Haoxiang Chen

ORCID: 0009-0009-6532-4907
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About
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Research Areas
  • Aquaculture disease management and microbiota
  • Vibrio bacteria research studies
  • Adsorption and biosorption for pollutant removal
  • Antibiotic Resistance in Bacteria
  • Analytical chemistry methods development
  • Effects and risks of endocrine disrupting chemicals
  • Microbial Community Ecology and Physiology
  • Pharmaceutical and Antibiotic Environmental Impacts
  • RNA and protein synthesis mechanisms
  • Bacterial Genetics and Biotechnology
  • Yersinia bacterium, plague, ectoparasites research
  • Bacterial biofilms and quorum sensing
  • Microbial Fuel Cells and Bioremediation
  • Reinforcement Learning in Robotics
  • Regional Development and Environment
  • Medical Imaging and Analysis
  • Urban Heat Island Mitigation
  • Environmental DNA in Biodiversity Studies
  • Optimization and Search Problems
  • Advanced Graph Neural Networks
  • Wireless Body Area Networks
  • Nanomaterials for catalytic reactions
  • Wastewater Treatment and Nitrogen Removal
  • Clay minerals and soil interactions
  • Antenna Design and Optimization

Beijing Institute of Technology
2025

Dongguan University of Technology
2024

Beijing Technology and Business University
2024

National Kaohsiung University of Science and Technology
2023

Université Toulouse III - Paul Sabatier
2023

Université de Toulouse
2023

Centre National de la Recherche Scientifique
2023

Ministry of Agriculture and Rural Affairs
2020-2023

Chinese Academy of Fishery Sciences
2020-2023

Shanghai Ocean University
2020-2023

Abstract Here, 70 potential Vibrio pathogens belonging to nine species, dominated by harveyi , were isolated and identified from diseased aquacultured marine fish in South China. Subsequently, the prevalence of 11 virulence genes resistance 15 antibiotics these strains determined. Most possessed atypical addition typical genes. Notably, hflk chiA originating V. flaC associated with anguillarum detected more than 40% host strains. Multidrug was widespread: 64.29% resistant three antibiotics,...

10.1038/s41598-020-71288-0 article EN cc-by Scientific Reports 2020-08-31

Vibrio harveyi causes vibriosis in nearly 70% of grouper (Epinephelus sp.), seriously limiting culture. As well as directly inhibiting pathogens, the gut microbiota plays critical roles immune homeostasis and provides essential health benefits to its host. However, there is still little information about variations response V. infection grouper. To understand virulence mechanism pearl gentian grouper, we investigated pathological changes, responses, bacterial communities after exposure...

10.3389/fimmu.2020.607754 article EN cc-by Frontiers in Immunology 2020-11-26

Lipopolysaccharide (LPS) assembly at the surfaces-exposed leaflet of bacterial outer membrane (OM) is mediated by OM LPS translocon. An essential transmembrane beta-barrel protein, LptD, and a cognate lipoprotein, LptE, translocate selectively into external via poorly understood mechanism. Here, we characterize two additional translocon subunits, lipoproteins LptM LptY (formerly YedD). We use single-particle cryo-EM analysis, functional assays molecular dynamics simulations to visualize...

10.1101/2025.04.10.648201 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2025-04-10

Abstract Insertion of lipopolysaccharide (LPS) into the bacterial outer membrane (OM) is mediated by a druggable OM translocon consisting β-barrel protein, LptD, and lipoprotein, LptE. The assembly machinery (BAM) assembles LptD together with LptE at OM. In enterobacterium Escherichia coli , formation two native disulfide bonds in controls activation. Here we report discovery LptM (formerly YifL), lipoprotein conserved Enterobacteriaceae that BAM complex. stabilizes conformation can...

10.1038/s41467-023-42007-w article EN cc-by Nature Communications 2023-10-11

Recent advancements in autonomous driving, augmented reality, robotics, and embodied intelligence have necessitated 3D perception algorithms. However, current methods, particularly small models, struggle with processing logical reasoning, question-answering, handling open scenario categories. On the other hand, generative multimodal large language models (MLLMs) excel general capacity but underperform tasks, due to weak spatial local object perception, poor text-based geometric numerical...

