A5114044810- COVID-19 diagnosis using AI
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Nicotinic Acetylcholine Receptors Study
- COVID-19 Clinical Research Studies
- Functional Brain Connectivity Studies
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
- Neural dynamics and brain function
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Inflammatory Biomarkers in Disease Prognosis
- Alzheimer's disease research and treatments
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Histone Deacetylase Inhibitors Research
- Mental Health Research Topics
- RNA modifications and cancer
The University of Texas MD Anderson Cancer Center
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Guangxi Medical University
2023-2024
Yan'an University
2024
The University of Texas Health Science Center at Houston
2024
Tianjin Third Central Hospital
2024
Tianjin Medical University
2024
Tianjin Fire Research Institute
2024
Sichuan University
2023-2024
Affiliated Zhongshan Hospital of Dalian University
2018-2023
Abstract Background Thousands of Coronavirus Disease 2019 (COVID-19) patients have been discharged from hospitals Persistent follow-up studies are required to evaluate the prevalence post-COVID-19 fibrosis. Methods This study involves 462 laboratory-confirmed with COVID-19 who were admitted Shenzhen Third People’s Hospital January 11, 2020 April 26, 2020. A total 457 underwent thin-section chest CT scans during hospitalization or after discharge identify pulmonary lesion. 287 followed up 90...
Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment.Irisin, newly discovered myokine adipokine, has been found to have beneficial effects on various cardiovascular diseases.However, the pharmacological effect of irisin antagonizing hypertension-induced vascular not well understood.In present study, we investigated protection mechanisms against induced by angiotensin II (Ang II).Adult male mice wild-type, FNDC5...
Systemic exposure to nicotine induces glutamatergic synaptic plasticity on dopamine (DA) neurons in the ventral tegmental area (VTA), but mechanisms are largely unknown. Here, we report that single, systemic rats (0.17 mg/kg free base) increases ratio of DA neuronal currents mediated by AMPA relative NMDA receptors (AMPA/NMDA ratio) assessed 24 h later, based slice-patch recording. The AMPA/NMDA increase is evident within 1 and lasts for at least 72 after (and up 8 d repeated...
Coactivator-associated arginine methyltransferase 1 (CARM1) promotes the development and metastasis of estrogen receptor alpha (ERα)-positive breast cancer. The function CARM1 in triple-negative cancer (TNBC) is still unclear requires further exploration. Here, we report that proliferation, epithelial-mesenchymal transition, stemness TNBC. upregulated multiple cancers its expression correlates with progression. Genome-wide analysis showed recruited by hypoxia-inducible factor-1 subunit...
Endoplasmic reticulum (ER) stress plays an important role in metabolic diseases like obesity and type 2 diabetes mellitus (T2DM), although the underlying mechanisms regulatory pathways remain to be elucidated. Here, we induced chronic low-grade ER lean mice levels similar those high-fat diet (HFD)–fed obese found that it promoted hyperglycemia due enhanced hepatic gluconeogenesis. Mechanistically, sustained up-regulated deubiquitinating enzyme ubiquitin-specific peptidase 14 (USP14), which...
Abstract Background Metastatic cervical squamous cell carcinoma (CSCC) has poor prognosis and is recalcitrant to the current treatment strategies, which warrants necessity identify novel prognostic markers therapeutic targets. Given that CSCC a virus-induced malignancy, we hypothesized pattern recognition receptors (PRRs) involved in innate immune response likely play critical role tumor development. Methods A bioinformatics analysis, qPCR, IHC, immunofluorescence, WB were performed...
Circadian rhythms, as physiological systems with self-regulatory functions in living organisms, are controlled by core clock genes and involved tumor development. The protein arginine methyltransferase 6 (PRMT6) serves an oncogene a myriad of solid tumors, including breast cancer. Hence, the primary aim current study is to investigate molecular mechanisms which PRMT6 complex promotes cancer progression. results show that PRMT6, poly(ADP-ribose) polymerase 1 (PARP1), cullin 4 B (CUL4B)-Ring...
