comprehensive Air Quality Model with Extensions (CAMx) improve simulation Yangtze River Delta (YRD) region....
Nonalcoholic fatty liver disease (NAFLD), ranging from nonalcoholic to steatohepatitis (NASH), is the leading cause of chronic diseases. Until now, no medications for NAFLD have been approved by relevant governmental agencies. Dual-specificity phosphatase 9 (Dusp9) a member DUSP protein family. Dusp9 expressed in insulin-sensitive tissues, and its expression may be modified with development insulin resistance (IR). However, molecular targets mechanisms action on NASH remain poorly...
Abstract. Identification of various emission sources and quantification their contributions comprise an essential step in formulating scientifically sound pollution control strategies. Most previous studies have been based on traditional offline filter analysis aerosol major components (usually inorganic ions, elemental carbon – EC, organic OC, elements). In this study, source apportionment PM2.5 using a positive matrix factorization (PMF) model was conducted for urban Shanghai the Yangtze...