10.48550/arxiv.2408.07422 preprint EN arXiv (Cornell University) 2024-08-14

Land surface temperatures (LST) are vital parameters in land surface-atmosphere interactions. Constrained by technology and atmospheric interferences, LST retrievals from various satellite sensors usually return missing data, thus negatively impacting analyses. Reconstructing data is important for acquiring gap-free datasets. However, the current reconstruction methods limited maintaining spatial details high accuracies. We developed a new algorithm termed feature-considered random forest...

10.3390/s23020913 article EN cc-by Sensors 2023-01-12

Sea bass (Lateolabrax maculatus) is the third largest maricultured fish in terms of abundance on mainland China. However, sea has been reported to be susceptible infection by a series microbial pathogens, endangering sustainable development its mariculture. Therefore, there need clarify relationship between occurrence disease and surrounding communities, verify particular bacterial assemblages that indicate health status (either healthy or diseased), with important implications for...

10.1016/j.ecolind.2021.107775 article EN cc-by-nc-nd Ecological Indicators 2021-05-05

Antibiotic resistance represents a global health crisis for humans, animals, and the environment. However, few studies address abundance distribution of environmental bacterial antibiotic associated with farmed fish during early breeding stages their relationship aquaculture In this study, culture-dependent methods gene chip technology were respectively used to identify detect cultivable heterotrophic resistant bacteria (ARB) genes (ARGs) water samples from 20 sea bass-rearing ponds in...

10.3389/fmars.2023.1139641 article EN cc-by Frontiers in Marine Science 2023-04-05

Vibrio harveyi is a common aquaculture pathogen causing diseases in variety of aquatic animals. toxR, conserved virulence-associated gene vibrios, identified V. 345, pathogenic strain isolated from diseased fish. In this study, to gain insight into function ToxR harveyi, an in-frame deletion the toxR was constructed reveal role physiology and virulence harveyi. The statistical analysis showed no significant differences growth ability, motility, extracellular protease secretion, antibiotic...

10.1111/lam.13606 article EN Letters in Applied Microbiology 2021-11-25

Vibrio harveyi can cause infections and diseases in a variety of marine vertebrates invertebrates, which are harmful to the aquaculture industry. The LuxS quorum-sensing system regulates expression virulence factors wide pathogenic bacteria. In this study, an in-frame deletion luxS gene was constructed reveal role physiology V. harveyi. Statistical analysis showed no significant differences growth ability, biofilm formation, antibiotic susceptibility, by intraperitoneal injection, ability...

10.1139/cjm-2021-0311 article EN Canadian Journal of Microbiology 2021-12-02

AIGC images are prevalent across various fields, yet they frequently suffer from quality issues like artifacts and unnatural textures. Specialized models aim to predict defect region heatmaps but face two primary challenges: (1) lack of explainability, failing provide reasons analyses for subtle defects, (2) inability leverage common sense logical reasoning, leading poor generalization. Multimodal large language (MLLMs) promise better comprehension reasoning their own difficulty in...

10.48550/arxiv.2411.17261 preprint EN arXiv (Cornell University) 2024-11-26

Based on input-output table and energy consumption balance sheet of Guangdong Province in 2012, this paper formulates non-competitive Province, calculates intensity, carbon intensity sensitivity coefficient emission reduction saving various departments.By applying model to the analysis fulfillment under measures during 12th Five-Year Plan conclusions are drawn that devotion structure optimization, industrial restructuring higher efficiency level respectively mount 13.1%,8.20%and78.7%, while...

10.2991/iccahe-16.2016.24 article EN cc-by-nc 2016-01-01

ABSTRACT Insertion of lipopolysaccharide (LPS) into the outer membrane (OM) Gram-negative bacteria is mediated by a druggable OM translocon consisting β-barrel protein, LptD, and lipoprotein, LptE. The assembly machinery (BAM) assembles LptD together with LptE to form plug-and-barrel structure. In enterobacterium Escherichia coli , formation two native disulfide bonds in controls LPS activation. Here we report discovery LptM (formerly YifL), conserved lipoprotein that at BAM complex. We...

10.1101/2023.01.02.522452 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-01-03
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