A5003791054- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Antimicrobial Resistance in Staphylococcus
- Enterobacteriaceae and Cronobacter Research
- Bacterial Genetics and Biotechnology
- Infections and bacterial resistance
- Microbial Metabolism and Applications
- Vibrio bacteria research studies
- Hair Growth and Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Skin and Cellular Biology Research
- Endometrial and Cervical Cancer Treatments
- RNA and protein synthesis mechanisms
- Microbial infections and disease research
- Machine Learning in Bioinformatics
- Wnt/β-catenin signaling in development and cancer
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture disease management and microbiota
- Plant Pathogenic Bacteria Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
Baotou Central Hospital
2018-2024
Capital Medical University
2021-2024
Wenzhou Medical University
2012-2021
Capital University
2021
Tongji University
2019-2021
Baotou Medical College
2013-2021
Fudan University
2019-2020
Shanghai East Hospital
2019-2020
Inner Mongolia University
2012-2020
Life Science Institute
2015-2020
The dermal papilla is thought to establish the character and control size of hair follicles. Inner Mongolia Cashmere goats (Capra hircus) have a double coat comprising primary secondary follicles, which dramatically different sizes textures. goat rapidly becoming potent model for follicle morphogenesis research. In this study, we established two cell lines during anagen phase growth cycle from follicles clarified similarities differences in their morphology characteristics. High-throughput...
Bacterial resistance to the antibiotics has become an important concern for public health. This study was aimed investigate characteristics and distribution of florfenicol-related genes in bacteria isolated from 4 farms. A total 106 florfenicol-resistant Gram-negative bacilli were examined positive isolates further characterized. Antimicrobial sensitivity results showed that most them (100, 94.33%) belonged multidrug Enterobacteriaceae. About 91.51% strains carried floR gene, 4.72% cfr gene....
Deregulation of E3 ubiquitin ligases drives the proliferation and metastasis various cancers; however, underlying mechanisms remain unknown. This study aimed to investigate role tripartite motif-containing 22 (TRIM22), a poorly investigated ligase in TRIM family, as tumor suppressor breast cancer. High expression TRIM22 cancer correlated with better prognosis. Functional experiments demonstrated that significantly inhibited invasion cells. Label-free proteomics biochemical analyses revealed...
Florfenicol is a derivative of chloramphenicol that used only for the treatment animal diseases. A key resistance gene florfenicol, floR, can spread among bacteria same and different species or genera through horizontal transfer. To analyze potential transmission genes between human pathogens, we investigated floR in Klebsiella pneumoniae isolates from patient samples. pathogens may originate would reflect risk to health using antimicrobial agents animals.PCR was identify floR-positive...
Many Pseudomonas aeruginosa virulence traits that contribute to human infections are accepted as being associated with its environmental lifestyle. Therefore, identifying the molecular mechanisms govern lifestyle choice is of high significance. We previously reported a mutation in suhB results decrease swimming motility and increased biofilm formation compared wild-type strain. Yet, little known about how this occurs. In study, we demonstrated SuhB inversely regulates through...
Abstract As endometrial cancer (EC) is a major threat to female health worldwide, the ability provide an accurate diagnosis and prognosis of EC promising improve its treatment guidance. Since discovery miRNAs, it has been realized that miRNAs are associated with every cell function, including malignant transformation metastasis. This study aimed explore diagnostic prognostic miRNA markers EC. In this study, differential analysis machine learning were performed, followed by correlation...
The emergence of highly drug-resistant K. pneumoniae, has become a major public health challenge. In this work, we aim to investigate the diversity species and sequence types (STs) clinical Klebsiella isolates characterize prevalence structure class 1 integrons.Based on whole genome sequencing, identification was performed by 16S rRNA gene homology average nucleotide identity (ANI) analysis. STs were determined in accordance with international MLST schemes for pneumoniae variicola. Integron...
Arthrospira platensis is a multi-cellular and filamentous non-N2-fixing cyanobacterium that capable of performing oxygenic photosynthesis. In this study, we determined the nearly complete genome sequence A. YZ. YZ single, circular chromosome 6.62 Mb in size. Phylogenetic comparative genomic analyses revealed was more closely related to NIES-39 than sp. PCC 8005 C1. Broad gene gains were identified between three other speices, some which have been previously demonstrated can be laterally...
