A5100431908- interferon and immune responses
- Signaling Pathways in Disease
- Cytokine Signaling Pathways and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Aquaculture disease management and microbiota
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Insect-Plant Interactions and Control
- SARS-CoV-2 and COVID-19 Research
- Bone and Dental Protein Studies
- Plant biochemistry and biosynthesis
- Plant Molecular Biology Research
- Galectins and Cancer Biology
- RNA regulation and disease
- Research in Cotton Cultivation
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
Shanghai University of Traditional Chinese Medicine
2024-2025
Yueyang Hospital
2025
Hunan Normal University
2025
Sun Yat-sen University
2008-2024
Henan Agricultural University
2017-2024
Shuguang Hospital
2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Ministry of Agriculture, Livestock, and Food Supply
2015-2024
Northwest A&F University
2015-2024
City of Hope
2023-2024
Osteosarcoma (OS) is a malignant bone tumor that mainly occurs in adolescents. It accompanied by high rate of lung metastasis, and mortality. Recent studies have suggested the important roles tripartite motif-containing (TRIM) family proteins regulating various substrates signaling pathways different tumors. However, detailed functional role TRIM progression OS still unknown requires further investigations. In this study, we found 22 (TRIM22) was downregulated tissues hence associated with...
RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found cyclophilin A (CypA), peptidyl-prolyl cis/trans isomerase, functioned as critical positive regulator of RIG-I-mediated antiviral immune responses. Deficiency CypA impaired IFN production and promoted viral replication in human cells mice. Upon Sendai infection, increased the interaction between its E3 ubiquitin ligase TRIM25,...
Abstract The excessive and inappropriate production of reactive oxygen species (ROS) can cause oxidative stress is implicated in the pathogenesis lung cancer. Cyclophilin A (CypA), a member immunophilin family, secreted response to ROS. To determine role CypA injury, we investigated that plays human carcinoma (A549) cells. Here, showed protective effect recombinant (hCypA) on hydrogen peroxide (H2O2)-induced damage A549 cells, which play crucial roles Our results demonstrated hCypA...
The von Hippel-Lindau (VHL) gene is a well-defined tumor suppressor linked to human heredity cancer syndromes. As component of the VHL-elongin B/C E3 ligase complex, pVHL performs its function by targeting proteins for proteasomal degradation. It largely unknown whether functions in antiviral immunity. In this article, we identify that negatively regulates innate immunity, which acts mainly inducing degradation mitochondrial antiviral-signaling protein (MAVS, also known as Cardif, IPS-1, or...
Abstract Membrane-bound fatty acid desaturases (FADs) are of great importance and play multiple roles in plant growth development. In the present study, 39 full-length FAD genes, based on database searches, were identified tetraploid upland cotton ( Gossypium hirsutum L.) phylogenetically clustered into four subfamilies. Genomic localization revealed that 34 genes mapped 22 chromosomes, five positioned scaffold sequences. The G. same subfamily had similar gene structures. structures...
Deregulation of E3 ubiquitin ligases drives the proliferation and metastasis various cancers; however, underlying mechanisms remain unknown. This study aimed to investigate role tripartite motif-containing 22 (TRIM22), a poorly investigated ligase in TRIM family, as tumor suppressor breast cancer. High expression TRIM22 cancer correlated with better prognosis. Functional experiments demonstrated that significantly inhibited invasion cells. Label-free proteomics biochemical analyses revealed...
Brain and neurons are particularly sensitive to reactive oxygen species (ROS). Oxidative damage from ROS results in increased 8-oxoguanine DNA followed by repair through the base excision (BER) pathway. We reported earlier that AP endonuclease 1 (Apex1) not only participates directly BER but also regulates transcription factor Creb1. Here, we investigated how Apex1 affects brain respond effectively oxidative during zebrafish development. Loss of resulted ROS, 8-oxoguanine, abasic sites as...
RIG-I-like receptors (RLRs) play important roles in response to virus infection by regulating host innate immune signaling pathways. Meanwhile, the RLRs pathway is also tightly regulated and achieve homeostasis between antiviral responses survival. Here, we found that zebrafish TRIM25 (zbTRIM25) functioned as a positive regulator of during red spotted grouper nervous necrosis (RGNNV) infection. Post RGNNV infection, zbTRIM25 expression was obviously inhibited ectopic led enhanced related...
The inflammatory response is tightly regulated, but its regulatory principles are still incompletely understood. Cyclophilin A (CypA) has long been considered as a pro-inflammatory factor. Here, we discover how CypA precisely regulates interleukin-1β (IL-1β)-mediated responses. In lipopolysaccharide-treated mice, deficiency initially inhibits and then promotes lung inflammation, which closely related to IL-1β production. Mechanistically, not only facilitates pro-IL-1β processing by...
Long-term or excessive oxidative stress can cause serious damage to fish. Squalene be added feed as an antioxidant improve the body constitution of In this study, activity was detected by 2,2-diphenyl-1-acrylhydrazyl (DPPH) test and fluorescent probe (dichloro-dihydro-fluorescein diacetate). Transgenic Tg (lyz: DsRed2) zebrafish were used evaluate effect squalene on CuSO4-induced inflammatory response. Quantitative real-time reverse transcription polymerase chain reaction examine expression...
In July 2021, a disease with high mortality rate broke out in freshwater cultured hybrid sturgeon Zhengzhou, Henan Province. A dominant strain, H-701, was isolated from diseased fish; physiological changes fish were investigated and molecular identification, biochemical characterization, pathogenicity drug sensitivity tests of H-701 performed. The 16S rRNA gene sequence 99.86% homologous that Vibrio metschnikovii GenBank. 50% lethal dose 3.72 ± 0.929 × 104 CFU/g weight. proportion monocytes,...
Exposure to atrazine (ATR), a widely-used herbicide, is potential harmful human health due its long-term environmental persistence and bioaccumulation. The effects of chronic exposure ATR on renal function in rats were evaluated this research. Female Sprague-Dawley at 4 weeks age treated with different concentrations for 6 months. No significant differences terms functions observed after treatment. In histopathological examination the kidney, Hematoxylin-Eosin staining indicated development...
T-2 toxin (T-2) is a kind of trichothecene produced from Fusarium fungi, which an environmental pollutant that endangers poultry and human health. Heterophil extracellular traps (HETs) are not only form chicken immune defense against pathogen infection but also involved in pathophysiological mechanisms several diseases. However, the immunotoxicity on HET formation vitro has yet been reported. In this study, heterophils were exposed to at doses 20, 40, 80 ng/mL for 90 min. Observation...