Abstract Human endogenous retroviruses (HERVs) are the remnants of ancient retroviral infections integrated into human genome. Although most HERVs silenced or rendered inactive by various regulatory mechanisms, they retain potential to influence nearby genes. We analyzed map 91 HERV-Ks on neighboring genes in breast cancer and investigated impact tumor microenvironment (TME) prognosis cancer. Nine RNA-seq datasets were obtained from GEO NCBI SRA. Differentially expressed using DESeq2....
Low bodyweight and hypoalbuminemia are independently associated with osteoporosis. In this study, the relationship among Geriatric Nutritional Risk Index (GNRI), bone mineral density (BMD) osteoporosis in type 2 diabetes mellitus patients was explored, GNRI predictive value evaluated.
Proteins containing the Jumonji C (JmjC) domain participated in tumorigenesis and cancer progression. However, mechanisms underlying this effect are still poorly understood. Our objective was to investigate role of AT-rich interaction domain-containing 2 (JARID2) - a JmjC family protein breast cancer, as well its latent association with obesity.Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, other databases were used analyze expression JARID2 cells. Growth curve,...
The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated substrates. USP28 controls hypoxia-dependent angiogenesis metastasis by preventing FBXW7-dependent hypoxia-inducible transcription factor-1α (HIF-1α) during hypoxia. However, it remains unclear how activation HIF-1α signaling are coordinated response to vitro deubiquitinating...
Colorectal cancer (CRC) is one of the most common malignant tumors. Approximately 5%-6% CRC cases are associated with hereditary syndromes, including Peutz-Jeghers syndrome (PJS). Liver kinase B1 (LKB1), also known as STK11, major gene responsible for PJS. LKB1 heterozygotic deficiency involved in intestinal polyps mice, while mechanism remains elusive. In this study, we generated knockout (KO) cell lines by using CRISPR-Cas9. KO promoted motility vitro and tumor metastases vivo. attenuated...
Systemic administration of nicotine increases dopaminergic (DA) neuron firing in the ventral tegmental area (VTA), which is thought to underlie reward. Here, we report that medial prefrontal cortex (mPFC) plays a critical role nicotine-induced excitation VTA DA neurons. In chloral hydrate-anesthetized rats, extracellular single-unit recordings showed neurons exhibited two types responses systemic nicotine. After injection, with type-I response biphasic early inhibition and later excitation,...
Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that characterized by accumulation excessive triglyceride (TG) in hepatocytes. However, the factors involved obesity-induced hepatosteatosis are poorly defined. Here, we report SRY-box containing gene 4 (Sox4), a transcription factor regulates cell proliferation and differentiation, plays important role hepatic TG metabolism. Sox4 expression levels markedly upregulated livers obese rodents humans....
This study analyzed and compared CT findings longitudinal variations after discharge between severe non-severe coronavirus disease (COVID-19) patients who had residual pulmonary sequelae at pre-discharge.A total of 310 were included stratified into COVID-19 groups. Cross-sectional features across different time periods (T0: pre-discharge, T1: 1-4 weeks discharge, T2: 5-8 T3: 9-12 T4: > 12 discharge) compared, the in both groups.The cumulative absorption rate fibrosis-like groups T4 was 24.3%...
Recent publications highlight differences within the sub-regions of ventral tegmental area (VTA) including parabrachial pigmented nucleus (PBP), parainterfascicular (PIF) and paranigral (PN) in projections to prefrontal cortex (PFC) glutamatergic pathway.In order characterize effects prenatal nicotine exposure on mesocorticolimbic system rat offspring, local field potentials were recorded from 27 sites across VTA 9 rats aged 40-55 days. The extracellular neural activities analyzed using...
The dopamine (DA) neurons found in the ventral tegmental area (VTA) are widely involved addiction and natural reward circuitry of brain. Their firing patterns were shown to be important modulators release repetitive burst-like activity was highlighted as a major pattern DA VTA. In present study we use state space model characterize patterns, trace transitions neural through bursting non-bursting states. hidden semi-Markov (HSMM) framework, which use, offers statistically principled inference...