A5085490668- Cancer-related molecular mechanisms research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Research and Splicing
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Physiological and biochemical adaptations
- Reproductive biology and impacts on aquatic species
- Genomics and Phylogenetic Studies
- Urinary Tract Infections Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Genetic Mapping and Diversity in Plants and Animals
- Marine Bivalve and Aquaculture Studies
- Fish Ecology and Management Studies
- Genetic and Kidney Cyst Diseases
- Antibiotic Use and Resistance
- Fish Biology and Ecology Studies
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Environmental Toxicology and Ecotoxicology
- Chromosomal and Genetic Variations
Central China Normal University
2025
Chinese Academy of Fishery Sciences
2012-2025
Qingdao National Laboratory for Marine Science and Technology
2019-2025
Dalian Polytechnic University
2025
Northwest A&F University
2011-2025
Chengdu Research Base of Giant Panda Breeding
2022-2025
Tianjin Academy of Agricultural Sciences
2024
Westlake University
2024
Ministry of Agriculture and Rural Affairs
2020-2024
Wenzhou Medical University
2014-2024
Abstract Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 putative male determination gene, but direct genetic evidence still lacking. Here we show TALEN of efficiently induced mutations this gene. The ZZ mutant developed ovary-like testis, and spermatogenesis was disrupted. female-related genes foxl2 cyp19a1a were significantly increased in gonad mutant. Conversely, male-related Sox9a Amh decreased. deficient grew much...
Antarctic krill (Euphausia superba) is Earth’s most abundant wild animal, and its enormous biomass vital to the Southern Ocean ecosystem. Here, we report a 48.01-Gb chromosome-level genome, whose large genome size appears have resulted from inter-genic transposable element expansions. Our assembly reveals molecular architecture of circadian clock uncovers expanded gene families associated with molting energy metabolism, providing insights into adaptations cold highly seasonal environment....
Abnormal alternative splicing (AS) caused by alterations to factors contributes tumor progression. Serine/arginine factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure glioma. Here, we demonstrate that SRSF1 is increased glioma tissues cell lines. Moreover, expression was correlated positively with grade Ki-67 index, but inversely patient survival. Using RNA-Seq, comprehensively screened identified multiple SRSF1-affected...
Muscle fibres are multinucleated post-mitotic cells that can change dramatically in size during adulthood. It has been debated whether muscle fibre hypertrophy requires activation and fusion of stem cells, the satellite cells. Myostatin (MSTN) is a negative regulator skeletal growth development adult, MSTN inhibition therefore potential therapy for wasting diseases, some which associated with depletion Conflicting results have obtained previous analyses role on cell quiescence. Here, we...
Abstract Chinese sea bass ( Lateolabrax maculatus ) is a highly sought-after commercial seafood species in Asian regions due to its excellent nutritional value. With the rapid advancement of bioinformatics, higher standards for genome analysis compared previously published reference genomes are now necessary. This study presents gapless assembly genome, which has length 632.75 Mb. The sequences were assembled onto 24 chromosomes with coverage over 99% (626.61 Mb), and telomeres detected on...
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties allow GR tune gene expression match specific physiologic demands are poorly understood. We analyzed the consequences of activation murine lungs deficient for KLF15, a regulator amino acid is induced by glucocorticoids and fasting. Approximately 7% glucocorticoid-regulated genes had altered Klf15-knockdown (Klf15−/−) mice. KLF15 formed coherent...
Abstract Background For metabolic engineering, many rate-limiting steps may exist in the pathways of accumulating target metabolites. Increasing copy number desired genes these is a general method to solve problem, for example, employment multi-copy plasmid-based expression system. However, this bring genetic instability, structural instability and burden host, while integrating gene into chromosome cause inadequate transcription or expression. In study, we developed strategy obtaining...
Vibrio harveyi causes vibriosis in nearly 70% of grouper (Epinephelus sp.), seriously limiting culture. As well as directly inhibiting pathogens, the gut microbiota plays critical roles immune homeostasis and provides essential health benefits to its host. However, there is still little information about variations response V. infection grouper. To understand virulence mechanism pearl gentian grouper, we investigated pathological changes, responses, bacterial communities after exposure...
RH6, RH8, and RH12 are previously unidentified D-body components drive the formation of D-bodies through LLPSs.
Cauliflower (Brassica oleracea L. var. botrytis) is a distinctive vegetable that supplies nutrient-rich edible inflorescence meristem for the human diet. However, genomic bases of its selective breeding have not been studied extensively. Herein, we present high-quality reference genome assembly C-8 (V2) and comprehensive variation map consisting 971 diverse accessions cauliflower relatives. Genomic selection analysis deep-mined divergences were used to explore stepwise domestication process...
Low temperatures may cause severe growth inhibition and mortality in fish. In order to understand the mechanism of cold tolerance, a transgenic zebrafish Tg (smyd1:m3ck) model was established study effect energy homeostasis during stress. The muscle-specific promoter Smyd1 used express carp muscle form III creatine kinase (M3-CK), which maintained enzymatic activity at relatively low temperature, skeletal muscle. situ hybridization showed that M3-CK expressed strongly When exposed 13 °C,...
miR-145 is a candidate tumor suppressor miRNA. However, it unknown whether involved in the invasion of hepatocellular carcinoma (HCC). Therefore, we aimed to explore effect and mechanism control HCC cell invasion.HCC was evaluated by transwell assays after transfection with pre-miR-145 or anti-miR-145. A luciferase reporter assay used determine disintegrin metalloprotease 17 (ADAM17) were target miR-145. The levels ADAM17 mRNA detected real-time polymerase chain reaction assay, level protein...