Abstract Background With the wide use of florfenicol to prevent and treat bacterial infection domestic animals, emergence resistance bacteria is increasingly serious. It very important elucidate molecular mechanism bacteria’s florfenicol. Methods The minimum inhibitory concentration (MIC) levels were determined by agar dilution method, polymerase chain reaction was conducted analyze distribution genes in 39 CoNS strains isolated from poultry livestock animals seafood. whole genome sequence...
Klebsiella pneumoniae is a clinically significant species of bacterium which causes variety diseases. Clinical treatment this bacterial infection greatly hindered by the emergence multidrug-resistant strains. The resistance largely due to acquisition plasmids carrying drug-resistant as well pathogenic genes, and its conjugal transfer facilitates spread resistant phenotypes.The 70,057 bp plasmid pKF3-70, commonly found in pneumoniae, composed five main functional modules, including regions...
Summary γ‐aminobutyric acid (GABA) has been found accumulating significantly in soybean seeds during germination. However, the mechanism of process is not clear. Therefore, gene expression, enzyme activity and metabolites associated with GABA shunt ZH 13 germination were analysed this paper. content 5‐day germinated was 0.26 ± 0.016 mg g −1 DW , which equivalent to six times concentration original soybean. The GAD a positive effect on accumulation as well ‐T play significant role degradation...
The accurate diagnosis of endometrial cancer (EC) holds great promise for improving its treatment choice and prognosis prediction. This work aimed to identify diagnostic biomarkers differentiating EC tumors from in other tissues, as well prognostic signatures predicting survival patients. We identified 48 tissue-specific markers using a cohort genome-wide methylation data three common gynecological their corresponding normal tissues. A classifier was constructed based on these CpG that could...
To investigate the mechanisms of multiple resistance and horizontal transfer genes in animal pathogens, we characterized molecular structures gene-related sequences a multidrug-resistant Klebsiella pneumoniae strain R46 isolated from rabbit. Molecular cloning was performed to clone genes, minimum inhibitory concentrations (MICs) were measured determine characteristics cloned related strains. A conjugation experiment conducted assess transferability plasmids. Sequencing comparative genomic...
Staphylococcus caprae, capitis and epidermidis belong to the "Epidermidis Cluster Group" (ECG) are generally opportunistic pathogens. In this work, whole genome sequencing, molecular cloning pan-genome analysis were performed investigate genetic characteristics of resistance, virulence structures 69 ECG strains, including a clinical isolate (S. caprae SY333) obtained in work. Two resistance genes (blaZ aadD2) encoded on plasmids pSY333-41 pSY333-45 S. SY333 confirmed be functional. The bla...
The aim of this study was to analyze the molecular epidemiologic characteristics Acinetobacter baumannii. A total 398 isolates were collected in 7 regions South China from January June 2012. Drug sensitivity tested toward 15 commonly used antibiotics; thus, 146 multi-drug-resistant strains (resistant more than drugs) identified, representing 36.7% all isolates. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) for subtyping. According PFGE results (with a cutoff...
Abstract Endometrial carcinoma ( EC ) is the most common malignant tumor of female genital tract in developed countries. The prognosis early stage favorable, but a subset faces high risk cancer progression or recurrence. has poor upon to advanced metastatic stages. Therefore, our goal build robust prognostic model for predicting overall survival OS patients. In this study, 1571 genes were identified as being associated with based on genomewide expression profiles using training dataset....
The diversity of class D β-lactamases mediating resistance to β-lactams has been increasingly reported recently. In this study, a novel oxacillinase named OXA-830 was identified in fully sequenced Aeromonas simiae strain, which isolated from sewage discharged farm southern China. shares the highest amino acid identity 79.3% with an OXA-12-like variant OXA-725. When expressed E. coli DH5α, conferred penicillins and selected β-lactamase inhibitors but not cephalosporins carbapenems. Kinetic...