A5101429362- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Advanced MIMO Systems Optimization
- Phytochemistry and Biological Activities
- Millimeter-Wave Propagation and Modeling
- Plant and animal studies
- Natural product bioactivities and synthesis
- Fern and Epiphyte Biology
- Antenna Design and Analysis
- Cancer-related gene regulation
- Mineral Processing and Grinding
- Ferroptosis and cancer prognosis
- Transportation and Mobility Innovations
- Granular flow and fluidized beds
- Cancer-related molecular mechanisms research
- Gold and Silver Nanoparticles Synthesis and Applications
- Bioactive natural compounds
- Mass Spectrometry Techniques and Applications
- Cyclone Separators and Fluid Dynamics
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Smart Parking Systems Research
- Wireless Sensor Networks and IoT
- Wireless Power Transfer Systems
Kunming Institute of Botany
2023-2025
Chinese Academy of Sciences
2023-2025
University of Chinese Academy of Sciences
2023-2025
First Affiliated Hospital Zhejiang University
2025
Southeast University
2024
Tianjin Medical University
2019-2024
Hangzhou Dianzi University
2022-2024
China University of Mining and Technology
2023-2024
Chang'an University
2023-2024
Beijing University of Posts and Telecommunications
2023-2024
The sixth generation (6G) mobile communications have attracted substantial attention in the global research community of information and communication technologies (ICT). 6G systems are expected to support not only extended 5G usage scenarios, but also new such as integrated sensing (ISAC), artificial intelligence (AI) communication, ubiquitous connectivity. To realize this goal, channel characteristics must be comprehensively studied properly exploited, so promote design, standardization,...
The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations EZH2 and their role cancer pathogenesis. Here, we show that SET MYND domain containing (SMYD2) directly methylates at 307 (K307) enhances its stability, which can be relieved by H3K4 demethylase lysine-specific 1 (LSD1). SMYD2 critical for function repressing cohort genes governing...
Coactivator-associated arginine methyltransferase 1 (CARM1) promotes the development and metastasis of estrogen receptor alpha (ERα)-positive breast cancer. The function CARM1 in triple-negative cancer (TNBC) is still unclear requires further exploration. Here, we report that proliferation, epithelial-mesenchymal transition, stemness TNBC. upregulated multiple cancers its expression correlates with progression. Genome-wide analysis showed recruited by hypoxia-inducible factor-1 subunit...
Surface-enhanced Raman spectroscopy (SERS) has exhibited great potential in label-free DNA detection. Owing to the limitation chain length, it is however still challenging for SERS as a routine method explore intrinsic structural information on unmodified DNA. Here, we develop universal SERS-based approach toward quantification of A/G single-stranded DNAs (12 up 28 bases) by introducing novel interfacial agent, dichloromethane. hybridization successfully probed evidenced typical bands...
Circadian rhythms, as physiological systems with self-regulatory functions in living organisms, are controlled by core clock genes and involved tumor development. The protein arginine methyltransferase 6 (PRMT6) serves an oncogene a myriad of solid tumors, including breast cancer. Hence, the primary aim current study is to investigate molecular mechanisms which PRMT6 complex promotes cancer progression. results show that PRMT6, poly(ADP-ribose) polymerase 1 (PARP1), cullin 4 B (CUL4B)-Ring...
Deregulation of E3 ubiquitin ligases drives the proliferation and metastasis various cancers; however, underlying mechanisms remain unknown. This study aimed to investigate role tripartite motif-containing 22 (TRIM22), a poorly investigated ligase in TRIM family, as tumor suppressor breast cancer. High expression TRIM22 cancer correlated with better prognosis. Functional experiments demonstrated that significantly inhibited invasion cells. Label-free proteomics biochemical analyses revealed...
Proteins containing the Jumonji C (JmjC) domain participated in tumorigenesis and cancer progression. However, mechanisms underlying this effect are still poorly understood. Our objective was to investigate role of AT-rich interaction domain-containing 2 (JARID2) - a JmjC family protein breast cancer, as well its latent association with obesity.Immunohistochemistry, The Cancer Genome Atlas, Gene Expression Omnibus, other databases were used analyze expression JARID2 cells. Growth curve,...
Summary Flower scent is a crucial determiner in pollinator attraction and significant horticultural trait ornamental plants. Orchids, which have long been of interest evolutionary biology horticulture, exhibit remarkable diversity floral type intensity. However, the mechanisms underlying biosynthesis regulation orchids remain largely unexplored. In this study, we focus on Cymbidium tracyanum , wild species known for its strong fragrance as primary breeding parent commercial hybrids. We...
<title>Abstract</title> Neoadjuvant Immunochemotherapy (NAIC) shows promising application prospects in the treatment of (Gastric Cancer, GC) patients. However, differences between individual patients and issue resistance significantly affect whether could truly benefit from this treatment. This study conducted metabolomic analysis 369 plasma samples 108 gastric cancer following NAIC to characterize their metabolic profiles for more accurate therapeutic efficacy prediction. Machine learning...
Abstract The contrasting water availabilities of epiphytic and terrestrial habitats likely drive divergent adaptive strategies for use in plants. While leaf adaptations are well studied, the role root traits adaptation remains poorly understood. Here, we compared anatomical 9 15 species within Cymbidium (Orchidaceae) using a common garden experiment. Our results demonstrated that exhibited leaves with larger stomata roots enhanced cortical development, whereas epiphytes possessed thicker...
Direct, label-free sequence analysis of DNA hybridization has been achieved by surface-enhanced Raman spectroscopy. In this work, aluminum-ion-aggregated and iodide-modified silver nanoparticles were used as substrates to obtain spectra the strands with same base composition but different sequences, which form random coils or various hairpin conformations. Upon hybridization, reproducibly enhanced bands easily observed, corresponding well formation Watson–Crick hydrogen bonds, ring breathing...
Purpose The electromechanical brake system is leading the latest development trend in railway braking technology. tolerance stack-up generated during assembly and production process catalyzes slight geometric dimensioning tolerancing between motor stator rotor inside cylinder. leads to imprecise control, so it necessary diagnose fault of fully assembled system. This paper aims present improved variational mode decomposition (VMD) algorithm, which endeavors elucidate push boundaries...
Background Colorectal cancer (CRC) is an aggressive primary intestinal malignancy with the third-highest incidence and second-highest mortality among all types worldwide. Transcription factors (TFs) regulate cell development differentiation owing to their ability recognize specific DNA sequences upstream of genes. Numerous studies have demonstrated a strong correlation between TFs, etiology tumors, therapeutic approaches. Here, we aimed explore prognosis-related TFs comprehend carcinogenic...
In the present work, we developed an UV-absorptive and highly reactive tag aromatic molecule, quinoline-5,8-dione (QLD), for robust quantitative analysis of GSH by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The QLD could react with high efficiency at room temperature, resultant QLD-GSH conjugate be readily detected MALDI MS without interferences. By using tag, detection limit was lowered to 10 fmol μL-1, which four orders magnitude higher than that tag....
Recent studies have demonstrated that nicotine exhibited anti-inflammatory and neuroprotective properties by interacting with the alpha 7 nicotinic acetylcholine receptor (α7nAChR). However, role of in regeneration during peripheral nerve injury has not been elucidated. The aim this study was to investigate whether down-regulated production proinflammatory cytokines promoted rats. Rats challenged sciatic crush were treated (1.5 mg/kg), three times per day. expression tumor necrosis factor...